2GCP
Crystal structure of the human RhoC-GSP complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0000281 | biological_process | mitotic cytokinesis |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005634 | cellular_component | nucleus |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007015 | biological_process | actin filament organization |
| A | 0007165 | biological_process | signal transduction |
| A | 0007264 | biological_process | small GTPase-mediated signal transduction |
| A | 0016020 | cellular_component | membrane |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030335 | biological_process | positive regulation of cell migration |
| A | 0031334 | biological_process | positive regulation of protein-containing complex assembly |
| A | 0032154 | cellular_component | cleavage furrow |
| A | 0032420 | cellular_component | stereocilium |
| A | 0032956 | biological_process | regulation of actin cytoskeleton organization |
| A | 0043123 | biological_process | positive regulation of canonical NF-kappaB signal transduction |
| A | 0043297 | biological_process | apical junction assembly |
| A | 0044319 | biological_process | wound healing, spreading of cells |
| A | 0051496 | biological_process | positive regulation of stress fiber assembly |
| A | 0060193 | biological_process | positive regulation of lipase activity |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1902766 | biological_process | skeletal muscle satellite cell migration |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 2001 |
| Chain | Residue |
| A | THR19 |
| A | THR37 |
| A | GSP1001 |
| A | HOH3025 |
| A | HOH3036 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 2002 |
| Chain | Residue |
| A | HOH3091 |
| A | HIS105 |
| A | ARG122 |
| A | HOH3089 |
| A | HOH3090 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MG A 2003 |
| Chain | Residue |
| A | ARG145 |
| A | TYR156 |
| site_id | AC4 |
| Number of Residues | 28 |
| Details | BINDING SITE FOR RESIDUE GSP A 1001 |
| Chain | Residue |
| A | GLY14 |
| A | ALA15 |
| A | CYS16 |
| A | GLY17 |
| A | LYS18 |
| A | THR19 |
| A | CYS20 |
| A | PHE30 |
| A | TYR34 |
| A | THR37 |
| A | GLY62 |
| A | LYS118 |
| A | ASP120 |
| A | PHE154 |
| A | SER160 |
| A | ALA161 |
| A | LYS162 |
| A | MG2001 |
| A | EDO3002 |
| A | HOH3015 |
| A | HOH3022 |
| A | HOH3025 |
| A | HOH3036 |
| A | HOH3077 |
| A | HOH3099 |
| A | HOH3100 |
| A | HOH3103 |
| A | HOH3104 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 3001 |
| Chain | Residue |
| A | ASP13 |
| A | GLY14 |
| A | ASP49 |
| A | SER88 |
| A | ASP90 |
| A | SER91 |
| site_id | AC6 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE EDO A 3002 |
| Chain | Residue |
| A | THR19 |
| A | CYS20 |
| A | VAL33 |
| A | TYR34 |
| A | VAL35 |
| A | GSP1001 |
| A | HOH3025 |
| A | HOH3083 |
| A | HOH3103 |
| A | HOH3124 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | GLY12 | |
| A | ASP59 | |
| A | ASN117 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: ADP-ribosylasparagine; by botulinum toxin => ECO:0000250 |
| Chain | Residue | Details |
| A | ASN41 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | CARBOHYD: O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704 |
| Chain | Residue | Details |
| A | TYR34 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | CARBOHYD: (Microbial infection) O-linked (Glc) threonine; by C.difficile toxins TcdA and TcdB => ECO:0000269|PubMed:24905543 |
| Chain | Residue | Details |
| A | THR37 |
