2FP4
Crystal structure of pig GTP-specific succinyl-CoA synthetase in complex with GTP
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0003824 | molecular_function | catalytic activity |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004775 | molecular_function | succinate-CoA ligase (ADP-forming) activity |
| B | 0004776 | molecular_function | succinate-CoA ligase (GDP-forming) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005525 | molecular_function | GTP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0006099 | biological_process | tricarboxylic acid cycle |
| B | 0006104 | biological_process | succinyl-CoA metabolic process |
| B | 0016874 | molecular_function | ligase activity |
| B | 0042709 | cellular_component | succinate-CoA ligase complex |
| B | 0046872 | molecular_function | metal ion binding |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE K B 401 |
| 鎖名 | 残基 |
| B | ASN206 |
| B | ASP220 |
| B | GTP403 |
| B | HOH488 |
| site_id | AC2 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE MG B 402 |
| 鎖名 | 残基 |
| B | SER165 |
| B | GTP404 |
| B | HOH499 |
| site_id | AC3 |
| 残基数 | 19 |
| 詳細 | BINDING SITE FOR RESIDUE GTP B 403 |
| 鎖名 | 残基 |
| B | GLY52 |
| B | GLY53 |
| B | ARG54 |
| B | GLY55 |
| B | VAL67 |
| B | LEU69 |
| B | ALA108 |
| B | LEU109 |
| B | GLU114 |
| B | PHE219 |
| B | ASP220 |
| B | LYS222 |
| B | K401 |
| B | HOH487 |
| B | HOH488 |
| B | HOH489 |
| B | HOH511 |
| B | GLN20 |
| B | VAL44 |
| site_id | AC4 |
| 残基数 | 12 |
| 詳細 | BINDING SITE FOR RESIDUE GTP B 404 |
| 鎖名 | 残基 |
| A | LYS50 |
| B | GLY55 |
| B | LYS56 |
| B | LYS64 |
| B | LYS163 |
| B | ASP164 |
| B | SER165 |
| B | GLN168 |
| B | ARG169 |
| B | GLU172 |
| B | MG402 |
| B | HOH474 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
| site_id | PS00399 |
| 残基数 | 14 |
| 詳細 | SUCCINYL_COA_LIG_2 ATP-citrate lyase / succinyl-CoA ligases family active site. GltAppgr...RMGHAG |
| 鎖名 | 残基 | 詳細 |
| A | GLY248-GLY261 |
| site_id | PS01216 |
| 残基数 | 30 |
| 詳細 | SUCCINYL_COA_LIG_1 ATP-citrate lyase / succinyl-CoA ligases family signature 1. SRSGTLTyEavhqttqvglGqslcVGIGGD |
| 鎖名 | 残基 | 詳細 |
| A | SER160-ASP189 |
| site_id | PS01217 |
| 残基数 | 26 |
| 詳細 | SUCCINYL_COA_LIG_3 ATP-citrate lyase / succinyl-CoA ligases family signature 3. GnIacFvNGAGLAmatcDiIflngGK |
| 鎖名 | 残基 | 詳細 |
| B | GLY264-LYS289 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 1 |
| 詳細 | ACT_SITE: Tele-phosphohistidine intermediate => ECO:0000255|HAMAP-Rule:MF_03222, ECO:0000269|PubMed:10873456, ECO:0000269|PubMed:16481318 |
| 鎖名 | 残基 | 詳細 |
| A | NEP259 | |
| B | GLY53 | |
| B | LEU109 |
| site_id | SWS_FT_FI2 |
| 残基数 | 3 |
| 詳細 | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03222, ECO:0000269|PubMed:26249701 |
| 鎖名 | 残基 | 詳細 |
| A | THR24 | |
| A | LYS50 | |
| A | ILE103 |
| site_id | SWS_FT_FI3 |
| 残基数 | 1 |
| 詳細 | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03222, ECO:0000269|PubMed:27487822 |
| 鎖名 | 残基 | 詳細 |
| A | TYR167 | |
| B | GLY328 |
| site_id | SWS_FT_FI4 |
| 残基数 | 1 |
| 詳細 | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P53597 |
| 鎖名 | 残基 | 詳細 |
| A | LYS14 | |
| B | ASP110 |
| site_id | SWS_FT_FI5 |
| 残基数 | 2 |
| 詳細 | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q9WUM5 |
| 鎖名 | 残基 | 詳細 |
| A | LYS17 | |
| A | LYS26 | |
| B | LYS102 | |
| B | LYS163 | |
| B | LYS234 | |
| B | LYS310 | |
| B | LYS349 | |
| B | LYS386 |
| site_id | SWS_FT_FI6 |
| 残基数 | 1 |
| 詳細 | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q9WUM5 |
| 鎖名 | 残基 | 詳細 |
| A | LYS65 | |
| B | LYS301 |
| site_id | SWS_FT_FI7 |
| 残基数 | 1 |
| 詳細 | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q9WUM5 |
| 鎖名 | 残基 | 詳細 |
| A | LYS298 |
| site_id | SWS_FT_FI8 |
| 残基数 | 2 |
| 詳細 | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q96I99 |
| 鎖名 | 残基 | 詳細 |
| B | LYS190 | |
| B | LYS254 |
