2F7Z
Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine
GO(遺伝子オントロジー)由来の情報
鎖名 | GO(遺伝子オントロジー)id | 名前空間 | 内容 |
E | 0000166 | molecular_function | nucleotide binding |
E | 0001669 | cellular_component | acrosomal vesicle |
E | 0001707 | biological_process | mesoderm formation |
E | 0004672 | molecular_function | protein kinase activity |
E | 0004674 | molecular_function | protein serine/threonine kinase activity |
E | 0004679 | molecular_function | AMP-activated protein kinase activity |
E | 0004691 | molecular_function | cAMP-dependent protein kinase activity |
E | 0005515 | molecular_function | protein binding |
E | 0005524 | molecular_function | ATP binding |
E | 0005634 | cellular_component | nucleus |
E | 0005737 | cellular_component | cytoplasm |
E | 0005739 | cellular_component | mitochondrion |
E | 0005829 | cellular_component | cytosol |
E | 0005886 | cellular_component | plasma membrane |
E | 0005952 | cellular_component | cAMP-dependent protein kinase complex |
E | 0006468 | biological_process | protein phosphorylation |
E | 0010737 | biological_process | protein kinase A signaling |
E | 0016020 | cellular_component | membrane |
E | 0016301 | molecular_function | kinase activity |
E | 0016310 | biological_process | phosphorylation |
E | 0016740 | molecular_function | transferase activity |
E | 0018105 | biological_process | peptidyl-serine phosphorylation |
E | 0019904 | molecular_function | protein domain specific binding |
E | 0031594 | cellular_component | neuromuscular junction |
E | 0034237 | molecular_function | protein kinase A regulatory subunit binding |
E | 0034605 | biological_process | cellular response to heat |
E | 0036126 | cellular_component | sperm flagellum |
E | 0048471 | cellular_component | perinuclear region of cytoplasm |
E | 0106310 | molecular_function | protein serine kinase activity |
E | 1904262 | biological_process | negative regulation of TORC1 signaling |
I | 0004862 | molecular_function | cAMP-dependent protein kinase inhibitor activity |
I | 0006469 | biological_process | negative regulation of protein kinase activity |
PDBデータベースに由来する情報
site_id | AC1 |
残基数 | 14 |
詳細 | BINDING SITE FOR RESIDUE 6EA E 1000 |
鎖名 | 残基 |
E | GLY52 |
E | ASN171 |
E | LEU173 |
E | THR183 |
E | ASP184 |
E | PHE327 |
E | SER53 |
E | GLY55 |
E | ALA70 |
E | LYS72 |
E | GLU121 |
E | TYR122 |
E | VAL123 |
E | LYS168 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
SwissProt/UniProtに記載されている蛋白質分子機能情報
site_id | SWS_FT_FI1 |
残基数 | 3 |
詳細 | SITE: Important for inhibition |
鎖名 | 残基 | 詳細 |
I | ARG15 | |
I | ARG18 | |
I | ARG19 |
site_id | SWS_FT_FI2 |
残基数 | 2 |
詳細 | BINDING: |
鎖名 | 残基 | 詳細 |
E | GLY50 | |
E | ILE73 |
site_id | SWS_FT_FI3 |
残基数 | 2 |
詳細 | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 |
鎖名 | 残基 | 詳細 |
E | PRO169 | |
E | TYR122 |
site_id | SWS_FT_FI4 |
残基数 | 1 |
詳細 | MOD_RES: Deamidated asparagine; partial => ECO:0000269|PubMed:10684253, ECO:0000269|PubMed:11152138, ECO:0000269|PubMed:9521123 |
鎖名 | 残基 | 詳細 |
E | ALA3 |
site_id | SWS_FT_FI5 |
残基数 | 1 |
詳細 | MOD_RES: Phosphoserine; by autocatalysis => ECO:0000250|UniProtKB:P05132 |
鎖名 | 残基 | 詳細 |
E | GLU11 |
site_id | SWS_FT_FI6 |
残基数 | 2 |
詳細 | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P17612 |
鎖名 | 残基 | 詳細 |
E | TRP196 | |
E | LEU49 |
site_id | SWS_FT_FI7 |
残基数 | 1 |
詳細 | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P05132 |
鎖名 | 残基 | 詳細 |
E | GLU140 |
site_id | SWS_FT_FI8 |
残基数 | 1 |
詳細 | MOD_RES: Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:6262777 |
鎖名 | 残基 | 詳細 |
E | LEU198 |
site_id | SWS_FT_FI9 |
残基数 | 1 |
詳細 | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P05132 |
鎖名 | 残基 | 詳細 |
E | GLU331 |
site_id | SWS_FT_FI10 |
残基数 | 1 |
詳細 | MOD_RES: Phosphoserine => ECO:0000269|PubMed:6262777 |
鎖名 | 残基 | 詳細 |
E | ILE339 |
site_id | SWS_FT_FI11 |
残基数 | 1 |
詳細 | LIPID: N-myristoyl glycine => ECO:0000269|PubMed:6262777 |
鎖名 | 残基 | 詳細 |
E | ASN2 |
CSAにおける酵素触媒機能の情報
site_id | MCSA1 |
残基数 | 5 |
詳細 | M-CSA 757 |
鎖名 | 残基 | 詳細 |
E | LEU167 | activator, proton acceptor, proton donor |
E | PRO169 | electrostatic stabiliser, polar interaction |
E | LEU172 | metal ligand |
E | PHE185 | metal ligand |
E | PRO202 | electrostatic stabiliser, polar interaction |