Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

2C6O

Crystal structure of the human CDK2 complexed with the triazolopyrimidine inhibitor

Functional Information from GO Data
ChainGOidnamespacecontents
A0000082biological_processG1/S transition of mitotic cell cycle
A0000086biological_processG2/M transition of mitotic cell cycle
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000166molecular_functionnucleotide binding
A0000287molecular_functionmagnesium ion binding
A0000307cellular_componentcyclin-dependent protein kinase holoenzyme complex
A0000781cellular_componentchromosome, telomeric region
A0000793cellular_componentcondensed chromosome
A0000805cellular_componentX chromosome
A0000806cellular_componentY chromosome
A0001673cellular_componentmale germ cell nucleus
A0004672molecular_functionprotein kinase activity
A0004674molecular_functionprotein serine/threonine kinase activity
A0004693molecular_functioncyclin-dependent protein serine/threonine kinase activity
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005654cellular_componentnucleoplasm
A0005667cellular_componenttranscription regulator complex
A0005737cellular_componentcytoplasm
A0005768cellular_componentendosome
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006260biological_processDNA replication
A0006281biological_processDNA repair
A0006338biological_processchromatin remodeling
A0006351biological_processDNA-templated transcription
A0006468biological_processprotein phosphorylation
A0006813biological_processpotassium ion transport
A0006974biological_processDNA damage response
A0007049biological_processcell cycle
A0007099biological_processcentriole replication
A0007165biological_processsignal transduction
A0007265biological_processRas protein signal transduction
A0007346biological_processregulation of mitotic cell cycle
A0008284biological_processpositive regulation of cell population proliferation
A0010033biological_processresponse to organic substance
A0010389biological_processregulation of G2/M transition of mitotic cell cycle
A0010468biological_processregulation of gene expression
A0015030cellular_componentCajal body
A0016301molecular_functionkinase activity
A0016310biological_processphosphorylation
A0016740molecular_functiontransferase activity
A0018105biological_processpeptidyl-serine phosphorylation
A0019904molecular_functionprotein domain specific binding
A0030332molecular_functioncyclin binding
A0031453biological_processpositive regulation of heterochromatin formation
A0031571biological_processmitotic G1 DNA damage checkpoint signaling
A0032298biological_processpositive regulation of DNA-templated DNA replication initiation
A0035173molecular_functionhistone kinase activity
A0043687biological_processpost-translational protein modification
A0045740biological_processpositive regulation of DNA replication
A0045893biological_processpositive regulation of DNA-templated transcription
A0046872molecular_functionmetal ion binding
A0051298biological_processcentrosome duplication
A0051301biological_processcell division
A0051321biological_processmeiotic cell cycle
A0071732biological_processcellular response to nitric oxide
A0090398biological_processcellular senescence
A0097123cellular_componentcyclin A1-CDK2 complex
A0097124cellular_componentcyclin A2-CDK2 complex
A0097134cellular_componentcyclin E1-CDK2 complex
A0097135cellular_componentcyclin E2-CDK2 complex
A0097472molecular_functioncyclin-dependent protein kinase activity
A0106310molecular_functionprotein serine kinase activity
A1905784biological_processregulation of anaphase-promoting complex-dependent catabolic process
Functional Information from PDB Data
site_idAC1
Number of Residues17
DetailsBINDING SITE FOR RESIDUE 4SP A1297
ChainResidue
AILE10
AHIS84
AGLN85
AASP86
ALYS89
AGLN131
ALEU134
AHOH2011
AHOH2060
AGLY13
AVAL18
AALA31
ALYS33
APHE80
AGLU81
APHE82
ALEU83

Functional Information from PROSITE/UniProt
site_idPS00107
Number of Residues24
DetailsPROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGEGTYGVVYkArnkltgev..........VALK
ChainResidueDetails
AILE10-LYS33

site_idPS00108
Number of Residues13
DetailsPROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. VlHrDLKpqNLLI
ChainResidueDetails
AVAL123-ILE135

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsACT_SITE: Proton acceptor
ChainResidueDetails
AASP127

site_idSWS_FT_FI2
Number of Residues5
DetailsBINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:21565702
ChainResidueDetails
AILE10
ALYS33
AGLU81
AASP86
ALYS129

site_idSWS_FT_FI3
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:21565702
ChainResidueDetails
AASN132
AASP145

site_idSWS_FT_FI4
Number of Residues3
DetailsSITE: CDK7 binding
ChainResidueDetails
ALYS9
ALYS88
ALEU166

site_idSWS_FT_FI5
Number of Residues1
DetailsMOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378
ChainResidueDetails
AMET1

site_idSWS_FT_FI6
Number of Residues1
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS6

site_idSWS_FT_FI7
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507
ChainResidueDetails
ATHR14

site_idSWS_FT_FI8
Number of Residues1
DetailsMOD_RES: Phosphotyrosine; by WEE1 => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:17095507, ECO:0007744|PubMed:19690332
ChainResidueDetails
ATYR15

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:19369195
ChainResidueDetails
ATYR19

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphothreonine; by CAK and CCRK => ECO:0000269|PubMed:1396589, ECO:0000269|PubMed:14597612, ECO:0000269|PubMed:16325401, ECO:0000269|PubMed:17095507, ECO:0000269|PubMed:17570665, ECO:0000269|PubMed:20147522, ECO:0000269|PubMed:20360007, ECO:0000269|PubMed:21565702, ECO:0000305|PubMed:28666995
ChainResidueDetails
ATHR160

217705

數據於2024-03-27公開中

PDB statisticsPDBj update infoContact PDBjnumon