Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2BUF

Arginine Feed-Back Inhibitable Acetylglutamate Kinase

Replaces: 1UVD

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
A	0003991	molecular_function	acetylglutamate kinase activity
A	0004042	molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0006526	biological_process	arginine biosynthetic process
A	0006536	biological_process	glutamate metabolic process
A	0008652	biological_process	amino acid biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0042450	biological_process	arginine biosynthetic process via ornithine
B	0000166	molecular_function	nucleotide binding
B	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
B	0003991	molecular_function	acetylglutamate kinase activity
B	0004042	molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0006526	biological_process	arginine biosynthetic process
B	0006536	biological_process	glutamate metabolic process
B	0008652	biological_process	amino acid biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016740	molecular_function	transferase activity
B	0042450	biological_process	arginine biosynthetic process via ornithine
C	0000166	molecular_function	nucleotide binding
C	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
C	0003991	molecular_function	acetylglutamate kinase activity
C	0004042	molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0006526	biological_process	arginine biosynthetic process
C	0006536	biological_process	glutamate metabolic process
C	0008652	biological_process	amino acid biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016740	molecular_function	transferase activity
C	0042450	biological_process	arginine biosynthetic process via ornithine
D	0000166	molecular_function	nucleotide binding
D	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
D	0003991	molecular_function	acetylglutamate kinase activity
D	0004042	molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0006526	biological_process	arginine biosynthetic process
D	0006536	biological_process	glutamate metabolic process
D	0008652	biological_process	amino acid biosynthetic process
D	0016301	molecular_function	kinase activity
D	0016310	biological_process	phosphorylation
D	0016740	molecular_function	transferase activity
D	0042450	biological_process	arginine biosynthetic process via ornithine
E	0000166	molecular_function	nucleotide binding
E	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
E	0003991	molecular_function	acetylglutamate kinase activity
E	0004042	molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0006526	biological_process	arginine biosynthetic process
E	0006536	biological_process	glutamate metabolic process
E	0008652	biological_process	amino acid biosynthetic process
E	0016301	molecular_function	kinase activity
E	0016310	biological_process	phosphorylation
E	0016740	molecular_function	transferase activity
E	0042450	biological_process	arginine biosynthetic process via ornithine
F	0000166	molecular_function	nucleotide binding
F	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
F	0003991	molecular_function	acetylglutamate kinase activity
F	0004042	molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0006526	biological_process	arginine biosynthetic process
F	0006536	biological_process	glutamate metabolic process
F	0008652	biological_process	amino acid biosynthetic process
F	0016301	molecular_function	kinase activity
F	0016310	biological_process	phosphorylation
F	0016740	molecular_function	transferase activity
F	0042450	biological_process	arginine biosynthetic process via ornithine
G	0000166	molecular_function	nucleotide binding
G	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
G	0003991	molecular_function	acetylglutamate kinase activity
G	0004042	molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity
G	0005524	molecular_function	ATP binding
G	0005737	cellular_component	cytoplasm
G	0006526	biological_process	arginine biosynthetic process
G	0006536	biological_process	glutamate metabolic process
G	0008652	biological_process	amino acid biosynthetic process
G	0016301	molecular_function	kinase activity
G	0016310	biological_process	phosphorylation
G	0016740	molecular_function	transferase activity
G	0042450	biological_process	arginine biosynthetic process via ornithine
H	0000166	molecular_function	nucleotide binding
H	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
H	0003991	molecular_function	acetylglutamate kinase activity
H	0004042	molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity
H	0005524	molecular_function	ATP binding
H	0005737	cellular_component	cytoplasm
H	0006526	biological_process	arginine biosynthetic process
H	0006536	biological_process	glutamate metabolic process
H	0008652	biological_process	amino acid biosynthetic process
H	0016301	molecular_function	kinase activity
H	0016310	biological_process	phosphorylation
H	0016740	molecular_function	transferase activity
H	0042450	biological_process	arginine biosynthetic process via ornithine
I	0000166	molecular_function	nucleotide binding
I	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
I	0003991	molecular_function	acetylglutamate kinase activity
I	0004042	molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity
I	0005524	molecular_function	ATP binding
I	0005737	cellular_component	cytoplasm
I	0006526	biological_process	arginine biosynthetic process
I	0006536	biological_process	glutamate metabolic process
I	0008652	biological_process	amino acid biosynthetic process
I	0016301	molecular_function	kinase activity
I	0016310	biological_process	phosphorylation
I	0016740	molecular_function	transferase activity
I	0042450	biological_process	arginine biosynthetic process via ornithine
J	0000166	molecular_function	nucleotide binding
J	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
J	0003991	molecular_function	acetylglutamate kinase activity
J	0004042	molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity
J	0005524	molecular_function	ATP binding
J	0005737	cellular_component	cytoplasm
J	0006526	biological_process	arginine biosynthetic process
J	0006536	biological_process	glutamate metabolic process
J	0008652	biological_process	amino acid biosynthetic process
J	0016301	molecular_function	kinase activity
J	0016310	biological_process	phosphorylation
J	0016740	molecular_function	transferase activity
J	0042450	biological_process	arginine biosynthetic process via ornithine
K	0000166	molecular_function	nucleotide binding
K	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
K	0003991	molecular_function	acetylglutamate kinase activity
K	0004042	molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity
K	0005524	molecular_function	ATP binding
K	0005737	cellular_component	cytoplasm
K	0006526	biological_process	arginine biosynthetic process
K	0006536	biological_process	glutamate metabolic process
K	0008652	biological_process	amino acid biosynthetic process
K	0016301	molecular_function	kinase activity
K	0016310	biological_process	phosphorylation
K	0016740	molecular_function	transferase activity
K	0042450	biological_process	arginine biosynthetic process via ornithine
L	0000166	molecular_function	nucleotide binding
L	0003942	molecular_function	N-acetyl-gamma-glutamyl-phosphate reductase activity
L	0003991	molecular_function	acetylglutamate kinase activity
L	0004042	molecular_function	acetyl-CoA:L-glutamate N-acetyltransferase activity
L	0005524	molecular_function	ATP binding
L	0005737	cellular_component	cytoplasm
L	0006526	biological_process	arginine biosynthetic process
L	0006536	biological_process	glutamate metabolic process
L	0008652	biological_process	amino acid biosynthetic process
L	0016301	molecular_function	kinase activity
L	0016310	biological_process	phosphorylation
L	0016740	molecular_function	transferase activity
L	0042450	biological_process	arginine biosynthetic process via ornithine

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG B1301

Chain	Residue
B	ASN197
B	ADP1300

site_id	AC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG C1301

Chain	Residue
C	ADP1300

site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG D1301

Chain	Residue
D	ADP1300

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE MG E1300

Chain	Residue
E	ASN197
E	ADP1299
E	NLG1301

site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE MG G1300

Chain	Residue
G	ADP1299

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G1302

Chain	Residue
G	TYR249
C	ARG5

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG H1298

Chain	Residue
H	ASN37
H	ADP1297

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG I1299

Chain	Residue
I	ASP199
I	ADP1298

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE MG L1301

Chain	Residue
L	ASN197
L	ADP1300

site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL L1303

Chain	Residue
L	MET224

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE NLG A1302

Chain	Residue
A	GLY67
A	GLY68
A	GLY88
A	MET89
A	ARG90
A	ASN195
A	ALA198

site_id	BC3
Number of Residues	16
Details	BINDING SITE FOR RESIDUE ADP B1300

Chain	Residue
B	LYS33
B	GLY36
B	ASN37
B	ASP199
B	THR218
B	ASN219
B	ILE220
B	GLY222
B	LEU223
B	MET224
B	THR247
B	TYR249
B	GLY251
B	MET252
B	LYS255
B	MG1301

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NLG B1302

Chain	Residue
B	GLY67
B	GLY68
B	MET89
B	ARG90
B	VAL159
B	ASN195
B	ILE196
B	ASN197
B	ALA198

site_id	BC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP C1300

Chain	Residue
C	ASN37
C	THR218
C	ASN219
C	LEU223
C	MET224
C	THR247
C	TYR249
C	GLY251
C	MET252
C	LYS255
C	MG1301

site_id	BC6
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP D1300

Chain	Residue
A	LYS77
D	THR218
D	ASN219
D	ILE220
D	GLY222
D	MET224
D	THR247
D	TYR249
D	GLY251
D	MET252
D	LYS255
D	MG1301

site_id	BC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NLG D1302

Chain	Residue
D	GLY67
D	GLY68
D	ILE72
D	ARG90
D	VAL159
D	ASN195
D	ASN197
D	ALA198

site_id	BC8
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP E1299

Chain	Residue
E	LYS33
E	GLY36
E	ASN37
E	THR218
E	ASN219
E	ILE220
E	LEU223
E	MET224
E	THR247
E	TYR249
E	GLY251
E	MET252
E	LYS255
E	MG1300

site_id	BC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NLG E1301

Chain	Residue
E	ASN195
E	ASN197
E	ALA198
E	MG1300
E	GLY67
E	GLY68
E	GLY88
E	MET89
E	ARG90

site_id	CC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP F1299

Chain	Residue
F	ASN37
F	THR218
F	ASN219
F	ILE220
F	GLY222
F	MET224
F	THR247
F	ILE248
F	TYR249
F	GLY251
F	MET252
F	LYS255
K	MET39

site_id	CC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NLG F1300

Chain	Residue
F	GLY67
F	GLY68
F	MET89
F	ARG90
F	VAL159
F	ASN195
F	ILE196
F	ASN197
F	ALA198

site_id	CC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE ADP G1299

Chain	Residue
G	THR218
G	ASN219
G	GLY222
G	LEU223
G	MET224
G	THR247
G	TYR249
G	GLY251
G	MET252
G	LYS255
G	MG1300

site_id	CC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NLG G1301

Chain	Residue
G	GLY67
G	ILE72
G	MET89
G	ARG90
G	ASN195
G	ALA198

site_id	CC5
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP H1297

Chain	Residue
H	ASN37
H	ASP199
H	THR218
H	ASN219
H	ILE220
H	GLY222
H	LEU223
H	MET224
H	THR247
H	TYR249
H	GLY251
H	MET252
H	LYS255
H	MG1298

site_id	CC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE NLG H1299

Chain	Residue
H	GLY67
H	GLY69
H	ILE72
H	ARG90
H	PRO184
H	ASN195
H	ILE196
H	ASN197
H	ALA198

site_id	CC7
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ADP I1298

Chain	Residue
I	LYS33
I	ASN37
I	THR218
I	GLY222
I	LEU223
I	MET224
I	THR247
I	ILE248
I	TYR249
I	GLY251
I	MET252
I	LYS255
I	MG1299

site_id	CC8
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NLG I1300

Chain	Residue
I	ILE72
I	MET89
I	ARG90
I	VAL159
I	ASN195
I	ILE196
I	ASN197
I	ALA198

site_id	CC9
Number of Residues	12
Details	BINDING SITE FOR RESIDUE ADP J1298

Chain	Residue
J	ASN37
J	THR218
J	ASN219
J	ILE220
J	LEU223
J	MET224
J	THR247
J	ILE248
J	TYR249
J	GLY251
J	MET252
J	LYS255

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NLG K1298

Chain	Residue
K	ARG90
K	ASN195
K	ILE196
K	ASN197
K	ALA198

site_id	DC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE ADP L1300

Chain	Residue
E	LYS226
L	THR218
L	ASN219
L	ILE220
L	GLY222
L	LEU223
L	MET224
L	THR247
L	ILE248
L	TYR249
L	GLY251
L	MET252
L	LYS255
L	MG1301

site_id	DC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE NLG L1302

Chain	Residue
L	GLY67
L	GLY68
L	GLY88
L	MET89
L	ARG90
L	ASN195
L	ASN197
L	ALA198

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00082

Chain	Residue	Details
A	GLY69
B	GLY69
C	GLY69
D	GLY69
E	GLY69
F	GLY69
G	GLY69
H	GLY69
I	GLY69
J	GLY69
K	GLY69
L	GLY69

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00082, ECO:0000269\|PubMed:16376937

Chain	Residue	Details
A	VAL91
A	ILE196
B	VAL91
B	ILE196
C	VAL91
C	ILE196
D	VAL91
D	ILE196
E	VAL91
E	ILE196
F	VAL91
F	ILE196
G	VAL91
G	ILE196
H	VAL91
H	ILE196
I	VAL91
I	ILE196
J	VAL91
J	ILE196
K	VAL91
K	ILE196
L	VAL91
L	ILE196

site_id	SWS_FT_FI3
Number of Residues	24
Details	SITE: Transition state stabilizer => ECO:0000255\|HAMAP-Rule:MF_00082

Chain	Residue	Details
A	TYR34
A	ILE256
B	TYR34
B	ILE256
C	TYR34
C	ILE256
D	TYR34
D	ILE256
E	TYR34
E	ILE256
F	TYR34
F	ILE256
G	TYR34
G	ILE256
H	TYR34
H	ILE256
I	TYR34
I	ILE256
J	TYR34
J	ILE256
K	TYR34
K	ILE256
L	TYR34
L	ILE256

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)