Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

2AW5

Crystal structure of a human malic enzyme

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0004470	molecular_function	malic enzyme activity
A	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005829	cellular_component	cytosol
A	0005975	biological_process	carbohydrate metabolic process
A	0006090	biological_process	pyruvate metabolic process
A	0006108	biological_process	malate metabolic process
A	0006734	biological_process	NADH metabolic process
A	0006739	biological_process	NADP metabolic process
A	0008948	molecular_function	oxaloacetate decarboxylase activity
A	0009055	molecular_function	electron transfer activity
A	0009165	biological_process	nucleotide biosynthetic process
A	0009725	biological_process	response to hormone
A	0009743	biological_process	response to carbohydrate
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0030145	molecular_function	manganese ion binding
A	0042802	molecular_function	identical protein binding
A	0043531	molecular_function	ADP binding
A	0046872	molecular_function	metal ion binding
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
A	0051289	biological_process	protein homotetramerization
A	1902031	biological_process	regulation of NADP metabolic process
B	0000287	molecular_function	magnesium ion binding
B	0004470	molecular_function	malic enzyme activity
B	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005829	cellular_component	cytosol
B	0005975	biological_process	carbohydrate metabolic process
B	0006090	biological_process	pyruvate metabolic process
B	0006108	biological_process	malate metabolic process
B	0006734	biological_process	NADH metabolic process
B	0006739	biological_process	NADP metabolic process
B	0008948	molecular_function	oxaloacetate decarboxylase activity
B	0009055	molecular_function	electron transfer activity
B	0009165	biological_process	nucleotide biosynthetic process
B	0009725	biological_process	response to hormone
B	0009743	biological_process	response to carbohydrate
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0030145	molecular_function	manganese ion binding
B	0042802	molecular_function	identical protein binding
B	0043531	molecular_function	ADP binding
B	0046872	molecular_function	metal ion binding
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
B	0051289	biological_process	protein homotetramerization
B	1902031	biological_process	regulation of NADP metabolic process
C	0000287	molecular_function	magnesium ion binding
C	0004470	molecular_function	malic enzyme activity
C	0004473	molecular_function	malate dehydrogenase (decarboxylating) (NADP+) activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005739	cellular_component	mitochondrion
C	0005829	cellular_component	cytosol
C	0005975	biological_process	carbohydrate metabolic process
C	0006090	biological_process	pyruvate metabolic process
C	0006108	biological_process	malate metabolic process
C	0006734	biological_process	NADH metabolic process
C	0006739	biological_process	NADP metabolic process
C	0008948	molecular_function	oxaloacetate decarboxylase activity
C	0009055	molecular_function	electron transfer activity
C	0009165	biological_process	nucleotide biosynthetic process
C	0009725	biological_process	response to hormone
C	0009743	biological_process	response to carbohydrate
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0030145	molecular_function	manganese ion binding
C	0042802	molecular_function	identical protein binding
C	0043531	molecular_function	ADP binding
C	0046872	molecular_function	metal ion binding
C	0050661	molecular_function	NADP binding
C	0051287	molecular_function	NAD binding
C	0051289	biological_process	protein homotetramerization
C	1902031	biological_process	regulation of NADP metabolic process

Functional Information from PROSITE/UniProt

site_id	PS00331
Number of Residues	17
Details	MALIC_ENZYMES Malic enzymes signature. FnDDiqGTAsVaVAGLL

Chain	Residue	Details
A	PHE266-LEU282

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Proton donor => ECO:0000250\|UniProtKB:P23368

Chain	Residue	Details
A	TYR102
B	TYR102
C	TYR102

site_id	SWS_FT_FI2
Number of Residues	3
Details	ACT_SITE: Proton acceptor => ECO:0000250\|UniProtKB:P23368

Chain	Residue	Details
A	LYS173
B	LYS173
C	LYS173

site_id	SWS_FT_FI3
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	ASN408
B	ARG155
B	ASP269
B	GLY301
B	ASN408
C	ARG155
C	ASP269
C	GLY301
C	ASN408
A	ARG155
A	ASP269
A	GLY301

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P23368

Chain	Residue	Details
A	GLU245
A	ASP246
B	GLU245
B	ASP246
C	GLU245
C	ASP246

site_id	SWS_FT_FI5
Number of Residues	3
Details	SITE: Important for activity => ECO:0000250

Chain	Residue	Details
A	ASP269
B	ASP269
C	ASP269

site_id	SWS_FT_FI6
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P06801

Chain	Residue	Details
A	SER336
B	SER336
C	SER336

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)