1U1G

Structure of E. coli uridine phosphorylase complexed to 5-(m-(benzyloxy)benzyl)barbituric acid (BBBA)

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0003824	molecular_function	catalytic activity
A	0004731	molecular_function	purine-nucleoside phosphorylase activity
A	0004850	molecular_function	uridine phosphorylase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006152	biological_process	purine nucleoside catabolic process
A	0006218	biological_process	uridine catabolic process
A	0006974	biological_process	DNA damage response
A	0009116	biological_process	nucleoside metabolic process
A	0009164	biological_process	nucleoside catabolic process
A	0009166	biological_process	nucleotide catabolic process
A	0016740	molecular_function	transferase activity
A	0016757	molecular_function	glycosyltransferase activity
A	0016763	molecular_function	pentosyltransferase activity
A	0030955	molecular_function	potassium ion binding
A	0032991	cellular_component	protein-containing complex
A	0042802	molecular_function	identical protein binding
A	0044206	biological_process	UMP salvage
B	0003824	molecular_function	catalytic activity
B	0004731	molecular_function	purine-nucleoside phosphorylase activity
B	0004850	molecular_function	uridine phosphorylase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006152	biological_process	purine nucleoside catabolic process
B	0006218	biological_process	uridine catabolic process
B	0006974	biological_process	DNA damage response
B	0009116	biological_process	nucleoside metabolic process
B	0009164	biological_process	nucleoside catabolic process
B	0009166	biological_process	nucleotide catabolic process
B	0016740	molecular_function	transferase activity
B	0016757	molecular_function	glycosyltransferase activity
B	0016763	molecular_function	pentosyltransferase activity
B	0030955	molecular_function	potassium ion binding
B	0032991	cellular_component	protein-containing complex
B	0042802	molecular_function	identical protein binding
B	0044206	biological_process	UMP salvage
C	0003824	molecular_function	catalytic activity
C	0004731	molecular_function	purine-nucleoside phosphorylase activity
C	0004850	molecular_function	uridine phosphorylase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006152	biological_process	purine nucleoside catabolic process
C	0006218	biological_process	uridine catabolic process
C	0006974	biological_process	DNA damage response
C	0009116	biological_process	nucleoside metabolic process
C	0009164	biological_process	nucleoside catabolic process
C	0009166	biological_process	nucleotide catabolic process
C	0016740	molecular_function	transferase activity
C	0016757	molecular_function	glycosyltransferase activity
C	0016763	molecular_function	pentosyltransferase activity
C	0030955	molecular_function	potassium ion binding
C	0032991	cellular_component	protein-containing complex
C	0042802	molecular_function	identical protein binding
C	0044206	biological_process	UMP salvage
D	0003824	molecular_function	catalytic activity
D	0004731	molecular_function	purine-nucleoside phosphorylase activity
D	0004850	molecular_function	uridine phosphorylase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006152	biological_process	purine nucleoside catabolic process
D	0006218	biological_process	uridine catabolic process
D	0006974	biological_process	DNA damage response
D	0009116	biological_process	nucleoside metabolic process
D	0009164	biological_process	nucleoside catabolic process
D	0009166	biological_process	nucleotide catabolic process
D	0016740	molecular_function	transferase activity
D	0016757	molecular_function	glycosyltransferase activity
D	0016763	molecular_function	pentosyltransferase activity
D	0030955	molecular_function	potassium ion binding
D	0032991	cellular_component	protein-containing complex
D	0042802	molecular_function	identical protein binding
D	0044206	biological_process	UMP salvage
E	0003824	molecular_function	catalytic activity
E	0004731	molecular_function	purine-nucleoside phosphorylase activity
E	0004850	molecular_function	uridine phosphorylase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006152	biological_process	purine nucleoside catabolic process
E	0006218	biological_process	uridine catabolic process
E	0006974	biological_process	DNA damage response
E	0009116	biological_process	nucleoside metabolic process
E	0009164	biological_process	nucleoside catabolic process
E	0009166	biological_process	nucleotide catabolic process
E	0016740	molecular_function	transferase activity
E	0016757	molecular_function	glycosyltransferase activity
E	0016763	molecular_function	pentosyltransferase activity
E	0030955	molecular_function	potassium ion binding
E	0032991	cellular_component	protein-containing complex
E	0042802	molecular_function	identical protein binding
E	0044206	biological_process	UMP salvage
F	0003824	molecular_function	catalytic activity
F	0004731	molecular_function	purine-nucleoside phosphorylase activity
F	0004850	molecular_function	uridine phosphorylase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006152	biological_process	purine nucleoside catabolic process
F	0006218	biological_process	uridine catabolic process
F	0006974	biological_process	DNA damage response
F	0009116	biological_process	nucleoside metabolic process
F	0009164	biological_process	nucleoside catabolic process
F	0009166	biological_process	nucleotide catabolic process
F	0016740	molecular_function	transferase activity
F	0016757	molecular_function	glycosyltransferase activity
F	0016763	molecular_function	pentosyltransferase activity
F	0030955	molecular_function	potassium ion binding
F	0032991	cellular_component	protein-containing complex
F	0042802	molecular_function	identical protein binding
F	0044206	biological_process	UMP salvage

PDBデータベースに由来する情報

site_id	AC1
残基数	6
詳細	BINDING SITE FOR RESIDUE K C 1001

鎖名	残基
C	GLU49
C	ILE69
C	SER73
D	GLU49
D	ILE69
D	SER73

site_id	AC2
残基数	6
詳細	BINDING SITE FOR RESIDUE K A 1002

鎖名	残基
B	GLU49
B	ILE69
B	SER73
A	GLU49
A	ILE69
A	SER73

site_id	AC3
残基数	6
詳細	BINDING SITE FOR RESIDUE K E 1003

鎖名	残基
E	GLU49
E	ILE69
E	SER73
F	GLU49
F	ILE69
F	SER73

site_id	AC4
残基数	12
詳細	BINDING SITE FOR RESIDUE BBB A 3300

鎖名	残基
A	THR94
A	THR95
A	GLY96
A	PHE162
A	GLN166
A	ARG168
A	GLU196
A	MET197
A	HOH3305
B	PHE7
B	HIS8
B	ARG48

site_id	AC5
残基数	12
詳細	BINDING SITE FOR RESIDUE BBB B 4300

鎖名	残基
A	PHE7
A	HIS8
A	ARG48
B	THR94
B	PHE162
B	GLN166
B	ARG168
B	TYR195
B	GLU196
B	MET197
B	GLU227
B	HOH4376

site_id	AC6
残基数	14
詳細	BINDING SITE FOR RESIDUE BBB C 5300

鎖名	残基
C	THR94
C	THR95
C	GLY96
C	GLN166
C	ARG168
C	TYR195
C	GLU196
C	MET197
C	MET234
C	HOH5320
C	HOH5392
D	PHE7
D	HIS8
D	ARG48

site_id	AC7
残基数	12
詳細	BINDING SITE FOR RESIDUE BBB D 6300

鎖名	残基
C	PHE7
C	HIS8
D	THR94
D	THR95
D	GLY96
D	GLN166
D	ARG168
D	TYR195
D	GLU196
D	MET197
D	GLU227
D	HOH6321

site_id	AC8
残基数	14
詳細	BINDING SITE FOR RESIDUE BBB E 7300

鎖名	残基
E	THR94
E	THR95
E	GLY96
E	PHE162
E	GLN166
E	ARG168
E	TYR195
E	GLU196
E	MET197
E	VAL221
E	HOH7314
F	PHE7
F	HIS8
F	ARG48

site_id	AC9
残基数	10
詳細	BINDING SITE FOR RESIDUE BBB F 8300

鎖名	残基
E	PHE7
E	HIS8
E	ARG48
F	THR94
F	PHE162
F	GLN166
F	ARG168
F	TYR195
F	GLU196
F	HOH8307

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS01232
残基数	16
詳細	PNP_UDP_1 Purine and other phosphorylases family 1 signature. StGIGgPStSIaveEL

鎖名	残基	詳細
A	SER66-LEU81

CSAにおける酵素触媒機能の情報

site_id	MCSA1
残基数	4
詳細	M-CSA 787

鎖名	残基	詳細
A	LEU9	proton acceptor, proton donor
A	LEU81	electrostatic stabiliser, polar interaction
A	TYR169	proton acceptor, proton donor
A	THR224	electrostatic stabiliser, polar interaction

site_id	MCSA2
残基数	4
詳細	M-CSA 787

鎖名	残基	詳細
B	LEU9	proton acceptor, proton donor
B	LEU81	electrostatic stabiliser, polar interaction
B	TYR169	proton acceptor, proton donor
B	THR224	electrostatic stabiliser, polar interaction

site_id	MCSA3
残基数	4
詳細	M-CSA 787

鎖名	残基	詳細
C	LEU9	proton acceptor, proton donor
C	LEU81	electrostatic stabiliser, polar interaction
C	TYR169	proton acceptor, proton donor
C	THR224	electrostatic stabiliser, polar interaction

site_id	MCSA4
残基数	4
詳細	M-CSA 787

鎖名	残基	詳細
D	LEU9	proton acceptor, proton donor
D	LEU81	electrostatic stabiliser, polar interaction
D	TYR169	proton acceptor, proton donor
D	THR224	electrostatic stabiliser, polar interaction

site_id	MCSA5
残基数	4
詳細	M-CSA 787

鎖名	残基	詳細
E	LEU9	proton acceptor, proton donor
E	LEU81	electrostatic stabiliser, polar interaction
E	TYR169	proton acceptor, proton donor
E	THR224	electrostatic stabiliser, polar interaction

site_id	MCSA6
残基数	4
詳細	M-CSA 787

鎖名	残基	詳細
F	LEU9	proton acceptor, proton donor
F	LEU81	electrostatic stabiliser, polar interaction
F	TYR169	proton acceptor, proton donor
F	THR224	electrostatic stabiliser, polar interaction

		Sequence (fasta)
		PDBx/mmCIF
		PDBML (ヘッダのみ (no-atom))
		PDB形式 (全ての情報)
		検証レポート (PDF)
		EDMap 2fo-fc (MTZ)