1QU2

INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0000166	molecular_function	nucleotide binding
A	0002161	molecular_function	aminoacyl-tRNA editing activity
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004822	molecular_function	isoleucine-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006428	biological_process	isoleucyl-tRNA aminoacylation
A	0008270	molecular_function	zinc ion binding
A	0016874	molecular_function	ligase activity
A	0046872	molecular_function	metal ion binding
A	0106074	biological_process	aminoacyl-tRNA metabolism involved in translational fidelity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE K T 301

Chain	Residue
T	C32
T	U33
T	U36
T	A38
T	HOH1267

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1001

Chain	Residue
A	CYS886
A	CYS889
A	CYS906
A	CYS909

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1992

Chain	Residue
A	ASP13
A	HIS201
A	HIS770
A	HOH2070

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG T 1201

Chain	Residue
T	HOH1292
T	HOH1293
T	HOH1294
T	HOH1295
T	HOH1296
T	HOH1297

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG T 1202

Chain	Residue
T	HOH1298
T	HOH1299
T	HOH1300
T	HOH1301
T	HOH1302
T	HOH1303

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG T 1203

Chain	Residue
A	HOH2198
T	A14
T	HOH1304
T	HOH1305
T	HOH1306
T	HOH1307

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE MG T 1204

Chain	Residue
T	G26
T	G43
T	A44
T	HOH1218
T	HOH1308
T	HOH1309
T	HOH1310
T	HOH1311

---

site_id	AC8
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG T 1205

Chain	Residue
A	ASN713
A	ASN718
A	HOH2199
T	C25
T	HOH1312
T	HOH1313
T	HOH1314

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG T 1206

Chain	Residue
T	U8
T	A9
T	HOH1315
T	HOH1316
T	HOH1317
T	HOH1318

---

site_id	BC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG T 1207

Chain	Residue
T	G16
T	G19
T	G59
T	U60
T	HOH1250
T	HOH1319
T	HOH1320

---

site_id	BC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG T 1208

Chain	Residue
A	ASN703
A	HOH2200
A	HOH2201
T	C13
T	A14
T	HOH1321
T	HOH1322

---

site_id	BC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG T 1209

Chain	Residue
T	U47
T	C48
T	G50
T	HOH1323
T	HOH1324
T	HOH1325
T	HOH1326

---

site_id	BC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE MG T 1210

Chain	Residue
T	U8
T	U12
T	HOH1318
T	HOH1327
T	HOH1328
T	HOH1329
T	HOH1330

---

site_id	BC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE MRC A 1993

Chain	Residue
A	PRO56
A	HIS64
A	HIS67
A	GLU554
A	GLY555
A	ASP557
A	GLN558
A	TRP562
A	HIS585
A	GLY586
A	PHE587
A	VAL588
A	MET596
A	SER597
A	HOH2052
A	HOH2085
A	HOH2116
A	HOH2138

---

Functional Information from PROSITE/UniProt

site_id	PS00178
Number of Residues	12
Details	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PyaNGnLHMGHA

Chain	Residue	Details
A	PRO57-ALA68

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000250|UniProtKB:P56690

Chain	Residue	Details
A	ASP557
A	GLN558
A	HIS585
A	PRO56
A	HIS67
A	GLU554
A	GLY555

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	LYS598

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:1QU2

Chain	Residue	Details
A	GLN640
A	ARG632

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0007744|PDB:1FFY, ECO:0007744|PDB:1QU2

Chain	Residue	Details
A	CYS889
A	CYS906
A	CYS909
A	CYS886

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