1PE0

Crystal structure of the K130R mutant of human DJ-1

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Functional Information from GO Data

ChainGOidnamespacecontents
A0030424cellular_componentaxon
A0044297cellular_componentcell body
A0005913cellular_componentcell-cell adherens junction
A0000785cellular_componentchromatin
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005783cellular_componentendoplasmic reticulum
A0070062cellular_componentextracellular exosome
A0045121cellular_componentmembrane raft
A0005758cellular_componentmitochondrial intermembrane space
A0005759cellular_componentmitochondrial matrix
A0005739cellular_componentmitochondrion
A0005654cellular_componentnucleoplasm
A0005634cellular_componentnucleus
A0048471cellular_componentperinuclear region of cytoplasm
A0005886cellular_componentplasma membrane
A0016605cellular_componentPML body
A0098793cellular_componentpresynapse
A0050681molecular_functionandrogen receptor binding
A0045296molecular_functioncadherin binding
A0005507molecular_functioncopper ion binding
A1903135molecular_functioncupric ion binding
A1903136molecular_functioncuprous ion binding
A0019955molecular_functioncytokine binding
A0019899molecular_functionenzyme binding
A0042802molecular_functionidentical protein binding
A0019900molecular_functionkinase binding
A0036478molecular_functionL-dopa decarboxylase activator activity
A0045340molecular_functionmercury ion binding
A0003729molecular_functionmRNA binding
A0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
A0008233molecular_functionpeptidase activity
A0051920molecular_functionperoxiredoxin activity
A0036524molecular_functionprotein deglycase activity
A0042803molecular_functionprotein homodimerization activity
A0044877molecular_functionprotein-containing complex binding
A0070491molecular_functionrepressing transcription factor binding
A0097110molecular_functionscaffold protein binding
A0005102molecular_functionsignaling receptor binding
A0044388molecular_functionsmall protein activating enzyme binding
A0016532molecular_functionsuperoxide dismutase copper chaperone activity
A0003713molecular_functiontranscription coactivator activity
A0008134molecular_functiontranscription factor binding
A0036470molecular_functiontyrosine 3-monooxygenase activator activity
A0044390molecular_functionubiquitin-like protein conjugating enzyme binding
A1990381molecular_functionubiquitin-specific protease binding
A0032148biological_processactivation of protein kinase B activity
A0008344biological_processadult locomotory behavior
A0006914biological_processautophagy
A0036471biological_processcellular response to glyoxal
A0070301biological_processcellular response to hydrogen peroxide
A0034599biological_processcellular response to oxidative stress
A0010273biological_processdetoxification of copper ion
A0050787biological_processdetoxification of mercury ion
A0006281biological_processDNA repair
A0051583biological_processdopamine uptake involved in synaptic transmission
A0018323biological_processenzyme active site formation via L-cysteine sulfinic acid
A0042593biological_processglucose homeostasis
A0036531biological_processglutathione deglycation
A0046295biological_processglycolate biosynthetic process
A1903189biological_processglyoxal metabolic process
A0106044biological_processguanine deglycation
A0106046biological_processguanine deglycation, glyoxal removal
A0106045biological_processguanine deglycation, methylglyoxal removal
A0042743biological_processhydrogen peroxide metabolic process
A0006954biological_processinflammatory response
A0030073biological_processinsulin secretion
A0019249biological_processlactate biosynthetic process
A0051899biological_processmembrane depolarization
A0060081biological_processmembrane hyperpolarization
A0009438biological_processmethylglyoxal metabolic process
A0007005biological_processmitochondrion organization
A0043066biological_processnegative regulation of apoptotic process
A0060548biological_processnegative regulation of cell death
A2001268biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
A1903073biological_processnegative regulation of death-inducing signaling complex assembly
A1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
A0010629biological_processnegative regulation of gene expression
A1903206biological_processnegative regulation of hydrogen peroxide-induced cell death
A1903208biological_processnegative regulation of hydrogen peroxide-induced neuron death
A1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
A0043524biological_processnegative regulation of neuron apoptotic process
A1901215biological_processnegative regulation of neuron death
A1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
A1903202biological_processnegative regulation of oxidative stress-induced cell death
A1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A1901984biological_processnegative regulation of protein acetylation
A0032091biological_processnegative regulation of protein binding
A0046826biological_processnegative regulation of protein export from nucleus
A1903094biological_processnegative regulation of protein K48-linked deubiquitination
A0006469biological_processnegative regulation of protein kinase activity
A0001933biological_processnegative regulation of protein phosphorylation
A0033234biological_processnegative regulation of protein sumoylation
A0031397biological_processnegative regulation of protein ubiquitination
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
A0051444biological_processnegative regulation of ubiquitin-protein transferase activity
A2000157biological_processnegative regulation of ubiquitin-specific protease activity
A0036527biological_processpeptidyl-arginine deglycation
A0036526biological_processpeptidyl-cysteine deglycation
A0036528biological_processpeptidyl-lysine deglycation
A0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
A2000825biological_processpositive regulation of androgen receptor activity
A1903599biological_processpositive regulation of autophagy of mitochondrion
A0051091biological_processpositive regulation of DNA-binding transcription factor activity
A1903181biological_processpositive regulation of dopamine biosynthetic process
A0010628biological_processpositive regulation of gene expression
A0032757biological_processpositive regulation of interleukin-8 production
A1903197biological_processpositive regulation of L-dopa biosynthetic process
A1903200biological_processpositive regulation of L-dopa decarboxylase activity
A1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
A0033864biological_processpositive regulation of NAD(P)H oxidase activity
A2000277biological_processpositive regulation of oxidative phosphorylation uncoupler activity
A1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0090073biological_processpositive regulation of protein homodimerization activity
A0051897biological_processpositive regulation of protein kinase B signaling
A1900182biological_processpositive regulation of protein localization to nucleus
A1903168biological_processpositive regulation of pyrroline-5-carboxylate reductase activity
A1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
A1901671biological_processpositive regulation of superoxide dismutase activity
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A2000679biological_processpositive regulation of transcription regulatory region DNA binding
A1903178biological_processpositive regulation of tyrosine 3-monooxygenase activity
A0036529biological_processprotein deglycation, glyoxal removal
A0036530biological_processprotein deglycation, methylglyoxal removal
A0006517biological_processprotein deglycosylation
A0050821biological_processprotein stabilization
A0007265biological_processRas protein signal transduction
A0060765biological_processregulation of androgen receptor signaling pathway
A0050727biological_processregulation of inflammatory response
A0051881biological_processregulation of mitochondrial membrane potential
A0043523biological_processregulation of neuron apoptotic process
A1902903biological_processregulation of supramolecular fiber organization
A0007338biological_processsingle fertilization
B0030424cellular_componentaxon
B0044297cellular_componentcell body
B0005913cellular_componentcell-cell adherens junction
B0000785cellular_componentchromatin
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0005783cellular_componentendoplasmic reticulum
B0070062cellular_componentextracellular exosome
B0045121cellular_componentmembrane raft
B0005758cellular_componentmitochondrial intermembrane space
B0005759cellular_componentmitochondrial matrix
B0005739cellular_componentmitochondrion
B0005654cellular_componentnucleoplasm
B0005634cellular_componentnucleus
B0048471cellular_componentperinuclear region of cytoplasm
B0005886cellular_componentplasma membrane
B0016605cellular_componentPML body
B0098793cellular_componentpresynapse
B0050681molecular_functionandrogen receptor binding
B0045296molecular_functioncadherin binding
B0005507molecular_functioncopper ion binding
B1903135molecular_functioncupric ion binding
B1903136molecular_functioncuprous ion binding
B0019955molecular_functioncytokine binding
B0019899molecular_functionenzyme binding
B0042802molecular_functionidentical protein binding
B0019900molecular_functionkinase binding
B0036478molecular_functionL-dopa decarboxylase activator activity
B0045340molecular_functionmercury ion binding
B0003729molecular_functionmRNA binding
B0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
B0008233molecular_functionpeptidase activity
B0051920molecular_functionperoxiredoxin activity
B0036524molecular_functionprotein deglycase activity
B0042803molecular_functionprotein homodimerization activity
B0044877molecular_functionprotein-containing complex binding
B0070491molecular_functionrepressing transcription factor binding
B0097110molecular_functionscaffold protein binding
B0005102molecular_functionsignaling receptor binding
B0044388molecular_functionsmall protein activating enzyme binding
B0016532molecular_functionsuperoxide dismutase copper chaperone activity
B0003713molecular_functiontranscription coactivator activity
B0008134molecular_functiontranscription factor binding
B0036470molecular_functiontyrosine 3-monooxygenase activator activity
B0044390molecular_functionubiquitin-like protein conjugating enzyme binding
B1990381molecular_functionubiquitin-specific protease binding
B0032148biological_processactivation of protein kinase B activity
B0008344biological_processadult locomotory behavior
B0006914biological_processautophagy
B0036471biological_processcellular response to glyoxal
B0070301biological_processcellular response to hydrogen peroxide
B0034599biological_processcellular response to oxidative stress
B0010273biological_processdetoxification of copper ion
B0050787biological_processdetoxification of mercury ion
B0006281biological_processDNA repair
B0051583biological_processdopamine uptake involved in synaptic transmission
B0018323biological_processenzyme active site formation via L-cysteine sulfinic acid
B0042593biological_processglucose homeostasis
B0036531biological_processglutathione deglycation
B0046295biological_processglycolate biosynthetic process
B1903189biological_processglyoxal metabolic process
B0106044biological_processguanine deglycation
B0106046biological_processguanine deglycation, glyoxal removal
B0106045biological_processguanine deglycation, methylglyoxal removal
B0042743biological_processhydrogen peroxide metabolic process
B0006954biological_processinflammatory response
B0030073biological_processinsulin secretion
B0019249biological_processlactate biosynthetic process
B0051899biological_processmembrane depolarization
B0060081biological_processmembrane hyperpolarization
B0009438biological_processmethylglyoxal metabolic process
B0007005biological_processmitochondrion organization
B0043066biological_processnegative regulation of apoptotic process
B0060548biological_processnegative regulation of cell death
B2001268biological_processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
B1903073biological_processnegative regulation of death-inducing signaling complex assembly
B1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
B2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
B0010629biological_processnegative regulation of gene expression
B1903206biological_processnegative regulation of hydrogen peroxide-induced cell death
B1903208biological_processnegative regulation of hydrogen peroxide-induced neuron death
B1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
B0043524biological_processnegative regulation of neuron apoptotic process
B1901215biological_processnegative regulation of neuron death
B1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
B1903202biological_processnegative regulation of oxidative stress-induced cell death
B1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
B0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
B1901984biological_processnegative regulation of protein acetylation
B0032091biological_processnegative regulation of protein binding
B0046826biological_processnegative regulation of protein export from nucleus
B1903094biological_processnegative regulation of protein K48-linked deubiquitination
B0006469biological_processnegative regulation of protein kinase activity
B0001933biological_processnegative regulation of protein phosphorylation
B0033234biological_processnegative regulation of protein sumoylation
B0031397biological_processnegative regulation of protein ubiquitination
B1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
B1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
B0051444biological_processnegative regulation of ubiquitin-protein transferase activity
B2000157biological_processnegative regulation of ubiquitin-specific protease activity
B0036527biological_processpeptidyl-arginine deglycation
B0036526biological_processpeptidyl-cysteine deglycation
B0036528biological_processpeptidyl-lysine deglycation
B0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
B2000825biological_processpositive regulation of androgen receptor activity
B1903599biological_processpositive regulation of autophagy of mitochondrion
B0051091biological_processpositive regulation of DNA-binding transcription factor activity
B1903181biological_processpositive regulation of dopamine biosynthetic process
B0010628biological_processpositive regulation of gene expression
B0032757biological_processpositive regulation of interleukin-8 production
B1903197biological_processpositive regulation of L-dopa biosynthetic process
B1903200biological_processpositive regulation of L-dopa decarboxylase activity
B1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
B0033864biological_processpositive regulation of NAD(P)H oxidase activity
B2000277biological_processpositive regulation of oxidative phosphorylation uncoupler activity
B1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0090073biological_processpositive regulation of protein homodimerization activity
B0051897biological_processpositive regulation of protein kinase B signaling
B1900182biological_processpositive regulation of protein localization to nucleus
B1903168biological_processpositive regulation of pyrroline-5-carboxylate reductase activity
B1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
B1901671biological_processpositive regulation of superoxide dismutase activity
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B2000679biological_processpositive regulation of transcription regulatory region DNA binding
B1903178biological_processpositive regulation of tyrosine 3-monooxygenase activity
B0036529biological_processprotein deglycation, glyoxal removal
B0036530biological_processprotein deglycation, methylglyoxal removal
B0006517biological_processprotein deglycosylation
B0050821biological_processprotein stabilization
B0007265biological_processRas protein signal transduction
B0060765biological_processregulation of androgen receptor signaling pathway
B0050727biological_processregulation of inflammatory response
B0051881biological_processregulation of mitochondrial membrane potential
B0043523biological_processregulation of neuron apoptotic process
B1902903biological_processregulation of supramolecular fiber organization
B0007338biological_processsingle fertilization
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI12Probable.
ChainResidueDetails
ACYS106
AHIS126

SWS_FT_FI22Probable.
ChainResidueDetails
BCYS106
BHIS126

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Catalytic Information from CSA

site_idNumber of ResiduesDetails