1P77

CRYSTAL STRUCTURE OF SHIKIMATE DEHYDROGENASE (AROE) FROM HAEMOPHILUS INFLUENZAE

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004764	molecular_function	shikimate 3-dehydrogenase (NADP+) activity
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0009073	biological_process	aromatic amino acid family biosynthetic process
A	0009423	biological_process	chorismate biosynthetic process
A	0016491	molecular_function	oxidoreductase activity
A	0019632	biological_process	shikimate metabolic process
A	0050661	molecular_function	NADP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE ACT A 301

Chain	Residue
A	MET1
A	LYS89
A	PRO177
A	GLN179
A	TRP253
A	ARG254
A	GLY255
A	HOH415

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site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ATR A 300

Chain	Residue
A	ALA127
A	GLY128
A	GLY129
A	ALA130
A	ASN149
A	ARG150
A	THR151
A	LYS154
A	THR188
A	SER189
A	ALA190
A	HOH348
A	HOH361
A	HOH445
A	HOH450
A	HOH485
A	HOH516
A	HOH535
A	GLY126

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_00222

Chain	Residue	Details
A	LYS65

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site_id	SWS_FT_FI2
Number of Residues	7
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00222

Chain	Residue	Details
A	SER14
A	THR61
A	ASN86
A	ASP102
A	MET213
A	TYR215
A	GLY238

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site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00222, ECO:0000269|PubMed:12837789

Chain	Residue	Details
A	GLY126
A	ASN149

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site_id	SWS_FT_FI4
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:12837789

Chain	Residue	Details
A	SER189

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