1O9S
Crystal structure of a ternary complex of the human histone methyltransferase SET7/9
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0005694 | cellular_component | chromosome |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| A | 0140945 | molecular_function | histone H3K4 monomethyltransferase activity |
| B | 0005694 | cellular_component | chromosome |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0016279 | molecular_function | protein-lysine N-methyltransferase activity |
| B | 0140945 | molecular_function | histone H3K4 monomethyltransferase activity |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 17 |
| 詳細 | BINDING SITE FOR RESIDUE SAH A1367 |
| 鎖名 | 残基 |
| A | ALA226 |
| A | GLU356 |
| A | HOH2302 |
| A | HOH2303 |
| A | HOH2307 |
| A | HOH2308 |
| A | HOH2309 |
| A | HOH2310 |
| K | MLZ4 |
| A | GLU228 |
| A | ASN265 |
| A | HIS293 |
| A | LYS294 |
| A | ASN296 |
| A | HIS297 |
| A | TYR335 |
| A | TRP352 |
| site_id | AC2 |
| 残基数 | 17 |
| 詳細 | BINDING SITE FOR RESIDUE SAH B1367 |
| 鎖名 | 残基 |
| B | ALA226 |
| B | GLU228 |
| B | ASN265 |
| B | HIS293 |
| B | LYS294 |
| B | ASN296 |
| B | HIS297 |
| B | TYR335 |
| B | TRP352 |
| B | GLU356 |
| B | HOH2322 |
| B | HOH2324 |
| B | HOH2325 |
| B | HOH2326 |
| B | HOH2327 |
| B | HOH2328 |
| L | MLZ4 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 2 |
| 詳細 | MOD_RES: Citrulline; alternate => ECO:0000269|PubMed:16567635 |
| 鎖名 | 残基 | 詳細 |
| A | HIS297 | |
| B | ALA226 | |
| B | ASN296 | |
| B | HIS297 | |
| K | ARG2 | |
| L | ARG2 |
| site_id | SWS_FT_FI2 |
| 残基数 | 2 |
| 詳細 | MOD_RES: Phosphothreonine; by HASPIN => ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088 |
| 鎖名 | 残基 | 詳細 |
| K | THR3 | |
| L | THR3 |
| site_id | SWS_FT_FI3 |
| 残基数 | 2 |
| 詳細 | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| 鎖名 | 残基 | 詳細 |
| A | THR266 | |
| A | LYS317 | |
| A | TYR335 | |
| B | TYR245 | |
| B | ASP256 | |
| B | THR266 | |
| B | LYS317 | |
| B | TYR335 | |
| K | MLZ4 | |
| L | MLZ4 |
| site_id | SWS_FT_FI4 |
| 残基数 | 2 |
| 詳細 | MOD_RES: 5-glutamyl serotonin; alternate => ECO:0000269|PubMed:30867594 |
| 鎖名 | 残基 | 詳細 |
| K | GLN5 | |
| L | GLN5 |
| site_id | SWS_FT_FI5 |
| 残基数 | 2 |
| 詳細 | MOD_RES: Phosphothreonine; by PKC => ECO:0000269|PubMed:20228790 |
| 鎖名 | 残基 | 詳細 |
| K | THR6 | |
| L | THR6 |
| site_id | SWS_FT_FI6 |
| 残基数 | 2 |
| 詳細 | MOD_RES: Symmetric dimethylarginine; by PRMT5; alternate => ECO:0000250|UniProtKB:P68433 |
| 鎖名 | 残基 | 詳細 |
| K | ARG8 | |
| L | ARG8 |
| site_id | SWS_FT_FI7 |
| 残基数 | 2 |
| 詳細 | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16267050, ECO:0000269|PubMed:16457588, ECO:0000269|PubMed:17194708 |
| 鎖名 | 残基 | 詳細 |
| K | LYS9 | |
| L | LYS9 |
| site_id | SWS_FT_FI8 |
| 残基数 | 2 |
| 詳細 | MOD_RES: Phosphoserine; alternate; by AURKB, AURKC, RPS6KA3, RPS6KA4 and RPS6KA5 => ECO:0000269|PubMed:10464286, ECO:0000269|PubMed:11856369, ECO:0000269|PubMed:12560483, ECO:0000269|PubMed:15681610, ECO:0000269|PubMed:16185088, ECO:0000269|PubMed:16457588 |
| 鎖名 | 残基 | 詳細 |
| K | TYR10 | |
| L | TYR10 |
CSAにおける酵素触媒機能の情報
| site_id | MCSA1 |
| 残基数 | 5 |
| 詳細 | M-CSA 350 |
| 鎖名 | 残基 | 詳細 |
| A | TYR245 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| A | HIS293 | electrostatic stabiliser, hydrogen bond acceptor |
| A | HIS297 | electrostatic stabiliser, hydrogen bond acceptor |
| A | TYR305 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| A | TYR335 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
| site_id | MCSA2 |
| 残基数 | 5 |
| 詳細 | M-CSA 350 |
| 鎖名 | 残基 | 詳細 |
| B | TYR245 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor |
| B | HIS293 | electrostatic stabiliser, hydrogen bond acceptor |
| B | HIS297 | electrostatic stabiliser, hydrogen bond acceptor |
| B | TYR305 | activator, electrostatic stabiliser, hydrogen bond acceptor |
| B | TYR335 | activator, electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor |
