Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1NSQ

MECHANISM OF PHOSPHATE TRANSFER BY NUCLEOSIDE DIPHOSPHATE KINASE: X-RAY STRUCTURES OF A PHOSPHO-HISTIDINE INTERMEDIATE OF THE ENZYMES FROM DROSOPHILA AND DICTYOSTELIUM

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000278	biological_process	mitotic cell cycle
A	0000287	molecular_function	magnesium ion binding
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005524	molecular_function	ATP binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0005880	cellular_component	nuclear microtubule
A	0005886	cellular_component	plasma membrane
A	0006183	biological_process	GTP biosynthetic process
A	0006228	biological_process	UTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0007017	biological_process	microtubule-based process
A	0007424	biological_process	open tracheal system development
A	0007427	biological_process	epithelial cell migration, open tracheal system
A	0008017	molecular_function	microtubule binding
A	0009117	biological_process	nucleotide metabolic process
A	0009142	biological_process	nucleoside triphosphate biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016334	biological_process	establishment or maintenance of polarity of follicular epithelium
A	0016740	molecular_function	transferase activity
A	0034332	biological_process	adherens junction organization
A	0035152	biological_process	regulation of tube architecture, open tracheal system
A	0046872	molecular_function	metal ion binding
B	0000166	molecular_function	nucleotide binding
B	0000278	biological_process	mitotic cell cycle
B	0000287	molecular_function	magnesium ion binding
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005524	molecular_function	ATP binding
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0005880	cellular_component	nuclear microtubule
B	0005886	cellular_component	plasma membrane
B	0006183	biological_process	GTP biosynthetic process
B	0006228	biological_process	UTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0007017	biological_process	microtubule-based process
B	0007424	biological_process	open tracheal system development
B	0007427	biological_process	epithelial cell migration, open tracheal system
B	0008017	molecular_function	microtubule binding
B	0009117	biological_process	nucleotide metabolic process
B	0009142	biological_process	nucleoside triphosphate biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016334	biological_process	establishment or maintenance of polarity of follicular epithelium
B	0016740	molecular_function	transferase activity
B	0034332	biological_process	adherens junction organization
B	0035152	biological_process	regulation of tube architecture, open tracheal system
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000278	biological_process	mitotic cell cycle
C	0000287	molecular_function	magnesium ion binding
C	0004550	molecular_function	nucleoside diphosphate kinase activity
C	0005524	molecular_function	ATP binding
C	0005525	molecular_function	GTP binding
C	0005737	cellular_component	cytoplasm
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0005880	cellular_component	nuclear microtubule
C	0005886	cellular_component	plasma membrane
C	0006183	biological_process	GTP biosynthetic process
C	0006228	biological_process	UTP biosynthetic process
C	0006241	biological_process	CTP biosynthetic process
C	0007017	biological_process	microtubule-based process
C	0007424	biological_process	open tracheal system development
C	0007427	biological_process	epithelial cell migration, open tracheal system
C	0008017	molecular_function	microtubule binding
C	0009117	biological_process	nucleotide metabolic process
C	0009142	biological_process	nucleoside triphosphate biosynthetic process
C	0016301	molecular_function	kinase activity
C	0016310	biological_process	phosphorylation
C	0016334	biological_process	establishment or maintenance of polarity of follicular epithelium
C	0016740	molecular_function	transferase activity
C	0034332	biological_process	adherens junction organization
C	0035152	biological_process	regulation of tube architecture, open tracheal system
C	0046872	molecular_function	metal ion binding

Functional Information from PROSITE/UniProt

site_id	PS00469
Number of Residues	9
Details	NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NiiHGSDAV

Chain	Residue	Details
A	ASN116-VAL124

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	ACT_SITE: Pros-phosphohistidine intermediate

Chain	Residue	Details
A	HIP119
B	HIP119
C	HIP119

site_id	SWS_FT_FI2
Number of Residues	18
Details	BINDING:

Chain	Residue	Details
A	LYS13
A	PHE61
A	ARG89
A	THR95
A	ARG106
A	ASN116
B	LYS13
B	PHE61
B	ARG89
B	THR95
B	ARG106
B	ASN116
C	LYS13
C	PHE61
C	ARG89
C	THR95
C	ARG106
C	ASN116

site_id	SWS_FT_FI3
Number of Residues	3
Details	MOD_RES: N-acetylalanine => ECO:0000269\|PubMed:12099695

Chain	Residue	Details
A	ALA2
B	ALA2
C	ALA2

site_id	SWS_FT_FI4
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000269\|PubMed:18327897

Chain	Residue	Details
A	SER126
B	SER126
C	SER126

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)