1NIH

Structure of deoxy-quaternary haemoglobin with liganded beta subunits

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005506	molecular_function	iron ion binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005829	cellular_component	cytosol
A	0005833	cellular_component	hemoglobin complex
A	0015670	biological_process	carbon dioxide transport
A	0015671	biological_process	oxygen transport
A	0016020	cellular_component	membrane
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0030185	biological_process	nitric oxide transport
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042542	biological_process	response to hydrogen peroxide
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0071682	cellular_component	endocytic vesicle lumen
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005829	cellular_component	cytosol
B	0005833	cellular_component	hemoglobin complex
B	0008217	biological_process	regulation of blood pressure
B	0015670	biological_process	carbon dioxide transport
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0030185	biological_process	nitric oxide transport
B	0030492	molecular_function	hemoglobin binding
B	0031720	molecular_function	haptoglobin binding
B	0031721	molecular_function	hemoglobin alpha binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042542	biological_process	response to hydrogen peroxide
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0043177	molecular_function	organic acid binding
B	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0070293	biological_process	renal absorption
B	0070527	biological_process	platelet aggregation
B	0071682	cellular_component	endocytic vesicle lumen
B	0072562	cellular_component	blood microparticle
B	0097746	biological_process	blood vessel diameter maintenance
B	0098869	biological_process	cellular oxidant detoxification
B	1904724	cellular_component	tertiary granule lumen
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0004601	molecular_function	peroxidase activity
C	0005344	molecular_function	oxygen carrier activity
C	0005506	molecular_function	iron ion binding
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005829	cellular_component	cytosol
C	0005833	cellular_component	hemoglobin complex
C	0015670	biological_process	carbon dioxide transport
C	0015671	biological_process	oxygen transport
C	0016020	cellular_component	membrane
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0030185	biological_process	nitric oxide transport
C	0031720	molecular_function	haptoglobin binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0042542	biological_process	response to hydrogen peroxide
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0043177	molecular_function	organic acid binding
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0071682	cellular_component	endocytic vesicle lumen
C	0072562	cellular_component	blood microparticle
C	0098869	biological_process	cellular oxidant detoxification
D	0004601	molecular_function	peroxidase activity
D	0005344	molecular_function	oxygen carrier activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005829	cellular_component	cytosol
D	0005833	cellular_component	hemoglobin complex
D	0008217	biological_process	regulation of blood pressure
D	0015670	biological_process	carbon dioxide transport
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0030185	biological_process	nitric oxide transport
D	0030492	molecular_function	hemoglobin binding
D	0031720	molecular_function	haptoglobin binding
D	0031721	molecular_function	hemoglobin alpha binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0042542	biological_process	response to hydrogen peroxide
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0043177	molecular_function	organic acid binding
D	0045429	biological_process	positive regulation of nitric oxide biosynthetic process
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0070293	biological_process	renal absorption
D	0070527	biological_process	platelet aggregation
D	0071682	cellular_component	endocytic vesicle lumen
D	0072562	cellular_component	blood microparticle
D	0097746	biological_process	blood vessel diameter maintenance
D	0098869	biological_process	cellular oxidant detoxification
D	1904724	cellular_component	tertiary granule lumen
D	1904813	cellular_component	ficolin-1-rich granule lumen

PDBデータベースに由来する情報

site_id	AC1
残基数	12
詳細	BINDING SITE FOR RESIDUE HNI A 201

鎖名	残基
A	TYR42
A	VAL93
A	ASN97
A	LEU101
A	PHE43
A	HIS45
A	HIS58
A	LYS61
A	ALA65
A	LEU83
A	HIS87
A	LEU91

---

site_id	AC2
残基数	12
詳細	BINDING SITE FOR RESIDUE HEM B 201

鎖名	残基
B	PHE42
B	HIS63
B	VAL67
B	LEU91
B	HIS92
B	LEU96
B	ASN102
B	LEU141
B	CMO202
B	HOH743
D	LYS95
D	HOH737

---

site_id	AC3
残基数	3
詳細	BINDING SITE FOR RESIDUE CMO B 202

鎖名	残基
B	HIS63
B	VAL67
B	HEM201

---

site_id	AC4
残基数	11
詳細	BINDING SITE FOR RESIDUE HNI C 201

鎖名	残基
C	TYR42
C	PHE43
C	HIS45
C	HIS58
C	LYS61
C	LEU86
C	HIS87
C	LEU91
C	ASN97
C	LEU101
C	LEU136

---

site_id	AC5
残基数	10
詳細	BINDING SITE FOR RESIDUE HEM D 201

鎖名	残基
B	GLU43
D	PHE41
D	HIS63
D	LYS66
D	HIS92
D	LEU96
D	VAL98
D	ASN102
D	LEU141
D	CMO202

---

site_id	AC6
残基数	3
詳細	BINDING SITE FOR RESIDUE IHP B 203

鎖名	残基
B	VAL1
B	LYS82
D	LYS82

---

site_id	AC7
残基数	3
詳細	BINDING SITE FOR RESIDUE CMO D 202

鎖名	残基
D	HIS63
D	VAL67
D	HEM201

---

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	8
詳細	BINDING:

鎖名	残基	詳細
B	GLY83
B	LYS144
D	HIS2
D	LEU3
D	GLY83
D	LYS144
B	HIS2
B	LEU3

---

site_id	SWS_FT_FI2
残基数	2
詳細	BINDING: distal binding residue

鎖名	残基	詳細
B	GLY64
D	GLY64

---

site_id	SWS_FT_FI3
残基数	2
詳細	BINDING: proximal binding residue

鎖名	残基	詳細
C	ARG92
C	VAL107
C	LEU109
C	HIS122
B	CYS93
D	CYS93
A	GLY25
A	GLU30
A	PHE46
A	LEU48
A	ALA53
A	LYS56
A	LYS60
A	ARG92
A	VAL107
A	LEU109
A	HIS122
A	THR134
C	TRP14
C	GLY25
C	GLU30
C	PHE46
C	LEU48
C	ALA53
C	LYS56
C	LYS60
C	THR134
C	ASN9

---

site_id	SWS_FT_FI4
残基数	38
詳細	SITE: (Microbial infection) Cleavage; by N.americanus apr-2 => ECO:0000269|PubMed:12552433

鎖名	残基	詳細
B	PHE85
B	CYS93
B	LEU105
B	VAL111
B	LYS120
B	THR123
B	ALA129
B	LEU141
B	TYR145
D	LYS8
D	GLU26
D	ARG30
D	PRO36
D	THR38
D	GLY46
D	ALA53
D	ASN57
D	SER72
D	LEU75
D	PHE85
D	CYS93
D	LEU105
D	VAL111
D	LYS120
D	THR123
D	ALA129
D	LEU141
D	TYR145
B	LYS8
B	GLU26
B	ARG30
B	PRO36
B	THR38
B	GLY46
B	ALA53
B	ASN57
B	SER72
B	LEU75

---

site_id	SWS_FT_FI5
残基数	6
詳細	SITE: Not glycated => ECO:0000269|PubMed:7358733

鎖名	残基	詳細
B	VAL60
B	GLY83
B	LEU96
D	VAL60
D	GLY83
D	LEU96

---

site_id	SWS_FT_FI6
残基数	2
詳細	MOD_RES: N-pyruvate 2-iminyl-valine; in Hb A1b

鎖名	残基	詳細
B	HIS2
D	HIS2
A	THR41
C	THR8
C	VAL17
C	THR41

---

site_id	SWS_FT_FI7
残基数	4
詳細	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

鎖名	残基	詳細
D	ALA10
D	PHE45
B	ALA10
B	PHE45

---

site_id	SWS_FT_FI8
残基数	6
詳細	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569

鎖名	残基	詳細
D	PRO51
D	LEU88
B	ALA13
B	PRO51
B	LEU88
D	ALA13

---

site_id	SWS_FT_FI9
残基数	4
詳細	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:4531009

鎖名	残基	詳細
B	VAL60
B	GLY83
D	VAL60
D	GLY83

---

site_id	SWS_FT_FI10
残基数	2
詳細	MOD_RES: S-nitrosocysteine => ECO:0000269|PubMed:8637569, ECO:0000269|PubMed:9843411

鎖名	残基	詳細
D	ASP94
A	VAL132
A	LYS139
C	HIS103
C	LEU125
C	VAL132
C	LYS139
B	ASP94

---

site_id	SWS_FT_FI11
残基数	2
詳細	MOD_RES: N6-acetyllysine; alternate => ECO:0000269|PubMed:4531009

鎖名	残基	詳細
B	TYR145
D	TYR145
A	SER138
C	LEU109
C	VAL135
C	SER138

---

site_id	SWS_FT_FI12
残基数	2
詳細	CARBOHYD: N-linked (Glc) (glycation) valine; in Hb A1c => ECO:0000269|PubMed:635569

鎖名	残基	詳細
A	THR41
C	THR8
C	VAL17
C	THR41
B	HIS2
D	HIS2

---

site_id	SWS_FT_FI13
残基数	8
詳細	CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:7358733

鎖名	残基	詳細
B	VAL67
B	GLU121
D	SER9
D	VAL18
D	VAL67
D	GLU121
B	SER9
B	VAL18

---

site_id	SWS_FT_FI14
残基数	2
詳細	CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:7358733

鎖名	残基	詳細
B	TYR145
D	TYR145

---