1MB2

Crystal Structure of Tryptophanyl-tRNA Synthetase Complexed with Tryptophan in an Open Conformation

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0000166	molecular_function	nucleotide binding
A	0004812	molecular_function	aminoacyl-tRNA ligase activity
A	0004830	molecular_function	tryptophan-tRNA ligase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006412	biological_process	translation
A	0006418	biological_process	tRNA aminoacylation for protein translation
A	0006436	biological_process	tryptophanyl-tRNA aminoacylation
A	0016874	molecular_function	ligase activity
B	0000166	molecular_function	nucleotide binding
B	0004812	molecular_function	aminoacyl-tRNA ligase activity
B	0004830	molecular_function	tryptophan-tRNA ligase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006412	biological_process	translation
B	0006418	biological_process	tRNA aminoacylation for protein translation
B	0006436	biological_process	tryptophanyl-tRNA aminoacylation
B	0016874	molecular_function	ligase activity
C	0000166	molecular_function	nucleotide binding
C	0004812	molecular_function	aminoacyl-tRNA ligase activity
C	0004830	molecular_function	tryptophan-tRNA ligase activity
C	0005524	molecular_function	ATP binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0006412	biological_process	translation
C	0006418	biological_process	tRNA aminoacylation for protein translation
C	0006436	biological_process	tryptophanyl-tRNA aminoacylation
C	0016874	molecular_function	ligase activity
D	0000166	molecular_function	nucleotide binding
D	0004812	molecular_function	aminoacyl-tRNA ligase activity
D	0004830	molecular_function	tryptophan-tRNA ligase activity
D	0005524	molecular_function	ATP binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0006412	biological_process	translation
D	0006418	biological_process	tRNA aminoacylation for protein translation
D	0006436	biological_process	tryptophanyl-tRNA aminoacylation
D	0016874	molecular_function	ligase activity
E	0000166	molecular_function	nucleotide binding
E	0004812	molecular_function	aminoacyl-tRNA ligase activity
E	0004830	molecular_function	tryptophan-tRNA ligase activity
E	0005524	molecular_function	ATP binding
E	0005737	cellular_component	cytoplasm
E	0005829	cellular_component	cytosol
E	0006412	biological_process	translation
E	0006418	biological_process	tRNA aminoacylation for protein translation
E	0006436	biological_process	tryptophanyl-tRNA aminoacylation
E	0016874	molecular_function	ligase activity
F	0000166	molecular_function	nucleotide binding
F	0004812	molecular_function	aminoacyl-tRNA ligase activity
F	0004830	molecular_function	tryptophan-tRNA ligase activity
F	0005524	molecular_function	ATP binding
F	0005737	cellular_component	cytoplasm
F	0005829	cellular_component	cytosol
F	0006412	biological_process	translation
F	0006418	biological_process	tRNA aminoacylation for protein translation
F	0006436	biological_process	tryptophanyl-tRNA aminoacylation
F	0016874	molecular_function	ligase activity

PDBデータベースに由来する情報

site_id	AC1
残基数	8
詳細	BINDING SITE FOR RESIDUE TRP A 400

鎖名	残基
A	PHE5
A	GLY7
A	VAL40
A	HIS43
A	MET129
A	ASP132
A	VAL143
A	GLN147

---

site_id	AC2
残基数	8
詳細	BINDING SITE FOR RESIDUE TRP B 401

鎖名	残基
B	GLY7
B	GLN9
B	VAL40
B	HIS43
B	MET129
B	ASP132
B	GLN147
B	PHE5

---

site_id	AC3
残基数	8
詳細	BINDING SITE FOR RESIDUE TRP C 402

鎖名	残基
C	PHE5
C	GLY7
C	VAL40
C	HIS43
C	MET129
C	ASP132
C	VAL143
C	GLN147

---

site_id	AC4
残基数	9
詳細	BINDING SITE FOR RESIDUE TRP D 403

鎖名	残基
D	PHE5
D	GLY7
D	GLN9
D	VAL40
D	HIS43
D	MET129
D	ASP132
D	VAL141
D	GLN147

---

site_id	AC5
残基数	7
詳細	BINDING SITE FOR RESIDUE TRP E 404

鎖名	残基
E	PHE5
E	GLY7
E	HIS43
E	MET129
E	ASP132
E	VAL143
E	GLN147

---

site_id	AC6
残基数	8
詳細	BINDING SITE FOR RESIDUE TRP F 405

鎖名	残基
F	PHE5
F	GLY7
F	GLN9
F	HIS43
F	MET129
F	ASP132
F	VAL143
F	GLN147

---

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00178
残基数	10
詳細	AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. P..SGvITIGNY

鎖名	残基	詳細
A	PRO10-TYR19

---

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	36
詳細	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00140, ECO:0000269|PubMed:26555258, ECO:0007744|PDB:5DK4

鎖名	残基	詳細
A	GLN9
B	GLY144
B	ILE183
B	LYS192
C	GLN9
C	GLY17
C	ASP132
C	GLY144
C	ILE183
C	LYS192
D	GLN9
A	GLY17
D	GLY17
D	ASP132
D	GLY144
D	ILE183
D	LYS192
E	GLN9
E	GLY17
E	ASP132
E	GLY144
E	ILE183
A	ASP132
E	LYS192
F	GLN9
F	GLY17
F	ASP132
F	GLY144
F	ILE183
F	LYS192
A	GLY144
A	ILE183
A	LYS192
B	GLN9
B	GLY17
B	ASP132

---

CSAにおける酵素触媒機能の情報

site_id	MCSA1
残基数	3
詳細	M-CSA 481

鎖名	残基	詳細
A	LYS111	electrostatic stabiliser
A	LYS192	electrostatic stabiliser
A	LYS195	electrostatic stabiliser

---

site_id	MCSA2
残基数	3
詳細	M-CSA 481

鎖名	残基	詳細
B	LYS111	electrostatic stabiliser
B	LYS192	electrostatic stabiliser
B	LYS195	electrostatic stabiliser

---

site_id	MCSA3
残基数	3
詳細	M-CSA 481

鎖名	残基	詳細
C	LYS111	electrostatic stabiliser
C	LYS192	electrostatic stabiliser
C	LYS195	electrostatic stabiliser

---

site_id	MCSA4
残基数	3
詳細	M-CSA 481

鎖名	残基	詳細
D	LYS111	electrostatic stabiliser
D	LYS192	electrostatic stabiliser
D	LYS195	electrostatic stabiliser

---

site_id	MCSA5
残基数	3
詳細	M-CSA 481

鎖名	残基	詳細
E	LYS111	electrostatic stabiliser
E	LYS192	electrostatic stabiliser
E	LYS195	electrostatic stabiliser

---

site_id	MCSA6
残基数	3
詳細	M-CSA 481

鎖名	残基	詳細
F	LYS111	electrostatic stabiliser
F	LYS192	electrostatic stabiliser
F	LYS195	electrostatic stabiliser

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