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1LXL

NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, MINIMIZED AVERAGE STRUCTURE

GO(遺伝子オントロジー)由来の情報
鎖名GO(遺伝子オントロジー)id名前空間内容
A0001541biological_processovarian follicle development
A0001701biological_processin utero embryonic development
A0001836biological_processrelease of cytochrome c from mitochondria
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005741cellular_componentmitochondrial outer membrane
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005783cellular_componentendoplasmic reticulum
A0005813cellular_componentcentrosome
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0006897biological_processendocytosis
A0006915biological_processapoptotic process
A0006950biological_processresponse to stress
A0007005biological_processmitochondrion organization
A0007281biological_processgerm cell development
A0007283biological_processspermatogenesis
A0008584biological_processmale gonad development
A0008630biological_processintrinsic apoptotic signaling pathway in response to DNA damage
A0008637biological_processapoptotic mitochondrial changes
A0009314biological_processresponse to radiation
A0009566biological_processfertilization
A0009615biological_processresponse to virus
A0016020cellular_componentmembrane
A0019901molecular_functionprotein kinase binding
A0030672cellular_componentsynaptic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0031965cellular_componentnuclear membrane
A0031966cellular_componentmitochondrial membrane
A0032465biological_processregulation of cytokinesis
A0032946biological_processpositive regulation of mononuclear cell proliferation
A0034097biological_processresponse to cytokine
A0035234biological_processectopic germ cell programmed cell death
A0040008biological_processregulation of growth
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0042981biological_processregulation of apoptotic process
A0043066biological_processnegative regulation of apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0044565biological_processdendritic cell proliferation
A0045202cellular_componentsynapse
A0046898biological_processresponse to cycloheximide
A0046902biological_processregulation of mitochondrial membrane permeability
A0046982molecular_functionprotein heterodimerization activity
A0050673biological_processepithelial cell proliferation
A0051093biological_processnegative regulation of developmental process
A0051402biological_processneuron apoptotic process
A0051434molecular_functionBH3 domain binding
A0051607biological_processdefense response to virus
A0051881biological_processregulation of mitochondrial membrane potential
A0071230biological_processcellular response to amino acid stimulus
A0071312biological_processcellular response to alkaloid
A0071480biological_processcellular response to gamma radiation
A0071839biological_processapoptotic process in bone marrow cell
A0090201biological_processnegative regulation of release of cytochrome c from mitochondria
A0097048biological_processdendritic cell apoptotic process
A0097136cellular_componentBcl-2 family protein complex
A0097192biological_processextrinsic apoptotic signaling pathway in absence of ligand
A0097284biological_processhepatocyte apoptotic process
A1900118biological_processnegative regulation of execution phase of apoptosis
A1902042biological_processnegative regulation of extrinsic apoptotic signaling pathway via death domain receptors
A1902230biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
A1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A1903077biological_processnegative regulation of protein localization to plasma membrane
A2000242biological_processnegative regulation of reproductive process
A2000669biological_processnegative regulation of dendritic cell apoptotic process
A2001233biological_processregulation of apoptotic signaling pathway
A2001240biological_processnegative regulation of extrinsic apoptotic signaling pathway in absence of ligand
A2001243biological_processnegative regulation of intrinsic apoptotic signaling pathway
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
site_idPS01080
残基数19
詳細BH1 Apoptosis regulator, Bcl-2 family BH1 motif signature. LFrDGv.NWGRIVAFFsFGG
鎖名残基詳細
ALEU130-GLY148

site_idPS01258
残基数12
詳細BH2 Apoptosis regulator, Bcl-2 family BH2 motif signature. WIqenGGWDtFV
鎖名残基詳細
ATRP181-VAL192

site_idPS01259
残基数15
詳細BH3 Apoptosis regulator, Bcl-2 family BH3 motif signature. VkqaLReAGDEFELR
鎖名残基詳細
AVAL86-ARG100

site_idPS01260
残基数21
詳細BH4_1 Apoptosis regulator, Bcl-2 family BH4 motif signature. SNRELVvDFLSYKLSQKGYsW
鎖名残基詳細
ASER4-TRP24

SwissProt/UniProtに記載されている蛋白質分子機能情報
site_idSWS_FT_FI1
残基数1
詳細SITE: Cleavage; by caspase-1
鎖名残基詳細
AASP61

site_idSWS_FT_FI2
残基数1
詳細MOD_RES: Phosphoserine; by PLK3 => ECO:0000269|PubMed:21840391
鎖名残基詳細
ASER49

site_idSWS_FT_FI3
残基数1
詳細MOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:19917720
鎖名残基詳細
ASER62

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件を2024-04-17に公開中

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