Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

1LDN

STRUCTURE OF A TERNARY COMPLEX OF AN ALLOSTERIC LACTATE DEHYDROGENASE FROM BACILLUS STEAROTHERMOPHILUS AT 2.5 ANGSTROMS RESOLUTION

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004459	molecular_function	L-lactate dehydrogenase activity
A	0005737	cellular_component	cytoplasm
A	0006089	biological_process	lactate metabolic process
A	0006090	biological_process	pyruvate metabolic process
A	0006096	biological_process	glycolytic process
A	0008152	biological_process	metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
A	0019752	biological_process	carboxylic acid metabolic process
A	0051287	molecular_function	NAD binding
B	0003824	molecular_function	catalytic activity
B	0004459	molecular_function	L-lactate dehydrogenase activity
B	0005737	cellular_component	cytoplasm
B	0006089	biological_process	lactate metabolic process
B	0006090	biological_process	pyruvate metabolic process
B	0006096	biological_process	glycolytic process
B	0008152	biological_process	metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
B	0019752	biological_process	carboxylic acid metabolic process
B	0051287	molecular_function	NAD binding
C	0003824	molecular_function	catalytic activity
C	0004459	molecular_function	L-lactate dehydrogenase activity
C	0005737	cellular_component	cytoplasm
C	0006089	biological_process	lactate metabolic process
C	0006090	biological_process	pyruvate metabolic process
C	0006096	biological_process	glycolytic process
C	0008152	biological_process	metabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
C	0019752	biological_process	carboxylic acid metabolic process
C	0051287	molecular_function	NAD binding
D	0003824	molecular_function	catalytic activity
D	0004459	molecular_function	L-lactate dehydrogenase activity
D	0005737	cellular_component	cytoplasm
D	0006089	biological_process	lactate metabolic process
D	0006090	biological_process	pyruvate metabolic process
D	0006096	biological_process	glycolytic process
D	0008152	biological_process	metabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
D	0019752	biological_process	carboxylic acid metabolic process
D	0051287	molecular_function	NAD binding
E	0003824	molecular_function	catalytic activity
E	0004459	molecular_function	L-lactate dehydrogenase activity
E	0005737	cellular_component	cytoplasm
E	0006089	biological_process	lactate metabolic process
E	0006090	biological_process	pyruvate metabolic process
E	0006096	biological_process	glycolytic process
E	0008152	biological_process	metabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
E	0019752	biological_process	carboxylic acid metabolic process
E	0051287	molecular_function	NAD binding
F	0003824	molecular_function	catalytic activity
F	0004459	molecular_function	L-lactate dehydrogenase activity
F	0005737	cellular_component	cytoplasm
F	0006089	biological_process	lactate metabolic process
F	0006090	biological_process	pyruvate metabolic process
F	0006096	biological_process	glycolytic process
F	0008152	biological_process	metabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
F	0019752	biological_process	carboxylic acid metabolic process
F	0051287	molecular_function	NAD binding
G	0003824	molecular_function	catalytic activity
G	0004459	molecular_function	L-lactate dehydrogenase activity
G	0005737	cellular_component	cytoplasm
G	0006089	biological_process	lactate metabolic process
G	0006090	biological_process	pyruvate metabolic process
G	0006096	biological_process	glycolytic process
G	0008152	biological_process	metabolic process
G	0016491	molecular_function	oxidoreductase activity
G	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
G	0019752	biological_process	carboxylic acid metabolic process
G	0051287	molecular_function	NAD binding
H	0003824	molecular_function	catalytic activity
H	0004459	molecular_function	L-lactate dehydrogenase activity
H	0005737	cellular_component	cytoplasm
H	0006089	biological_process	lactate metabolic process
H	0006090	biological_process	pyruvate metabolic process
H	0006096	biological_process	glycolytic process
H	0008152	biological_process	metabolic process
H	0016491	molecular_function	oxidoreductase activity
H	0016616	molecular_function	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
H	0019752	biological_process	carboxylic acid metabolic process
H	0051287	molecular_function	NAD binding

Functional Information from PROSITE/UniProt

site_id	PS00064
Number of Residues	7
Details	L_LDH L-lactate dehydrogenase active site. IGEHGDT

Chain	Residue	Details
A	ILE190-THR196

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000255\|HAMAP-Rule:MF_00488, ECO:0000305\|PubMed:1731077, ECO:0007744\|PDB:1LDN

Chain	Residue	Details
A	HIS193
B	HIS193
C	HIS193
D	HIS193
E	HIS193
F	HIS193
G	HIS193
H	HIS193

site_id	SWS_FT_FI2
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00488, ECO:0000269\|PubMed:1731077, ECO:0000269\|PubMed:2330370, ECO:0007744\|PDB:1LDN, ECO:0007744\|PDB:2LDB

Chain	Residue	Details
C	ALA136
D	PHE30
D	ASP52
D	ALA136
E	PHE30
E	ASP52
E	ALA136
F	PHE30
F	ASP52
F	ALA136
G	PHE30
G	ASP52
G	ALA136
H	PHE30
H	ASP52
H	ALA136
A	PHE30
A	ASP52
A	ALA136
B	PHE30
B	ASP52
B	ALA136
C	PHE30
C	ASP52

site_id	SWS_FT_FI3
Number of Residues	48
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00488

Chain	Residue	Details
B	GLY97
B	GLN100
B	SER119
B	ASN138
C	LYS57
C	TYR83
C	GLY97
C	GLN100
C	SER119
C	ASN138
D	LYS57
D	TYR83
D	GLY97
D	GLN100
D	SER119
D	ASN138
E	LYS57
E	TYR83
E	GLY97
E	GLN100
E	SER119
E	ASN138
F	LYS57
F	TYR83
F	GLY97
F	GLN100
F	SER119
F	ASN138
G	LYS57
G	TYR83
G	GLY97
G	GLN100
G	SER119
G	ASN138
H	LYS57
H	TYR83
H	GLY97
H	GLN100
H	SER119
H	ASN138
A	LYS57
A	TYR83
A	GLY97
A	GLN100
A	SER119
A	ASN138
B	LYS57
B	TYR83

site_id	SWS_FT_FI4
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00488, ECO:0000305\|PubMed:1731077, ECO:0007744\|PDB:1LDN

Chain	Residue	Details
C	THR247
D	ARG106
D	ASP166
D	THR247
E	ARG106
E	ASP166
E	THR247
F	ARG106
F	ASP166
F	THR247
G	ARG106
G	ASP166
G	THR247
H	ARG106
H	ASP166
H	THR247
A	ARG106
A	ASP166
A	THR247
B	ARG106
B	ASP166
B	THR247
C	ARG106
C	ASP166

site_id	SWS_FT_FI5
Number of Residues	16
Details	BINDING: BINDING => ECO:0000269\|PubMed:1731077, ECO:0000269\|PubMed:2330370, ECO:0007744\|PDB:1LDN, ECO:0007744\|PDB:2LDB

Chain	Residue	Details
A	SER161
A	GLN183
B	SER161
B	GLN183
C	SER161
C	GLN183
D	SER161
D	GLN183
E	SER161
E	GLN183
F	SER161
F	GLN183
G	SER161
G	GLN183
H	SER161
H	GLN183

site_id	SWS_FT_FI6
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00488, ECO:0000269\|PubMed:2330370, ECO:0007744\|PDB:2LDB

Chain	Residue	Details
A	ARG171
B	ARG171
C	ARG171
D	ARG171
E	ARG171
F	ARG171
G	ARG171
H	ARG171

site_id	SWS_FT_FI7
Number of Residues	8
Details	MOD_RES: Phosphotyrosine => ECO:0000255\|HAMAP-Rule:MF_00488

Chain	Residue	Details
A	TYR238
B	TYR238
C	TYR238
D	TYR238
E	TYR238
F	TYR238
G	TYR238
H	TYR238

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)