1L9X

Structure of gamma-Glutamyl Hydrolase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005764	cellular_component	lysosome
A	0005773	cellular_component	vacuole
A	0008238	molecular_function	exopeptidase activity
A	0008242	molecular_function	omega peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0034722	molecular_function	gamma-glutamyl-peptidase activity
A	0035578	cellular_component	azurophil granule lumen
A	0035580	cellular_component	specific granule lumen
A	0042470	cellular_component	melanosome
A	0046900	biological_process	tetrahydrofolylpolyglutamate metabolic process
A	0070062	cellular_component	extracellular exosome
A	1904724	cellular_component	tertiary granule lumen
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005634	cellular_component	nucleus
B	0005764	cellular_component	lysosome
B	0005773	cellular_component	vacuole
B	0008238	molecular_function	exopeptidase activity
B	0008242	molecular_function	omega peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0034722	molecular_function	gamma-glutamyl-peptidase activity
B	0035578	cellular_component	azurophil granule lumen
B	0035580	cellular_component	specific granule lumen
B	0042470	cellular_component	melanosome
B	0046900	biological_process	tetrahydrofolylpolyglutamate metabolic process
B	0070062	cellular_component	extracellular exosome
B	1904724	cellular_component	tertiary granule lumen
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005634	cellular_component	nucleus
C	0005764	cellular_component	lysosome
C	0005773	cellular_component	vacuole
C	0008238	molecular_function	exopeptidase activity
C	0008242	molecular_function	omega peptidase activity
C	0016787	molecular_function	hydrolase activity
C	0034722	molecular_function	gamma-glutamyl-peptidase activity
C	0035578	cellular_component	azurophil granule lumen
C	0035580	cellular_component	specific granule lumen
C	0042470	cellular_component	melanosome
C	0046900	biological_process	tetrahydrofolylpolyglutamate metabolic process
C	0070062	cellular_component	extracellular exosome
C	1904724	cellular_component	tertiary granule lumen
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005634	cellular_component	nucleus
D	0005764	cellular_component	lysosome
D	0005773	cellular_component	vacuole
D	0008238	molecular_function	exopeptidase activity
D	0008242	molecular_function	omega peptidase activity
D	0016787	molecular_function	hydrolase activity
D	0034722	molecular_function	gamma-glutamyl-peptidase activity
D	0035578	cellular_component	azurophil granule lumen
D	0035580	cellular_component	specific granule lumen
D	0042470	cellular_component	melanosome
D	0046900	biological_process	tetrahydrofolylpolyglutamate metabolic process
D	0070062	cellular_component	extracellular exosome
D	1904724	cellular_component	tertiary granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BME A 1001

Chain	Residue
A	ASP77
A	LEU78
A	ARG79
A	CYS124

---

site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE BME B 1002

Chain	Residue
B	HIS220
B	HOH1061
B	GLY73
B	GLY74
B	CYS110
B	LEU111
B	PHE170

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME B 1003

Chain	Residue
B	LEU118
B	CYS124
B	LEU126

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE BME C 1004

Chain	Residue
C	GLY73
C	GLY74
C	CYS110
C	LEU111
C	PHE170
C	HIS220

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME C 1005

Chain	Residue
C	LEU118
C	CYS124
C	LEU126

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BME D 1006

Chain	Residue
D	GLU114
D	CYS124
D	LEU126

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	ACT_SITE: Nucleophile

Chain	Residue	Details
A	CYS110
B	CYS110
C	CYS110
D	CYS110

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	ACT_SITE: Proton donor

Chain	Residue	Details
A	HIS220
B	HIS220
C	HIS220
D	HIS220

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN92
B	ASN92
C	ASN92
D	ASN92

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:11953431

Chain	Residue	Details
A	ASN139
A	ASN179
B	ASN139
B	ASN179
C	ASN139
C	ASN179
D	ASN139
D	ASN179

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine; partial => ECO:0000269|PubMed:11953431

Chain	Residue	Details
A	ASN283
B	ASN283
C	ASN283
D	ASN283

---

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	3
Details	M-CSA 747

Chain	Residue	Details
A	CYS110	nucleofuge, nucleophile, proton acceptor, proton donor
A	HIS220	proton acceptor, proton donor
A	GLU222	electrostatic stabiliser

---

site_id	MCSA2
Number of Residues	3
Details	M-CSA 747

Chain	Residue	Details
B	CYS110	nucleofuge, nucleophile, proton acceptor, proton donor
B	HIS220	proton acceptor, proton donor
B	GLU222	electrostatic stabiliser

---

site_id	MCSA3
Number of Residues	3
Details	M-CSA 747

Chain	Residue	Details
C	CYS110	nucleofuge, nucleophile, proton acceptor, proton donor
C	HIS220	proton acceptor, proton donor
C	GLU222	electrostatic stabiliser

---

site_id	MCSA4
Number of Residues	3
Details	M-CSA 747

Chain	Residue	Details
D	CYS110	nucleofuge, nucleophile, proton acceptor, proton donor
D	HIS220	proton acceptor, proton donor
D	GLU222	electrostatic stabiliser

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