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1KV3

HUMAN TISSUE TRANSGLUTAMINASE IN GDP BOUND FORM

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000785cellular_componentchromatin
A0000786cellular_componentnucleosome
A0003810molecular_functionprotein-glutamine gamma-glutamyltransferase activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005576cellular_componentextracellular region
A0005634cellular_componentnucleus
A0005694cellular_componentchromosome
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005925cellular_componentfocal adhesion
A0006338biological_processchromatin remodeling
A0006508biological_processproteolysis
A0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
A0008233molecular_functionpeptidase activity
A0010467biological_processgene expression
A0014046biological_processdopamine secretion
A0016020cellular_componentmembrane
A0016740molecular_functiontransferase activity
A0016746molecular_functionacyltransferase activity
A0016787molecular_functionhydrolase activity
A0018149biological_processpeptide cross-linking
A0018277biological_processprotein deamination
A0031012cellular_componentextracellular matrix
A0032471biological_processnegative regulation of endoplasmic reticulum calcium ion concentration
A0042981biological_processregulation of apoptotic process
A0043065biological_processpositive regulation of apoptotic process
A0043277biological_processapoptotic cell clearance
A0043547biological_processpositive regulation of GTPase activity
A0045785biological_processpositive regulation of cell adhesion
A0046872molecular_functionmetal ion binding
A0048471cellular_componentperinuclear region of cytoplasm
A0050568molecular_functionprotein-glutamine glutaminase activity
A0050769biological_processpositive regulation of neurogenesis
A0051057biological_processpositive regulation of small GTPase mediated signal transduction
A0051561biological_processpositive regulation of mitochondrial calcium ion concentration
A0060348biological_processbone development
A0060445biological_processbranching involved in salivary gland morphogenesis
A0060662biological_processsalivary gland cavitation
A0062023cellular_componentcollagen-containing extracellular matrix
A0070062cellular_componentextracellular exosome
A0071314biological_processcellular response to cocaine
A0120294molecular_functionpeptide serotonyltransferase activity
A0120295molecular_functionhistone serotonyltransferase activity
A0120296molecular_functionpeptide dopaminyltransferase activity
A0120297molecular_functionhistone dopaminyltransferase activity
A0120298molecular_functionpeptide noradrenalinyltransferase activity
A0120299molecular_functionpeptide histaminyltransferase activity
A1903351biological_processcellular response to dopamine
A1904015biological_processcellular response to serotonin
A2000425biological_processregulation of apoptotic cell clearance
B0000166molecular_functionnucleotide binding
B0000785cellular_componentchromatin
B0000786cellular_componentnucleosome
B0003810molecular_functionprotein-glutamine gamma-glutamyltransferase activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005576cellular_componentextracellular region
B0005634cellular_componentnucleus
B0005694cellular_componentchromosome
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006338biological_processchromatin remodeling
B0006508biological_processproteolysis
B0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
B0008233molecular_functionpeptidase activity
B0010467biological_processgene expression
B0014046biological_processdopamine secretion
B0016020cellular_componentmembrane
B0016740molecular_functiontransferase activity
B0016746molecular_functionacyltransferase activity
B0016787molecular_functionhydrolase activity
B0018149biological_processpeptide cross-linking
B0018277biological_processprotein deamination
B0031012cellular_componentextracellular matrix
B0032471biological_processnegative regulation of endoplasmic reticulum calcium ion concentration
B0042981biological_processregulation of apoptotic process
B0043065biological_processpositive regulation of apoptotic process
B0043277biological_processapoptotic cell clearance
B0043547biological_processpositive regulation of GTPase activity
B0045785biological_processpositive regulation of cell adhesion
B0046872molecular_functionmetal ion binding
B0048471cellular_componentperinuclear region of cytoplasm
B0050568molecular_functionprotein-glutamine glutaminase activity
B0050769biological_processpositive regulation of neurogenesis
B0051057biological_processpositive regulation of small GTPase mediated signal transduction
B0051561biological_processpositive regulation of mitochondrial calcium ion concentration
B0060348biological_processbone development
B0060445biological_processbranching involved in salivary gland morphogenesis
B0060662biological_processsalivary gland cavitation
B0062023cellular_componentcollagen-containing extracellular matrix
B0070062cellular_componentextracellular exosome
B0071314biological_processcellular response to cocaine
B0120294molecular_functionpeptide serotonyltransferase activity
B0120295molecular_functionhistone serotonyltransferase activity
B0120296molecular_functionpeptide dopaminyltransferase activity
B0120297molecular_functionhistone dopaminyltransferase activity
B0120298molecular_functionpeptide noradrenalinyltransferase activity
B0120299molecular_functionpeptide histaminyltransferase activity
B1903351biological_processcellular response to dopamine
B1904015biological_processcellular response to serotonin
B2000425biological_processregulation of apoptotic cell clearance
C0000166molecular_functionnucleotide binding
C0000785cellular_componentchromatin
C0000786cellular_componentnucleosome
C0003810molecular_functionprotein-glutamine gamma-glutamyltransferase activity
C0005509molecular_functioncalcium ion binding
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005576cellular_componentextracellular region
C0005634cellular_componentnucleus
C0005694cellular_componentchromosome
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005925cellular_componentfocal adhesion
C0006338biological_processchromatin remodeling
C0006508biological_processproteolysis
C0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
C0008233molecular_functionpeptidase activity
C0010467biological_processgene expression
C0014046biological_processdopamine secretion
C0016020cellular_componentmembrane
C0016740molecular_functiontransferase activity
C0016746molecular_functionacyltransferase activity
C0016787molecular_functionhydrolase activity
C0018149biological_processpeptide cross-linking
C0018277biological_processprotein deamination
C0031012cellular_componentextracellular matrix
C0032471biological_processnegative regulation of endoplasmic reticulum calcium ion concentration
C0042981biological_processregulation of apoptotic process
C0043065biological_processpositive regulation of apoptotic process
C0043277biological_processapoptotic cell clearance
C0043547biological_processpositive regulation of GTPase activity
C0045785biological_processpositive regulation of cell adhesion
C0046872molecular_functionmetal ion binding
C0048471cellular_componentperinuclear region of cytoplasm
C0050568molecular_functionprotein-glutamine glutaminase activity
C0050769biological_processpositive regulation of neurogenesis
C0051057biological_processpositive regulation of small GTPase mediated signal transduction
C0051561biological_processpositive regulation of mitochondrial calcium ion concentration
C0060348biological_processbone development
C0060445biological_processbranching involved in salivary gland morphogenesis
C0060662biological_processsalivary gland cavitation
C0062023cellular_componentcollagen-containing extracellular matrix
C0070062cellular_componentextracellular exosome
C0071314biological_processcellular response to cocaine
C0120294molecular_functionpeptide serotonyltransferase activity
C0120295molecular_functionhistone serotonyltransferase activity
C0120296molecular_functionpeptide dopaminyltransferase activity
C0120297molecular_functionhistone dopaminyltransferase activity
C0120298molecular_functionpeptide noradrenalinyltransferase activity
C0120299molecular_functionpeptide histaminyltransferase activity
C1903351biological_processcellular response to dopamine
C1904015biological_processcellular response to serotonin
C2000425biological_processregulation of apoptotic cell clearance
D0000166molecular_functionnucleotide binding
D0000785cellular_componentchromatin
D0000786cellular_componentnucleosome
D0003810molecular_functionprotein-glutamine gamma-glutamyltransferase activity
D0005509molecular_functioncalcium ion binding
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005576cellular_componentextracellular region
D0005634cellular_componentnucleus
D0005694cellular_componentchromosome
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005783cellular_componentendoplasmic reticulum
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005925cellular_componentfocal adhesion
D0006338biological_processchromatin remodeling
D0006508biological_processproteolysis
D0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
D0008233molecular_functionpeptidase activity
D0010467biological_processgene expression
D0014046biological_processdopamine secretion
D0016020cellular_componentmembrane
D0016740molecular_functiontransferase activity
D0016746molecular_functionacyltransferase activity
D0016787molecular_functionhydrolase activity
D0018149biological_processpeptide cross-linking
D0018277biological_processprotein deamination
D0031012cellular_componentextracellular matrix
D0032471biological_processnegative regulation of endoplasmic reticulum calcium ion concentration
D0042981biological_processregulation of apoptotic process
D0043065biological_processpositive regulation of apoptotic process
D0043277biological_processapoptotic cell clearance
D0043547biological_processpositive regulation of GTPase activity
D0045785biological_processpositive regulation of cell adhesion
D0046872molecular_functionmetal ion binding
D0048471cellular_componentperinuclear region of cytoplasm
D0050568molecular_functionprotein-glutamine glutaminase activity
D0050769biological_processpositive regulation of neurogenesis
D0051057biological_processpositive regulation of small GTPase mediated signal transduction
D0051561biological_processpositive regulation of mitochondrial calcium ion concentration
D0060348biological_processbone development
D0060445biological_processbranching involved in salivary gland morphogenesis
D0060662biological_processsalivary gland cavitation
D0062023cellular_componentcollagen-containing extracellular matrix
D0070062cellular_componentextracellular exosome
D0071314biological_processcellular response to cocaine
D0120294molecular_functionpeptide serotonyltransferase activity
D0120295molecular_functionhistone serotonyltransferase activity
D0120296molecular_functionpeptide dopaminyltransferase activity
D0120297molecular_functionhistone dopaminyltransferase activity
D0120298molecular_functionpeptide noradrenalinyltransferase activity
D0120299molecular_functionpeptide histaminyltransferase activity
D1903351biological_processcellular response to dopamine
D1904015biological_processcellular response to serotonin
D2000425biological_processregulation of apoptotic cell clearance
E0000166molecular_functionnucleotide binding
E0000785cellular_componentchromatin
E0000786cellular_componentnucleosome
E0003810molecular_functionprotein-glutamine gamma-glutamyltransferase activity
E0005509molecular_functioncalcium ion binding
E0005515molecular_functionprotein binding
E0005525molecular_functionGTP binding
E0005576cellular_componentextracellular region
E0005634cellular_componentnucleus
E0005694cellular_componentchromosome
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005783cellular_componentendoplasmic reticulum
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0005925cellular_componentfocal adhesion
E0006338biological_processchromatin remodeling
E0006508biological_processproteolysis
E0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
E0008233molecular_functionpeptidase activity
E0010467biological_processgene expression
E0014046biological_processdopamine secretion
E0016020cellular_componentmembrane
E0016740molecular_functiontransferase activity
E0016746molecular_functionacyltransferase activity
E0016787molecular_functionhydrolase activity
E0018149biological_processpeptide cross-linking
E0018277biological_processprotein deamination
E0031012cellular_componentextracellular matrix
E0032471biological_processnegative regulation of endoplasmic reticulum calcium ion concentration
E0042981biological_processregulation of apoptotic process
E0043065biological_processpositive regulation of apoptotic process
E0043277biological_processapoptotic cell clearance
E0043547biological_processpositive regulation of GTPase activity
E0045785biological_processpositive regulation of cell adhesion
E0046872molecular_functionmetal ion binding
E0048471cellular_componentperinuclear region of cytoplasm
E0050568molecular_functionprotein-glutamine glutaminase activity
E0050769biological_processpositive regulation of neurogenesis
E0051057biological_processpositive regulation of small GTPase mediated signal transduction
E0051561biological_processpositive regulation of mitochondrial calcium ion concentration
E0060348biological_processbone development
E0060445biological_processbranching involved in salivary gland morphogenesis
E0060662biological_processsalivary gland cavitation
E0062023cellular_componentcollagen-containing extracellular matrix
E0070062cellular_componentextracellular exosome
E0071314biological_processcellular response to cocaine
E0120294molecular_functionpeptide serotonyltransferase activity
E0120295molecular_functionhistone serotonyltransferase activity
E0120296molecular_functionpeptide dopaminyltransferase activity
E0120297molecular_functionhistone dopaminyltransferase activity
E0120298molecular_functionpeptide noradrenalinyltransferase activity
E0120299molecular_functionpeptide histaminyltransferase activity
E1903351biological_processcellular response to dopamine
E1904015biological_processcellular response to serotonin
E2000425biological_processregulation of apoptotic cell clearance
F0000166molecular_functionnucleotide binding
F0000785cellular_componentchromatin
F0000786cellular_componentnucleosome
F0003810molecular_functionprotein-glutamine gamma-glutamyltransferase activity
F0005509molecular_functioncalcium ion binding
F0005515molecular_functionprotein binding
F0005525molecular_functionGTP binding
F0005576cellular_componentextracellular region
F0005634cellular_componentnucleus
F0005694cellular_componentchromosome
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005783cellular_componentendoplasmic reticulum
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005925cellular_componentfocal adhesion
F0006338biological_processchromatin remodeling
F0006508biological_processproteolysis
F0007200biological_processphospholipase C-activating G protein-coupled receptor signaling pathway
F0008233molecular_functionpeptidase activity
F0010467biological_processgene expression
F0014046biological_processdopamine secretion
F0016020cellular_componentmembrane
F0016740molecular_functiontransferase activity
F0016746molecular_functionacyltransferase activity
F0016787molecular_functionhydrolase activity
F0018149biological_processpeptide cross-linking
F0018277biological_processprotein deamination
F0031012cellular_componentextracellular matrix
F0032471biological_processnegative regulation of endoplasmic reticulum calcium ion concentration
F0042981biological_processregulation of apoptotic process
F0043065biological_processpositive regulation of apoptotic process
F0043277biological_processapoptotic cell clearance
F0043547biological_processpositive regulation of GTPase activity
F0045785biological_processpositive regulation of cell adhesion
F0046872molecular_functionmetal ion binding
F0048471cellular_componentperinuclear region of cytoplasm
F0050568molecular_functionprotein-glutamine glutaminase activity
F0050769biological_processpositive regulation of neurogenesis
F0051057biological_processpositive regulation of small GTPase mediated signal transduction
F0051561biological_processpositive regulation of mitochondrial calcium ion concentration
F0060348biological_processbone development
F0060445biological_processbranching involved in salivary gland morphogenesis
F0060662biological_processsalivary gland cavitation
F0062023cellular_componentcollagen-containing extracellular matrix
F0070062cellular_componentextracellular exosome
F0071314biological_processcellular response to cocaine
F0120294molecular_functionpeptide serotonyltransferase activity
F0120295molecular_functionhistone serotonyltransferase activity
F0120296molecular_functionpeptide dopaminyltransferase activity
F0120297molecular_functionhistone dopaminyltransferase activity
F0120298molecular_functionpeptide noradrenalinyltransferase activity
F0120299molecular_functionpeptide histaminyltransferase activity
F1903351biological_processcellular response to dopamine
F1904015biological_processcellular response to serotonin
F2000425biological_processregulation of apoptotic cell clearance
Functional Information from PDB Data
site_idAC1
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GDP A 700
ChainResidue
APHE174
ALEU582
ATYR583
AARG476
AARG478
AVAL479
AGLY480
AGLN481
ASER482
AMET483
AARG580

site_idAC2
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GDP B 701
ChainResidue
BPHE174
BARG476
BARG478
BVAL479
BGLY480
BGLN481
BSER482
BMET483
BARG580
BLEU582
BTYR583

site_idAC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE GDP C 702
ChainResidue
CPHE174
CARG476
CARG478
CVAL479
CGLY480
CGLN481
CSER482
CMET483
CARG580
CLEU582
CTYR583
CHOH751

site_idAC4
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GDP D 703
ChainResidue
DPHE174
DARG476
DARG478
DVAL479
DGLY480
DGLN481
DSER482
DMET483
DARG580
DLEU582
DTYR583

site_idAC5
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GDP E 704
ChainResidue
EPHE174
EARG476
EARG478
EVAL479
EGLY480
EGLN481
ESER482
EMET483
EARG580
ELEU582
ETYR583

site_idAC6
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GDP F 705
ChainResidue
FPHE174
FARG476
FARG478
FVAL479
FGLY480
FGLN481
FSER482
FMET483
FARG580
FLEU582
FTYR583

Functional Information from PROSITE/UniProt
site_idPS00547
Number of Residues18
DetailsTRANSGLUTAMINASES Transglutaminases active site. GQCWVfAAVacTvLRCLG
ChainResidueDetails
AGLY275-GLY292

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10024, ECO:0000305|PubMed:7649299, ECO:0000305|PubMed:8943303
ChainResidueDetails
ACYS277
BCYS277
CCYS277
DCYS277
ECYS277
FCYS277

site_idSWS_FT_FI2
Number of Residues12
DetailsACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU10024
ChainResidueDetails
AHIS335
EASP358
FHIS335
FASP358
AASP358
BHIS335
BASP358
CHIS335
CASP358
DHIS335
DASP358
EHIS335

site_idSWS_FT_FI3
Number of Residues24
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P00488
ChainResidueDetails
AASN398
CASP400
CGLU447
CGLU452
DASN398
DASP400
DGLU447
DGLU452
EASN398
EASP400
EGLU447
AASP400
EGLU452
FASN398
FASP400
FGLU447
FGLU452
AGLU447
AGLU452
BASN398
BASP400
BGLU447
BGLU452
CASN398

site_idSWS_FT_FI4
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:31991788
ChainResidueDetails
AGLU437
EGLU539
FGLU437
FGLU539
AGLU539
BGLU437
BGLU539
CGLU437
CGLU539
DGLU437
DGLU539
EGLU437

site_idSWS_FT_FI5
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:25192068, ECO:0000269|PubMed:30321187, ECO:0000269|PubMed:31991788, ECO:0000305|PubMed:11867708, ECO:0000305|PubMed:20450932, ECO:0007744|PDB:1KV3, ECO:0007744|PDB:3LY6, ECO:0007744|PDB:4PYG, ECO:0007744|PDB:6A8P, ECO:0007744|PDB:6KZB
ChainResidueDetails
AARG476
EARG580
FARG476
FARG580
AARG580
BARG476
BARG580
CARG476
CARG580
DARG476
DARG580
EARG476

site_idSWS_FT_FI6
Number of Residues6
DetailsSITE: Important for catalytic activity => ECO:0000250|UniProtKB:P52181
ChainResidueDetails
ATYR516
BTYR516
CTYR516
DTYR516
ETYR516
FTYR516

site_idSWS_FT_FI7
Number of Residues6
DetailsMOD_RES: N-acetylalanine => ECO:0000269|Ref.10, ECO:0007744|PubMed:22814378
ChainResidueDetails
AALA2
BALA2
CALA2
DALA2
EALA2
FALA2

site_idSWS_FT_FI8
Number of Residues6
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER60
BSER60
CSER60
DSER60
ESER60
FSER60

site_idSWS_FT_FI9
Number of Residues6
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P21981
ChainResidueDetails
ALYS468
BLYS468
CLYS468
DLYS468
ELYS468
FLYS468

site_idSWS_FT_FI10
Number of Residues12
DetailsCROSSLNK: Isoglutamyl lysine isopeptide (Gln-Lys) (interchain with K-?) => ECO:0000250|UniProtKB:P08587
ChainResidueDetails
AGLN633
FGLN633
BGLN633
CGLN633
DGLN633
EGLN633

218853

건을2024-04-24부터공개중

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