1INJ

CRYSTAL STRUCTURE OF THE APO FORM OF 4-DIPHOSPHOCYTIDYL-2-C-METHYLERYTHRITOL (CDP-ME) SYNTHETASE (YGBP) INVOLVED IN MEVALONATE INDEPENDENT ISOPRENOID BIOSYNTHESIS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000287	molecular_function	magnesium ion binding
A	0003824	molecular_function	catalytic activity
A	0005829	cellular_component	cytosol
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016114	biological_process	terpenoid biosynthetic process
A	0016740	molecular_function	transferase activity
A	0016779	molecular_function	nucleotidyltransferase activity
A	0019288	biological_process	isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway
A	0042802	molecular_function	identical protein binding
A	0050518	molecular_function	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
A	0070567	molecular_function	cytidylyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1001

Chain	Residue
A	LEU46
A	GLU172
A	HOH1004
A	HOH1122
A	HOH1124
A	HOH1128

---

Functional Information from PROSITE/UniProt

site_id	PS01295
Number of Residues	8
Details	ISPD 4-diphosphocytidyl-2C-methyl-D-erythritol synthase signature. VLVHDAAR

Chain	Residue	Details
A	VAL102-ARG109

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	SITE: Transition state stabilizer => ECO:0000269|PubMed:11427897

Chain	Residue	Details
A	ARG20
A	LYS27

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	SITE: Positions MEP for the nucleophilic attack => ECO:0000269|PubMed:11427897

Chain	Residue	Details
A	ARG157
A	LYS213

---