1HOV

SOLUTION STRUCTURE OF A CATALYTIC DOMAIN OF MMP-2 COMPLEXED WITH SC-74020

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
A	0008270	molecular_function	zinc ion binding
A	0031012	cellular_component	extracellular matrix

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 165

Chain	Residue
A	HIS70
A	ASP72
A	HIS85
A	HIS98

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 166

Chain	Residue
A	HIS120
A	HIS124
A	HIS130
A	I52800

---

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CA A 167

Chain	Residue
A	GLY78
A	LYS79
A	ASP80
A	LEU82
A	ASP100
A	GLU103
A	ASP77

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 168

Chain	Residue
A	ASP60
A	GLY92
A	VAL93
A	GLY94
A	GLY95
A	ASP96

---

site_id	AC5
Number of Residues	19
Details	BINDING SITE FOR RESIDUE I52 A 800

Chain	Residue
A	GLY81
A	LEU82
A	LEU83
A	ALA84
A	HIS85
A	HIS120
A	GLU121
A	HIS124
A	HIS130
A	ALA136
A	LEU137
A	ALA139
A	ILE141
A	TYR142
A	THR143
A	THR145
A	PHE148
A	ARG149
A	ZN166

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Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VAAHEFGHAM

Chain	Residue	Details
A	VAL117-MET126

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1QIB, ECO:0007744|PDB:3AYU

Chain	Residue	Details
A	ASP101
A	ASP26

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1EAK, ECO:0007744|PDB:3AYU

Chain	Residue	Details
A	ASP60
A	GLY92

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:10356396, ECO:0000269|PubMed:12032297, ECO:0000269|PubMed:21813640, ECO:0007744|PDB:1CK7, ECO:0007744|PDB:1EAK, ECO:0007744|PDB:1GXD, ECO:0007744|PDB:1QIB, ECO:0007744|PDB:3AYU

Chain	Residue	Details
A	HIS98
A	HIS70
A	ASP72
A	HIS85

---

site_id	SWS_FT_FI4
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:21813640, ECO:0007744|PDB:3AYU

Chain	Residue	Details
A	ASP96
A	ASP100
A	GLU103
A	ASP77
A	GLY78
A	GLY94

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues
Details	M-CSA 906

Chain

Residue

Details

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