1HCQ
THE CRYSTAL STRUCTURE OF THE ESTROGEN RECEPTOR DNA-BINDING DOMAIN BOUND TO DNA: HOW RECEPTORS DISCRIMINATE BETWEEN THEIR RESPONSE ELEMENTS
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0008270 | molecular_function | zinc ion binding |
| A | 0043565 | molecular_function | sequence-specific DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0008270 | molecular_function | zinc ion binding |
| B | 0043565 | molecular_function | sequence-specific DNA binding |
| E | 0003700 | molecular_function | DNA-binding transcription factor activity |
| E | 0006355 | biological_process | regulation of DNA-templated transcription |
| E | 0008270 | molecular_function | zinc ion binding |
| E | 0043565 | molecular_function | sequence-specific DNA binding |
| F | 0003700 | molecular_function | DNA-binding transcription factor activity |
| F | 0006355 | biological_process | regulation of DNA-templated transcription |
| F | 0008270 | molecular_function | zinc ion binding |
| F | 0043565 | molecular_function | sequence-specific DNA binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 598 |
| Chain | Residue |
| A | CYS7 |
| A | CYS10 |
| A | CYS24 |
| A | CYS27 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 599 |
| Chain | Residue |
| A | CYS43 |
| A | CYS49 |
| A | CYS59 |
| A | CYS62 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 598 |
| Chain | Residue |
| B | CYS10 |
| B | CYS24 |
| B | CYS27 |
| B | ARG56 |
| B | CYS7 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 599 |
| Chain | Residue |
| B | CYS43 |
| B | CYS49 |
| B | CYS59 |
| B | CYS62 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 598 |
| Chain | Residue |
| E | CYS7 |
| E | CYS10 |
| E | CYS24 |
| E | CYS27 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 599 |
| Chain | Residue |
| E | CYS43 |
| E | CYS49 |
| E | CYS59 |
| E | CYS62 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 598 |
| Chain | Residue |
| F | CYS7 |
| F | CYS10 |
| F | CYS24 |
| F | CYS27 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN F 599 |
| Chain | Residue |
| F | CYS43 |
| F | PRO44 |
| F | CYS49 |
| F | CYS59 |
| F | CYS62 |
Functional Information from PROSITE/UniProt
| site_id | PS00031 |
| Number of Residues | 27 |
| Details | NUCLEAR_REC_DBD_1 Nuclear hormones receptors DNA-binding region signature. CavCn.Dyasgy.HYgvwsCegCkaFFkR |
| Chain | Residue | Details |
| A | CYS7-ARG33 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 260 |
| Details | DNA_BIND: Nuclear receptor => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | CYS7-MET72 | |
| B | CYS7-MET72 | |
| E | CYS7-MET72 | |
| F | CYS7-MET72 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 176 |
| Details | ZN_FING: NR C4-type => ECO:0000255|PROSITE-ProRule:PRU00407 |
| Chain | Residue | Details |
| A | CYS7-CYS27 | |
| A | CYS43-CYS67 | |
| B | CYS7-CYS27 | |
| B | CYS43-CYS67 | |
| E | CYS7-CYS27 | |
| E | CYS43-CYS67 | |
| F | CYS7-CYS27 | |
| F | CYS43-CYS67 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | MOD_RES: Asymmetric dimethylarginine; by PRMT1 => ECO:0000269|PubMed:18657504, ECO:0000269|PubMed:24498420 |
| Chain | Residue | Details |
| A | ARG82 | |
| B | ARG82 | |
| E | ARG82 | |
| F | ARG82 |
