1H15

X-ray crystal structure of HLA-DRA1*0101/DRB5*0101 complexed with a peptide from Epstein Barr Virus DNA polymerase

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Functional Information from GO Data

ChainGOidnamespacecontents
C0042025cellular_componenthost cell nucleus
C0003677molecular_functionDNA binding
C0003887molecular_functionDNA-directed DNA polymerase activity
C0004527molecular_functionexonuclease activity
C0000166molecular_functionnucleotide binding
C0039686biological_processbidirectional double-stranded viral DNA replication
C0006260biological_processDNA replication
F0042025cellular_componenthost cell nucleus
F0003677molecular_functionDNA binding
F0003887molecular_functionDNA-directed DNA polymerase activity
F0004527molecular_functionexonuclease activity
F0000166molecular_functionnucleotide binding
F0039686biological_processbidirectional double-stranded viral DNA replication
F0006260biological_processDNA replication
A0009986cellular_componentcell surface
A0030669cellular_componentclathrin-coated endocytic vesicle membrane
A0030666cellular_componentendocytic vesicle membrane
A0012507cellular_componentER to Golgi transport vesicle membrane
A0070062cellular_componentextracellular exosome
A0000139cellular_componentGolgi membrane
A0071556cellular_componentintegral component of lumenal side of endoplasmic reticulum membrane
A0005887cellular_componentintegral component of plasma membrane
A0031902cellular_componentlate endosome membrane
A0005765cellular_componentlysosomal membrane
A0005764cellular_componentlysosome
A0042613cellular_componentMHC class II protein complex
A0005886cellular_componentplasma membrane
A0032588cellular_componenttrans-Golgi network membrane
A0030658cellular_componenttransport vesicle membrane
A0023026molecular_functionMHC class II protein complex binding
A0032395molecular_functionMHC class II receptor activity
A0042605molecular_functionpeptide antigen binding
A0030247molecular_functionpolysaccharide binding
A0002250biological_processadaptive immune response
A0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
A0002504biological_processantigen processing and presentation of peptide or polysaccharide antigen via MHC class II
A0050890biological_processcognition
A0006955biological_processimmune response
A0060333biological_processinterferon-gamma-mediated signaling pathway
A0002503biological_processpeptide antigen assembly with MHC class II protein complex
A0050852biological_processT cell receptor signaling pathway
A0016032biological_processviral process
D0009986cellular_componentcell surface
D0030669cellular_componentclathrin-coated endocytic vesicle membrane
D0030666cellular_componentendocytic vesicle membrane
D0012507cellular_componentER to Golgi transport vesicle membrane
D0070062cellular_componentextracellular exosome
D0000139cellular_componentGolgi membrane
D0071556cellular_componentintegral component of lumenal side of endoplasmic reticulum membrane
D0005887cellular_componentintegral component of plasma membrane
D0031902cellular_componentlate endosome membrane
D0005765cellular_componentlysosomal membrane
D0005764cellular_componentlysosome
D0042613cellular_componentMHC class II protein complex
D0005886cellular_componentplasma membrane
D0032588cellular_componenttrans-Golgi network membrane
D0030658cellular_componenttransport vesicle membrane
D0023026molecular_functionMHC class II protein complex binding
D0032395molecular_functionMHC class II receptor activity
D0042605molecular_functionpeptide antigen binding
D0030247molecular_functionpolysaccharide binding
D0002250biological_processadaptive immune response
D0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
D0002504biological_processantigen processing and presentation of peptide or polysaccharide antigen via MHC class II
D0050890biological_processcognition
D0006955biological_processimmune response
D0060333biological_processinterferon-gamma-mediated signaling pathway
D0002503biological_processpeptide antigen assembly with MHC class II protein complex
D0050852biological_processT cell receptor signaling pathway
D0016032biological_processviral process
B0030669cellular_componentclathrin-coated endocytic vesicle membrane
B0030666cellular_componentendocytic vesicle membrane
B0012507cellular_componentER to Golgi transport vesicle membrane
B0070062cellular_componentextracellular exosome
B0000139cellular_componentGolgi membrane
B0071556cellular_componentintegral component of lumenal side of endoplasmic reticulum membrane
B0031902cellular_componentlate endosome membrane
B0005765cellular_componentlysosomal membrane
B0042613cellular_componentMHC class II protein complex
B0005886cellular_componentplasma membrane
B0032588cellular_componenttrans-Golgi network membrane
B0030658cellular_componenttransport vesicle membrane
B0042605molecular_functionpeptide antigen binding
B0002250biological_processadaptive immune response
B0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
B0060333biological_processinterferon-gamma-mediated signaling pathway
B0050852biological_processT cell receptor signaling pathway
E0030669cellular_componentclathrin-coated endocytic vesicle membrane
E0030666cellular_componentendocytic vesicle membrane
E0012507cellular_componentER to Golgi transport vesicle membrane
E0070062cellular_componentextracellular exosome
E0000139cellular_componentGolgi membrane
E0071556cellular_componentintegral component of lumenal side of endoplasmic reticulum membrane
E0031902cellular_componentlate endosome membrane
E0005765cellular_componentlysosomal membrane
E0042613cellular_componentMHC class II protein complex
E0005886cellular_componentplasma membrane
E0032588cellular_componenttrans-Golgi network membrane
E0030658cellular_componenttransport vesicle membrane
E0042605molecular_functionpeptide antigen binding
E0002250biological_processadaptive immune response
E0019886biological_processantigen processing and presentation of exogenous peptide antigen via MHC class II
E0060333biological_processinterferon-gamma-mediated signaling pathway
E0050852biological_processT cell receptor signaling pathway
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Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC11BINDING SITE FOR CHAIN A OF SUGAR BOUND TO ASN A 78 RESIDUES 1185 TO 1185
ChainResidue
AASN78

AC24BINDING SITE FOR CHAIN A OF SUGAR BOUND TO ASN A 118 RESIDUES 1183 TO 1184
ChainResidue
AASN118
AGLU166
ATRP168
BASP2

AC31BINDING SITE FOR CHAIN D OF SUGAR BOUND TO ASN D 78 RESIDUES 1184 TO 1184
ChainResidue
DASN78

AC43BINDING SITE FOR MONO-SACCHARIDE NAG D1183 BOUND TO ASN D 118
ChainResidue
DVAL117
DASN118
DGLU166

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Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
NAG_1h15_A_11851N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
AASN78NAG: N-ACETYL-D-GLUCOSAMINE

NAG_1h15_A_11835N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
AASN118NAG: N-ACETYL-D-GLUCOSAMINE
AGLU166-TRP168NAG: N-ACETYL-D-GLUCOSAMINE
BASP2NAG: N-ACETYL-D-GLUCOSAMINE

NAG_1h15_A_11842N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
ATRP168NAG: N-ACETYL-D-GLUCOSAMINE
BASP2NAG: N-ACETYL-D-GLUCOSAMINE

NAG_1h15_D_11841N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
DASN78NAG: N-ACETYL-D-GLUCOSAMINE

NAG_1h15_D_11835N-ACETYL-D-GLUCOSAMINE binding site
ChainResidueligand
DVAL116-ASN118NAG: N-ACETYL-D-GLUCOSAMINE
DGLU166NAG: N-ACETYL-D-GLUCOSAMINE
DTRP168NAG: N-ACETYL-D-GLUCOSAMINE

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Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
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Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI123Helical; (Potential).
ChainResidueDetails
ANA*

SWS_FT_FI223Helical; (Potential).
ChainResidueDetails
DNA*

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Catalytic Information from CSA

site_idNumber of ResiduesDetails