1F3M

CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004674	molecular_function	protein serine/threonine kinase activity
B	0004674	molecular_function	protein serine/threonine kinase activity
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
D	0004672	molecular_function	protein kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 601

Chain	Residue
A	ASN132

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD C 602

Chain	Residue
C	ASN468
C	LEU470
C	IOD616

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site_id	AC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD D 603

Chain	Residue
D	HOH631

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD D 604

Chain	Residue
D	PRO325
D	IOD628

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site_id	AC5
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 605

Chain	Residue
C	HOH653

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 607

Chain	Residue
A	LYS114

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site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD B 608

Chain	Residue
A	GLN102
A	HOH667
B	GLY98

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site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD C 609

Chain	Residue
C	HOH628

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site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD C 610

Chain	Residue
C	ASN466
D	LYS268

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site_id	BC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD C 611

Chain	Residue
C	GLY364

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site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD C 613

Chain	Residue
C	PRO325

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site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD A 614

Chain	Residue
A	LYS119
B	IOD615
B	HOH652

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site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE IOD B 615

Chain	Residue
A	ASN120
A	IOD614
B	LYS119
C	HOH695

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site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD C 616

Chain	Residue
A	HOH640
C	IOD602
C	HOH629

---

site_id	BC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B 617

Chain	Residue
B	HOH660

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site_id	BC7
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD D 619

Chain	Residue
D	MET399

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site_id	BC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD A 620

Chain	Residue
A	LYS134

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site_id	BC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD D 621

Chain	Residue
D	GLY364

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site_id	CC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD D 622

Chain	Residue
D	ASP265

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site_id	CC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD C 623

Chain	Residue
C	LYS444

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site_id	CC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE IOD B 624

Chain	Residue
B	HOH631

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site_id	CC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD D 625

Chain	Residue
C	LEU347
D	ASP400

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site_id	CC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IOD C 627

Chain	Residue
C	GLU514
C	HOH701

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site_id	CC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IOD D 628

Chain	Residue
D	LYS323
D	ASN324
D	IOD604

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Functional Information from PROSITE/UniProt

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. ViHrDIKsdNILL

Chain	Residue	Details
C	VAL385-LEU397

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Proton acceptor => ECO:0000269|PubMed:22153498

Chain	Residue	Details
C	ASP389
D	ASP389

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site_id	SWS_FT_FI2
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:22153498

Chain	Residue	Details
C	GLU345
D	ILE276
D	ARG299
D	GLU345
C	ILE276
C	ARG299

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphotyrosine; by JAK2 => ECO:0000269|PubMed:17726028, ECO:0000269|PubMed:17989089

Chain	Residue	Details
B	TYR131
B	TYR142
C	TYR285
D	TYR285

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine; by autocatalysis, BRSK2 and PDPK1 => ECO:0000269|PubMed:10551809, ECO:0000269|PubMed:10995762, ECO:0000269|PubMed:22153498, ECO:0000269|PubMed:22669945

Chain	Residue	Details
C	THR423
D	THR423

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21406692

Chain	Residue	Details
A	SER149
B	SER149

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