1EVG
CRYSTAL STRUCTURE ANALYSIS OF CYS167 MUTANT OF ESCHERICHIA COLI WITH UNMODIFIED CATALYTIC CYSTEINE
GO（遺伝子オントロジー）由来の情報
| 鎖名 | GO（遺伝子オントロジー）id | 名前空間 | 内容 |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0003723 | molecular_function | RNA binding |
| A | 0004799 | molecular_function | thymidylate synthase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006231 | biological_process | dTMP biosynthetic process |
| A | 0006235 | biological_process | dTTP biosynthetic process |
| A | 0006417 | biological_process | regulation of translation |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0009165 | biological_process | nucleotide biosynthetic process |
| A | 0009314 | biological_process | response to radiation |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016741 | molecular_function | transferase activity, transferring one-carbon groups |
| A | 0032259 | biological_process | methylation |
| A | 0042803 | molecular_function | protein homodimerization activity |
PDBデータベースに由来する情報
| site_id | AC1 |
| 残基数 | 5 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A 320 |
| 鎖名 | 残基 |
| A | ARG21 |
| A | ARG126 |
| A | ARG166 |
| A | HOH406 |
| A | HOH407 |
| site_id | AC2 |
| 残基数 | 4 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A 321 |
| 鎖名 | 残基 |
| A | ARG49 |
| A | PRO256 |
| A | GLY257 |
| A | HOH352 |
| site_id | AC3 |
| 残基数 | 3 |
| 詳細 | BINDING SITE FOR RESIDUE SO4 A 322 |
| 鎖名 | 残基 |
| A | GLU223 |
| A | ARG225 |
| A | HIS255 |
UniProtにおけるモチーフ・データベースPROSITEからの機能情報
| site_id | PS00091 |
| 残基数 | 29 |
| 詳細 | THYMIDYLATE_SYNTHASE Thymidylate synthase active site. RriIvsaWNvgeldkma.....LaPCHaffQFyV |
| 鎖名 | 残基 | 詳細 |
| A | ARG126-VAL154 |
SwissProt/UniProtに記載されている蛋白質分子機能情報
| site_id | SWS_FT_FI1 |
| 残基数 | 1 |
| 詳細 | ACT_SITE: Nucleophile => ECO:0000255|HAMAP-Rule:MF_00008, ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0000269|PubMed:9416600 |
| 鎖名 | 残基 | 詳細 |
| A | CYS146 |
| site_id | SWS_FT_FI2 |
| 残基数 | 4 |
| 詳細 | BINDING: in other chain => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC |
| 鎖名 | 残基 | 詳細 |
| A | ASN177 | |
| A | HIS207 | |
| A | ARG21 | |
| A | ARG166 |
| site_id | SWS_FT_FI3 |
| 残基数 | 3 |
| 詳細 | BINDING: BINDING => ECO:0000305|PubMed:8312270, ECO:0007744|PDB:1TYS |
| 鎖名 | 残基 | 詳細 |
| A | ASP169 | |
| A | ALA263 | |
| A | HIS51 |
| site_id | SWS_FT_FI4 |
| 残基数 | 1 |
| 詳細 | BINDING: BINDING => ECO:0000269|PubMed:2223754, ECO:0000269|PubMed:8973201, ECO:0007744|PDB:1KCE, ECO:0007744|PDB:2TSC |
| 鎖名 | 残基 | 詳細 |
| A | ARG126 |
