1DVR

STRUCTURE OF A MUTANT ADENYLATE KINASE LIGATED WITH AN ATP-ANALOGUE SHOWING DOMAIN CLOSURE OVER ATP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004017	molecular_function	adenylate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006172	biological_process	ADP biosynthetic process
A	0006270	biological_process	DNA replication initiation
A	0009117	biological_process	nucleotide metabolic process
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016740	molecular_function	transferase activity
A	0016776	molecular_function	phosphotransferase activity, phosphate group as acceptor
A	0019205	molecular_function	nucleobase-containing compound kinase activity
A	0046033	biological_process	AMP metabolic process
A	0046034	biological_process	ATP metabolic process
A	0046940	biological_process	nucleoside monophosphate phosphorylation
B	0000166	molecular_function	nucleotide binding
B	0004017	molecular_function	adenylate kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006172	biological_process	ADP biosynthetic process
B	0006270	biological_process	DNA replication initiation
B	0009117	biological_process	nucleotide metabolic process
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016740	molecular_function	transferase activity
B	0016776	molecular_function	phosphotransferase activity, phosphate group as acceptor
B	0019205	molecular_function	nucleobase-containing compound kinase activity
B	0046033	biological_process	AMP metabolic process
B	0046034	biological_process	ATP metabolic process
B	0046940	biological_process	nucleoside monophosphate phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE ATF A 230

Chain	Residue
A	PRO13
A	SER141
A	TYR142
A	HIS143
A	PHE146
A	ALA202
A	GLN204
A	PRO206
A	HOH243
A	HOH249
A	HOH252
A	GLY14
A	HOH291
B	LYS55
B	GLN59
B	HOH231
A	ALA15
A	GLY16
A	LYS17
A	GLY18
A	THR19
A	ARG128
A	ARG132

---

site_id	AC2
Number of Residues	19
Details	BINDING SITE FOR RESIDUE ATF B 230

Chain	Residue
A	LYS55
A	GLN59
B	PRO13
B	GLY14
B	GLY16
B	LYS17
B	GLY18
B	THR19
B	ARG128
B	ARG132
B	SER141
B	TYR142
B	HIS143
B	PHE146
B	GLN204
B	PRO205
B	PRO206
B	HOH261
B	HOH289

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:7635152, ECO:0000269|PubMed:7670369, ECO:0000269|PubMed:8594191

Chain	Residue	Details
A	GLN204
B	GLY14
B	ARG132
B	GLN204
A	GLY14
A	ARG132

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:7635152, ECO:0000269|PubMed:7670369

Chain	Residue	Details
A	GLN97
A	ILE165
A	ARG176
B	THR35
B	ARG40
B	GLY61
B	GLY90
B	GLN97
B	ILE165
B	ARG176
A	THR35
A	ARG40
A	GLY61
A	GLY90

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:7635152, ECO:0000269|PubMed:7670369, ECO:0000269|PubMed:8594191

Chain	Residue	Details
A	SER141
B	SER141

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: N-acetylserine => ECO:0000255|HAMAP-Rule:MF_03168, ECO:0000269|PubMed:3004985

Chain	Residue	Details
A	SER1
B	SER1

---