1CYN

CYCLOPHILIN B COMPLEXED WITH [D-(CHOLINYLESTER)SER8]-CYCLOSPORIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000413	biological_process	protein peptidyl-prolyl isomerization
A	0003723	molecular_function	RNA binding
A	0003755	molecular_function	peptidyl-prolyl cis-trans isomerase activity
A	0005515	molecular_function	protein binding
A	0005518	molecular_function	collagen binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005737	cellular_component	cytoplasm
A	0005783	cellular_component	endoplasmic reticulum
A	0005788	cellular_component	endoplasmic reticulum lumen
A	0005790	cellular_component	smooth endoplasmic reticulum
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0005925	cellular_component	focal adhesion
A	0006457	biological_process	protein folding
A	0016018	molecular_function	cyclosporin A binding
A	0016020	cellular_component	membrane
A	0016853	molecular_function	isomerase activity
A	0030593	biological_process	neutrophil chemotaxis
A	0032991	cellular_component	protein-containing complex
A	0034663	cellular_component	endoplasmic reticulum chaperone complex
A	0040018	biological_process	positive regulation of multicellular organism growth
A	0042470	cellular_component	melanosome
A	0043231	cellular_component	intracellular membrane-bounded organelle
A	0044794	biological_process	positive regulation by host of viral process
A	0044829	biological_process	positive regulation by host of viral genome replication
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0050821	biological_process	protein stabilization
A	0051082	molecular_function	unfolded protein binding
A	0060348	biological_process	bone development
A	0061077	biological_process	chaperone-mediated protein folding
A	0070062	cellular_component	extracellular exosome
A	0070063	molecular_function	RNA polymerase binding
A	1901873	biological_process	regulation of post-translational protein modification

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	BINDING SITE FOR CHAIN C OF CYCLOSPORIN A

Chain	Residue
A	ARG63
A	TRP129
A	HIS134
C	HOH2001
C	HOH2002
C	HOH2004
C	HOH2006
C	HOH2007
A	PHE68
A	GLN71
A	GLY80
A	ALA109
A	ASN110
A	ALA111
A	GLN119
A	PHE121

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Functional Information from PROSITE/UniProt

site_id	PS00170
Number of Residues	18
Details	CSA_PPIASE_1 Cyclophilin-type peptidyl-prolyl cis-trans isomerase signature. YknSkFHRVIkdFMiQGG

Chain	Residue	Details
A	TYR56-GLY73

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q99KR7

Chain	Residue	Details
A	LYS60

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site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q99KR7

Chain	Residue	Details
A	LEU141

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:Q99KR7

Chain	Residue	Details
A	PRO178

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site_id	SWS_FT_FI4
Number of Residues	1
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	THR124

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