1B3O
TERNARY COMPLEX OF HUMAN TYPE-II INOSINE MONOPHOSPHATE DEHYDROGENASE WITH 6-CL-IMP AND SELENAZOLE ADENINE DINUCLEOTIDE
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0003677 | molecular_function | DNA binding |
A | 0003723 | molecular_function | RNA binding |
A | 0003824 | molecular_function | catalytic activity |
A | 0003938 | molecular_function | IMP dehydrogenase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005634 | cellular_component | nucleus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005778 | cellular_component | peroxisomal membrane |
A | 0005829 | cellular_component | cytosol |
A | 0006164 | biological_process | purine nucleotide biosynthetic process |
A | 0006177 | biological_process | GMP biosynthetic process |
A | 0006183 | biological_process | GTP biosynthetic process |
A | 0007623 | biological_process | circadian rhythm |
A | 0016020 | cellular_component | membrane |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0034774 | cellular_component | secretory granule lumen |
A | 0046651 | biological_process | lymphocyte proliferation |
A | 0046872 | molecular_function | metal ion binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0071353 | biological_process | cellular response to interleukin-4 |
A | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
B | 0000166 | molecular_function | nucleotide binding |
B | 0003677 | molecular_function | DNA binding |
B | 0003723 | molecular_function | RNA binding |
B | 0003824 | molecular_function | catalytic activity |
B | 0003938 | molecular_function | IMP dehydrogenase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005576 | cellular_component | extracellular region |
B | 0005634 | cellular_component | nucleus |
B | 0005737 | cellular_component | cytoplasm |
B | 0005778 | cellular_component | peroxisomal membrane |
B | 0005829 | cellular_component | cytosol |
B | 0006164 | biological_process | purine nucleotide biosynthetic process |
B | 0006177 | biological_process | GMP biosynthetic process |
B | 0006183 | biological_process | GTP biosynthetic process |
B | 0007623 | biological_process | circadian rhythm |
B | 0016020 | cellular_component | membrane |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0034774 | cellular_component | secretory granule lumen |
B | 0046651 | biological_process | lymphocyte proliferation |
B | 0046872 | molecular_function | metal ion binding |
B | 0070062 | cellular_component | extracellular exosome |
B | 0071353 | biological_process | cellular response to interleukin-4 |
B | 0097294 | biological_process | 'de novo' XMP biosynthetic process |
B | 1904813 | cellular_component | ficolin-1-rich granule lumen |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 9 |
Details | BINDING SITE FOR RESIDUE CPR A 631 |
Chain | Residue |
A | SER68 |
A | ARG322 |
A | SER327 |
A | ASP364 |
A | GLY366 |
A | MET385 |
A | GLY387 |
A | SER388 |
A | SAE600 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE CPR B 631 |
Chain | Residue |
B | SER68 |
B | ARG322 |
B | GLY328 |
B | SER329 |
B | CYS331 |
B | GLN334 |
B | GLU335 |
B | ASP364 |
B | GLY365 |
B | GLY366 |
B | GLY387 |
B | SER388 |
B | SAE601 |
B | HOH658 |
site_id | AC3 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE SAE A 600 |
Chain | Residue |
A | THR45 |
A | THR252 |
A | HIS253 |
A | ASP274 |
A | SER275 |
A | SER276 |
A | PHE282 |
A | ASN303 |
A | GLY324 |
A | GLN469 |
A | CPR631 |
A | HOH637 |
site_id | AC4 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE SAE B 601 |
Chain | Residue |
B | THR45 |
B | THR252 |
B | HIS253 |
B | ASP274 |
B | SER275 |
B | SER276 |
B | PHE282 |
B | ASN303 |
B | GLY324 |
B | GLN334 |
B | HIS466 |
B | GLN469 |
B | CPR631 |
B | HOH648 |
Functional Information from PROSITE/UniProt
site_id | PS00487 |
Number of Residues | 13 |
Details | IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRVGMGsGSICiT |
Chain | Residue | Details |
A | LEU321-THR333 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Thioimidate intermediate => ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|PubMed:10097070 |
Chain | Residue | Details |
A | CYS331 | |
B | CYS331 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | ACT_SITE: Proton acceptor => ECO:0000255|HAMAP-Rule:MF_03156 |
Chain | Residue | Details |
A | ARG429 | |
B | ARG429 |
site_id | SWS_FT_FI3 |
Number of Residues | 6 |
Details | BINDING: |
Chain | Residue | Details |
A | GLY387 | |
B | ASP274 | |
B | ASP364 | |
B | GLY387 | |
A | ASP274 | |
A | ASP364 |
site_id | SWS_FT_FI4 |
Number of Residues | 14 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03156 |
Chain | Residue | Details |
A | TYR411 | |
A | GLN441 | |
A | GLU500 | |
A | GLY501 | |
A | GLY502 | |
B | GLY324 | |
B | SER329 | |
B | TYR411 | |
B | GLN441 | |
B | GLU500 | |
B | GLY501 | |
B | GLY502 | |
A | GLY324 | |
A | SER329 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_03156, ECO:0000269|Ref.28 |
Chain | Residue | Details |
A | GLY326 | |
A | GLY328 | |
A | CYS331 | |
B | GLY326 | |
B | GLY328 | |
B | CYS331 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER122 | |
B | SER122 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER160 | |
B | SER160 |
site_id | SWS_FT_FI8 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455 |
Chain | Residue | Details |
A | TYR400 | |
B | TYR400 |
site_id | SWS_FT_FI9 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569 |
Chain | Residue | Details |
A | SER416 | |
B | SER416 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS511 | |
B | LYS511 |
site_id | SWS_FT_FI11 |
Number of Residues | 8 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS208 | |
A | LYS438 | |
B | LYS195 | |
B | LYS208 | |
B | LYS438 | |
A | LYS195 |