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1A4E

CATALASE A FROM SACCHAROMYCES CEREVISIAE

Functional Information from GO Data
ChainGOidnamespacecontents
A0000302biological_processresponse to reactive oxygen species
A0004096molecular_functioncatalase activity
A0004601molecular_functionperoxidase activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005759cellular_componentmitochondrial matrix
A0005777cellular_componentperoxisome
A0005782cellular_componentperoxisomal matrix
A0006979biological_processresponse to oxidative stress
A0016491molecular_functionoxidoreductase activity
A0020037molecular_functionheme binding
A0042542biological_processresponse to hydrogen peroxide
A0042744biological_processhydrogen peroxide catabolic process
A0046872molecular_functionmetal ion binding
A0098869biological_processcellular oxidant detoxification
B0000302biological_processresponse to reactive oxygen species
B0004096molecular_functioncatalase activity
B0004601molecular_functionperoxidase activity
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005759cellular_componentmitochondrial matrix
B0005777cellular_componentperoxisome
B0005782cellular_componentperoxisomal matrix
B0006979biological_processresponse to oxidative stress
B0016491molecular_functionoxidoreductase activity
B0020037molecular_functionheme binding
B0042542biological_processresponse to hydrogen peroxide
B0042744biological_processhydrogen peroxide catabolic process
B0046872molecular_functionmetal ion binding
B0098869biological_processcellular oxidant detoxification
C0000302biological_processresponse to reactive oxygen species
C0004096molecular_functioncatalase activity
C0004601molecular_functionperoxidase activity
C0005515molecular_functionprotein binding
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005759cellular_componentmitochondrial matrix
C0005777cellular_componentperoxisome
C0005782cellular_componentperoxisomal matrix
C0006979biological_processresponse to oxidative stress
C0016491molecular_functionoxidoreductase activity
C0020037molecular_functionheme binding
C0042542biological_processresponse to hydrogen peroxide
C0042744biological_processhydrogen peroxide catabolic process
C0046872molecular_functionmetal ion binding
C0098869biological_processcellular oxidant detoxification
D0000302biological_processresponse to reactive oxygen species
D0004096molecular_functioncatalase activity
D0004601molecular_functionperoxidase activity
D0005515molecular_functionprotein binding
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005759cellular_componentmitochondrial matrix
D0005777cellular_componentperoxisome
D0005782cellular_componentperoxisomal matrix
D0006979biological_processresponse to oxidative stress
D0016491molecular_functionoxidoreductase activity
D0020037molecular_functionheme binding
D0042542biological_processresponse to hydrogen peroxide
D0042744biological_processhydrogen peroxide catabolic process
D0046872molecular_functionmetal ion binding
D0098869biological_processcellular oxidant detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE AZI A 504
ChainResidue
AHIS70
AASN143
APHE148
APHE156
AHEM503

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE AZI B 504
ChainResidue
BPHE156
BHEM503
BPRO69
BHIS70
BASN143
BPHE148

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE AZI C 504
ChainResidue
CPRO69
CHIS70
CASN143
CPHE148
CPHE156
CHEM503

site_idAC4
Number of Residues6
DetailsBINDING SITE FOR RESIDUE AZI D 504
ChainResidue
DPRO69
DHIS70
DASN143
DPHE148
DPHE156
DHEM503

site_idAC5
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 A 1
ChainResidue
AARG61
BARG360
BTYR361
BHOH608
CARG61
DARG360
DTYR361
DHOH601

site_idAC6
Number of Residues8
DetailsBINDING SITE FOR RESIDUE SO4 D 2
ChainResidue
AARG360
ATYR361
AHOH604
BARG61
CARG360
CTYR361
CHOH606
DARG61

site_idAC7
Number of Residues24
DetailsBINDING SITE FOR RESIDUE HEM A 503
ChainResidue
AARG67
AASN68
APRO69
AHIS70
AARG107
AGLY126
AVAL141
ATYR142
AASN143
APHE156
ASER213
APHE331
AVAL347
AARG351
ASER354
ATYR355
AALA358
AHIS359
AARG362
AAZI504
AHOH506
AHOH509
AHOH514
DASN60

site_idAC8
Number of Residues23
DetailsBINDING SITE FOR RESIDUE HEM B 503
ChainResidue
BARG67
BASN68
BHIS70
BARG107
BGLY126
BVAL141
BTYR142
BASN143
BPHE156
BSER213
BHIS215
BPHE331
BVAL347
BARG351
BSER354
BTYR355
BHIS359
BARG362
BAZI504
BHOH511
BHOH515
BHOH523
CASN60

site_idAC9
Number of Residues24
DetailsBINDING SITE FOR RESIDUE HEM C 503
ChainResidue
CVAL347
CARG351
CSER354
CTYR355
CALA358
CHIS359
CARG362
CAZI504
CHOH510
CHOH515
CHOH521
BASN60
CARG67
CASN68
CHIS70
CARG107
CGLY126
CVAL141
CTYR142
CASN143
CPHE148
CPHE156
CSER213
CPHE331

site_idBC1
Number of Residues24
DetailsBINDING SITE FOR RESIDUE HEM D 503
ChainResidue
AASN60
DARG67
DASN68
DHIS70
DARG107
DGLY126
DVAL141
DTYR142
DASN143
DPHE148
DPHE156
DSER213
DPHE331
DVAL347
DARG351
DSER354
DTYR355
DALA358
DHIS359
DARG362
DAZI504
DHOH517
DHOH521
DHOH526

Functional Information from PROSITE/UniProt
site_idPS00437
Number of Residues9
DetailsCATALASE_1 Catalase proximal heme-ligand signature. RLFSYaDAH
ChainResidueDetails
AARG351-HIS359

site_idPS00438
Number of Residues17
DetailsCATALASE_2 Catalase proximal active site signature. FnRenipQRnpHahGSG
ChainResidueDetails
APHE59-GLY75

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsACT_SITE: ACT_SITE => ECO:0000269|PubMed:9931255
ChainResidueDetails
AHIS70
DHIS70
DASN143
AASN143
BHIS70
BASN143
CHIS70
CASN143

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: axial binding residue => ECO:0000269|PubMed:9931255
ChainResidueDetails
CTYR355
DTYR355
ATYR355
BTYR355

218500

数据于2024-04-17公开中

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