1A31
HUMAN RECONSTITUTED DNA TOPOISOMERASE I IN COVALENT COMPLEX WITH A 22 BASE PAIR DNA DUPLEX
Functional Information from GO Data
Functional Information from PROSITE/UniProt
| site_id | PS00176 |
| Number of Residues | 19 |
| Details | TOPO_IB_1 Topoisomerase (Topo) IB-type active site signature. EnkqialGTSKlnYLdprI |
| Chain | Residue | Details |
| A | GLU710-ILE728 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: O-(3'-phospho-DNA)-tyrosine intermediate => ECO:0000255|PROSITE-ProRule:PRU01382, ECO:0000255|PROSITE-ProRule:PRU10130, ECO:0000269|PubMed:10841763, ECO:0000269|PubMed:12426403, ECO:0000269|PubMed:12533542, ECO:0000269|PubMed:15165849, ECO:0000269|PubMed:15801827, ECO:0000269|PubMed:16033260, ECO:0000269|PubMed:9488644 |
| Chain | Residue | Details |
| A | PTR723 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | SITE: Interaction with DNA |
| Chain | Residue | Details |
| A | ARG316 | |
| A | ARG364 | |
| A | TRP412 | |
| A | LYS443 | |
| A | THR501 | |
| A | LYS532 | |
| A | ASN574 | |
| A | HIS632 | |
| A | LYS650 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
| Chain | Residue | Details |
| A | LYS280 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by CK2 => ECO:0000269|PubMed:23185622 |
| Chain | Residue | Details |
| A | SER506 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS204 | |
| A | LYS549 | |
| A | LYS642 | |
| A | LYS700 | |
| A | LYS712 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| A | LYS336 |
