1A2A

AGKISTROTOXIN, A PHOSPHOLIPASE A2-TYPE PRESYNAPTIC NEUROTOXIN FROM AGKISTRODON HALYS PALLAS

GO（遺伝子オントロジー）由来の情報

鎖名	GO（遺伝子オントロジー）id	名前空間	内容
A	0004623	molecular_function	phospholipase A2 activity
A	0005509	molecular_function	calcium ion binding
A	0005543	molecular_function	phospholipid binding
A	0005576	cellular_component	extracellular region
A	0006629	biological_process	lipid metabolic process
A	0006644	biological_process	phospholipid metabolic process
A	0016042	biological_process	lipid catabolic process
A	0016787	molecular_function	hydrolase activity
A	0035821	biological_process	modulation of process of another organism
A	0042130	biological_process	negative regulation of T cell proliferation
A	0046872	molecular_function	metal ion binding
A	0047498	molecular_function	calcium-dependent phospholipase A2 activity
A	0050482	biological_process	arachidonic acid secretion
A	0090729	molecular_function	toxin activity
B	0004623	molecular_function	phospholipase A2 activity
B	0005509	molecular_function	calcium ion binding
B	0005543	molecular_function	phospholipid binding
B	0005576	cellular_component	extracellular region
B	0006629	biological_process	lipid metabolic process
B	0006644	biological_process	phospholipid metabolic process
B	0016042	biological_process	lipid catabolic process
B	0016787	molecular_function	hydrolase activity
B	0035821	biological_process	modulation of process of another organism
B	0042130	biological_process	negative regulation of T cell proliferation
B	0046872	molecular_function	metal ion binding
B	0047498	molecular_function	calcium-dependent phospholipase A2 activity
B	0050482	biological_process	arachidonic acid secretion
B	0090729	molecular_function	toxin activity
C	0004623	molecular_function	phospholipase A2 activity
C	0005509	molecular_function	calcium ion binding
C	0005543	molecular_function	phospholipid binding
C	0005576	cellular_component	extracellular region
C	0006629	biological_process	lipid metabolic process
C	0006644	biological_process	phospholipid metabolic process
C	0016042	biological_process	lipid catabolic process
C	0016787	molecular_function	hydrolase activity
C	0035821	biological_process	modulation of process of another organism
C	0042130	biological_process	negative regulation of T cell proliferation
C	0046872	molecular_function	metal ion binding
C	0047498	molecular_function	calcium-dependent phospholipase A2 activity
C	0050482	biological_process	arachidonic acid secretion
C	0090729	molecular_function	toxin activity
D	0004623	molecular_function	phospholipase A2 activity
D	0005509	molecular_function	calcium ion binding
D	0005543	molecular_function	phospholipid binding
D	0005576	cellular_component	extracellular region
D	0006629	biological_process	lipid metabolic process
D	0006644	biological_process	phospholipid metabolic process
D	0016042	biological_process	lipid catabolic process
D	0016787	molecular_function	hydrolase activity
D	0035821	biological_process	modulation of process of another organism
D	0042130	biological_process	negative regulation of T cell proliferation
D	0046872	molecular_function	metal ion binding
D	0047498	molecular_function	calcium-dependent phospholipase A2 activity
D	0050482	biological_process	arachidonic acid secretion
D	0090729	molecular_function	toxin activity
E	0004623	molecular_function	phospholipase A2 activity
E	0005509	molecular_function	calcium ion binding
E	0005543	molecular_function	phospholipid binding
E	0005576	cellular_component	extracellular region
E	0006629	biological_process	lipid metabolic process
E	0006644	biological_process	phospholipid metabolic process
E	0016042	biological_process	lipid catabolic process
E	0016787	molecular_function	hydrolase activity
E	0035821	biological_process	modulation of process of another organism
E	0042130	biological_process	negative regulation of T cell proliferation
E	0046872	molecular_function	metal ion binding
E	0047498	molecular_function	calcium-dependent phospholipase A2 activity
E	0050482	biological_process	arachidonic acid secretion
E	0090729	molecular_function	toxin activity
F	0004623	molecular_function	phospholipase A2 activity
F	0005509	molecular_function	calcium ion binding
F	0005543	molecular_function	phospholipid binding
F	0005576	cellular_component	extracellular region
F	0006629	biological_process	lipid metabolic process
F	0006644	biological_process	phospholipid metabolic process
F	0016042	biological_process	lipid catabolic process
F	0016787	molecular_function	hydrolase activity
F	0035821	biological_process	modulation of process of another organism
F	0042130	biological_process	negative regulation of T cell proliferation
F	0046872	molecular_function	metal ion binding
F	0047498	molecular_function	calcium-dependent phospholipase A2 activity
F	0050482	biological_process	arachidonic acid secretion
F	0090729	molecular_function	toxin activity
G	0004623	molecular_function	phospholipase A2 activity
G	0005509	molecular_function	calcium ion binding
G	0005543	molecular_function	phospholipid binding
G	0005576	cellular_component	extracellular region
G	0006629	biological_process	lipid metabolic process
G	0006644	biological_process	phospholipid metabolic process
G	0016042	biological_process	lipid catabolic process
G	0016787	molecular_function	hydrolase activity
G	0035821	biological_process	modulation of process of another organism
G	0042130	biological_process	negative regulation of T cell proliferation
G	0046872	molecular_function	metal ion binding
G	0047498	molecular_function	calcium-dependent phospholipase A2 activity
G	0050482	biological_process	arachidonic acid secretion
G	0090729	molecular_function	toxin activity
H	0004623	molecular_function	phospholipase A2 activity
H	0005509	molecular_function	calcium ion binding
H	0005543	molecular_function	phospholipid binding
H	0005576	cellular_component	extracellular region
H	0006629	biological_process	lipid metabolic process
H	0006644	biological_process	phospholipid metabolic process
H	0016042	biological_process	lipid catabolic process
H	0016787	molecular_function	hydrolase activity
H	0035821	biological_process	modulation of process of another organism
H	0042130	biological_process	negative regulation of T cell proliferation
H	0046872	molecular_function	metal ion binding
H	0047498	molecular_function	calcium-dependent phospholipase A2 activity
H	0050482	biological_process	arachidonic acid secretion
H	0090729	molecular_function	toxin activity

PDBデータベースに由来する情報

site_id	AC1
残基数	3
詳細	BINDING SITE FOR RESIDUE CL D 200

鎖名	残基
A	ARG108
D	GLN4
D	TYR75

site_id	AC2
残基数	1
詳細	BINDING SITE FOR RESIDUE CL C 400

鎖名	残基
C	ARG108

site_id	AC3
残基数	2
詳細	BINDING SITE FOR RESIDUE CL E 600

鎖名	残基
E	ARG108
H	GLN4

site_id	AC4
残基数	3
詳細	BINDING SITE FOR RESIDUE CL F 800

鎖名	残基
F	GLN4
F	TYR75
G	ARG108

UniProtにおけるモチーフ・データベースPROSITEからの機能情報

site_id	PS00118
残基数	8
詳細	PA2_HIS Phospholipase A2 histidine active site. CCFvHDcC

鎖名	残基	詳細
A	CYS44-CYS51

site_id	PS00119
残基数	11
詳細	PA2_ASP Phospholipase A2 aspartic acid active site. ICECDRVAaEC

鎖名	残基	詳細
A	ILE95-CYS105

SwissProt/UniProtに記載されている蛋白質分子機能情報

site_id	SWS_FT_FI1
残基数	16
詳細	ACT_SITE: ACT_SITE => ECO:0000305\|PubMed:9733637

鎖名	残基	詳細
A	HIS48
A	ASP99
B	HIS48
B	ASP99
C	HIS48
C	ASP99
D	HIS48
D	ASP99
E	HIS48
E	ASP99
F	HIS48
F	ASP99
G	HIS48
G	ASP99
H	HIS48
H	ASP99

site_id	SWS_FT_FI2
残基数	32
詳細	BINDING: BINDING => ECO:0000269\|PubMed:10666574, ECO:0007744\|PDB:1BJJ

鎖名	残基	詳細
G	TYR28
G	GLY30
G	GLY32
G	ASP49
H	TYR28
H	GLY30
H	GLY32
H	ASP49
A	TYR28
A	GLY30
A	GLY32
A	ASP49
B	TYR28
B	GLY30
B	GLY32
B	ASP49
C	TYR28
C	GLY30
C	GLY32
C	ASP49
D	TYR28
D	GLY30
D	GLY32
D	ASP49
E	TYR28
E	GLY30
E	GLY32
E	ASP49
F	TYR28
F	GLY30
F	GLY32
F	ASP49

		Sequence (fasta)
		PDBx/mmCIF
		PDBML (ヘッダのみ (no-atom))
		PDB形式 (全ての情報)
		検証レポート (PDF)
		EDMap 2fo-fc (MTZ)