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5Q01

Human liver fructose-1,6-bisphosphatase 1 (fructose 1,6-bisphosphate 1-phosphatase, E.C.3.1.3.11) complexed with the allosteric inhibitor 1-(5-bromo-1,3-thiazol-2-yl)-3-[4-(4,5-dichloro-2-methylpyrazol-3-yl)oxyphenyl]sulfonylurea

Experimental procedure
Experimental methodSINGLE WAVELENGTH
Source typeSYNCHROTRON
Source detailsSLS BEAMLINE X10SA
Synchrotron siteSLS
BeamlineX10SA
Temperature [K]100
Detector technologyCCD
Collection date2005-12-27
DetectorMAR CCD 165 mm
Wavelength(s)0.987
Spacegroup nameP 1 21 1
Unit cell lengths66.435, 294.192, 83.569
Unit cell angles90.00, 97.56, 90.00
Refinement procedure
Resolution30.406 - 2.603
R-factor0.1908
Rwork0.187
R-free0.26690
Structure solution methodMOLECULAR REPLACEMENT
RMSD bond length0.008
RMSD bond angle1.085
Refinement softwarePHENIX (1.11.1_2575)
Data quality characteristics
 Overall
Low resolution limit [Å]30.406
High resolution limit [Å]2.603
Number of reflections76273
Completeness [%]78.8
Crystallization Conditions
crystal IDmethodpHtemperaturedetails
1VAPOR DIFFUSION, SITTING DROP73000.1M HEPES pH 7.0, 0.1M AMMONIUM ACETATE, 12%-25% PEG 3350

217705

数据于2024-03-27公开中

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