7N26
 
 | | NMR structure of EpI-[Y(SO3)15Y]-NH2 | | Descriptor: | Alpha-conotoxin EpI | | Authors: | Conibear, A.C, Rosengren, K.J, Lee, H.S. | | Deposit date: | 2021-05-28 | | Release date: | 2021-11-17 | | Method: | SOLUTION NMR | | Cite: | Posttranslational modifications of alpha-conotoxins: sulfotyrosine and C-terminal amidation stabilise structures and increase acetylcholine receptor binding.
Rsc Med Chem, 12, 2021
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7N45
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7N7D
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7N7E
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7N82
 | | NMR Solution structure of Se0862 | | Descriptor: | Biofilm-related protein | | Authors: | Zhang, N, LiWang, A.L. | | Deposit date: | 2021-06-11 | | Release date: | 2021-07-14 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Assessment of prediction methods for protein structures determined by NMR in CASP14: Impact of AlphaFold2.
Proteins, 89, 2021
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7N87
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7N99
 | | SDE2 SAP domain apo structure | | Descriptor: | Isoform 2 of Replication stress response regulator SDE2 | | Authors: | Paung, Y, Weinheimer, A.S, Rageul, J, Khan, A, Ho, B, Tong, M, Alphonse, S, Seeliger, M.A, Kim, H. | | Deposit date: | 2021-06-17 | | Release date: | 2022-10-12 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Extended DNA-binding interfaces beyond the canonical SAP domain contribute to the function of replication stress regulator SDE2 at DNA replication forks.
J.Biol.Chem., 298, 2022
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7NBK
 | | Solution structure of DNA duplex containing a 2'-deoxy-2'2'-difluorodeoxycytidine (gemcitabine) modification | | Descriptor: | DNA (5'-D(*CP*GP*TP*AP*(FFC)P*G)-3') | | Authors: | Cabrero, C, Martin-Pintado, N, Mazzini, S, Gargallo, R, Eritja, R, Avino, A, Gonzalez, C. | | Deposit date: | 2021-01-27 | | Release date: | 2021-04-07 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural Effects of Incorporation of 2 -Deoxy-2 2 -difluorodeoxycytidine (Gemcitabine) in A- and B-form Duplexes.
Chemistry, 2021
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7NBL
 | | Solution structure of DNA:RNA hybrid containing a 2'-deoxy-2'2'-difluorodeoxycytidine (gemcitabine) modification | | Descriptor: | DNA (5'-D(*CP*TP*AP*(FFC)P*AP*CP*GP*G)-3'), RNA (5'-R(*CP*CP*GP*UP*GP*UP*AP*G)-3') | | Authors: | Cabrero, C, Martin-Pintado, N, Mazzini, S, Gargallo, R, Eritja, R, Avino, A, Gonzalez, C. | | Deposit date: | 2021-01-27 | | Release date: | 2021-04-07 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural Effects of Incorporation of 2 -Deoxy-2 2 -difluorodeoxycytidine (Gemcitabine) in A- and B-form Duplexes.
Chemistry, 2021
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7NBP
 | | Solution structure of DNA duplex containing a 7,8-dihydro-8-oxo-1,N6-ethenoadenine base modification that induces exclusively A->T transversions in Escherichia coli | | Descriptor: | DNA (5'-D(*CP*AP*TP*GP*AP*GP*TP*AP*C)-3'), DNA (5'-D(*GP*TP*AP*CP*(EDA)P*CP*AP*TP*G)-3') | | Authors: | Aralov, A.V, Gubina, N, Cabrero, C, Tsvetkov, V.B, Turaev, A.V, Fedeles, B.I, Croy, R.G, Isaakova, E.A, Melnik, D, Dukova, S, Khrulev, A.A, Varizhuk, A.M, Gonzalez, C, Zatsepin, T.S, Essigmann, J.M. | | Deposit date: | 2021-01-27 | | Release date: | 2022-03-02 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | 7,8-Dihydro-8-oxo-1,N6-ethenoadenine: an exclusively Hoogsteen-paired thymine mimic in DNA that induces A→T transversions in Escherichia coli.
Nucleic Acids Res., 50, 2022
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7ND1
 | | First-in-class small molecule inhibitors of Polycomb Repressive Complex 1 (PRC1) RING domain | | Descriptor: | 3-(2-chlorophenyl)-4-ethyl-5-(1~{H}-indol-4-yl)-1~{H}-pyrrole-2-carboxylic acid, E3 ubiquitin-protein ligase RING2, Polycomb complex protein BMI-1, ... | | Authors: | Cierpicki, T, Lund, G, Jaremko, L. | | Deposit date: | 2021-01-29 | | Release date: | 2021-06-16 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Small-molecule inhibitors targeting Polycomb repressive complex 1 RING domain.
Nat.Chem.Biol., 17, 2021
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7NE8
 | | Tick salivary protein BSAP1 | | Descriptor: | tick salivary protein BSAP1 | | Authors: | Denisov, S.S, Ippel, J.H, Castoldi, E, Hackeng, T.M, Dijkgraaf, I. | | Deposit date: | 2021-02-03 | | Release date: | 2021-06-16 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Molecular basis of anticoagulant and anticomplement activity of the tick salivary protein Salp14 and its homologs.
J.Biol.Chem., 297, 2021
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7NEJ
 | | Solution structure of DNA:RNA hybrid duplex | | Descriptor: | DNA (5'-D(*CP*TP*AP*CP*AP*CP*GP*G)-3'), RNA (5'-R(*CP*CP*GP*UP*GP*UP*AP*G)-3') | | Authors: | Cabrero, C, Martin-Pintado, N, Mazzini, S, Gargallo, R, Eritja, R, Avino, A, Gonzalez, C. | | Deposit date: | 2021-02-04 | | Release date: | 2021-04-07 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Structural Effects of Incorporation of 2 -Deoxy-2 2 -difluorodeoxycytidine (Gemcitabine) in A- and B-form Duplexes.
Chemistry, 2021
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7NF9
 | | N-terminal C2H2 Zn-finger domain of Clamp | | Descriptor: | Chromatin-linked adaptor for MSL proteins, isoform A, ZINC ION | | Authors: | Mariasina, S.S, Bonchuk, A.N, Tikhonova, E.A, Efimov, S.V, Maksimenko, O.G, Georgiev, P.G, Polshakov, V.I. | | Deposit date: | 2021-02-05 | | Release date: | 2021-12-29 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Structural basis for interaction between CLAMP and MSL2 proteins involved in the specific recruitment of the dosage compensation complex in Drosophila.
Nucleic Acids Res., 50, 2022
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7NHZ
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7NIP
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7NKV
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7NM2
 | | Solution structure of MLKL executioner domain in complex with a fragment | | Descriptor: | 2-[(~{S})-methoxy-(4-propan-2-ylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | | Authors: | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | Deposit date: | 2021-02-23 | | Release date: | 2021-09-22 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J.Med.Chem., 64, 2021
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7NM4
 | | Solution structure of MLKL executioner domain in complex with a fragment | | Descriptor: | (~{S})-1~{H}-benzimidazol-2-yl-(4-propan-2-ylphenyl)methanol, Mixed lineage kinase domain-like protein | | Authors: | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | Deposit date: | 2021-02-23 | | Release date: | 2021-09-22 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J.Med.Chem., 64, 2021
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7NM5
 | | Solution structure of MLKL executioner domain in complex with a fragment | | Descriptor: | 2-[(~{S})-methoxy-(4-phenylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | | Authors: | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | Deposit date: | 2021-02-23 | | Release date: | 2021-09-22 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J.Med.Chem., 64, 2021
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7NMB
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7NN6
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7NQC
 | | Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane targeting motifs | | Descriptor: | CALCIUM ION, Calmodulin-1, PRO-ASN-GLY-LYS-LYS-LYS-ARG-LYS-SER-LEU-ALA-LYS-ARG-ILE-ARG-GLU-ARG-CMF, ... | | Authors: | Chamberlain, S.G, Owen, D, Mott, H.R. | | Deposit date: | 2021-03-01 | | Release date: | 2021-09-22 | | Method: | SOLUTION NMR | | Cite: | Calmodulin extracts the Ras family protein RalA from lipid bilayers by engagement with two membrane-targeting motifs.
Proc.Natl.Acad.Sci.USA, 118, 2021
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7NRN
 | | NMR structure of GIPC1-GH2 domain | | Descriptor: | PDZ domain-containing protein GIPC1 | | Authors: | Barthe, P, Roumestand, C. | | Deposit date: | 2021-03-04 | | Release date: | 2021-04-14 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Pressure and Chemical Unfolding of an alpha-Helical Bundle Protein: The GH2 Domain of the Protein Adaptor GIPC1.
Int J Mol Sci, 22, 2021
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7NS1
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