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coronavirus
Coronavirus, 2020. Modified from the original illustration by David S. Goodsell@RCSB PDB

The recent outbreak of the Novel Coronavirus disease (COVID-19) is a serious threat to people all over the world. In order to understand and develop an effective drug against this virus (Severe Acute Respiratory Syndrome Coronavirus 2: SARS-CoV-2), structural work on the related proteins has already started and the resultant entries are accumulating in the PDB. PDBj provides a portal page for the COVID-19 related entries for our users. New entries will be added simultaneously with the public release from the wwPDB.

An explanation article covering one of the proteins of this virus is available on the "Molecules of the Month" page below:

The tab "All entries" contains all PDB IDs, in case you want to check all independent entries, including group depositions by the same authors. The "Repr. entries" tab contains only representative PDB entries with the highest resolution, excluding duplicate entries with 100% amino acid sequence identitiy, even if they contain a different ligand. Finally, the "Latest entries" tab contains the latest entries released this week.


Created: 2020-10-28 (last edited: more than 1 year ago)2022-09-02
6WEY
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BU of 6wey by Molmil
High-resolution structure of the SARS-CoV-2 NSP3 Macro X domain
Descriptor: Non-structural protein 3
Authors:Vuksanovic, N, Silvaggi, N.R.
Deposit date:2020-04-03
Release date:2020-04-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (0.95 Å)
Cite:Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3.
Biochemistry, 59, 2020
6WKP
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BU of 6wkp by Molmil
Crystal structure of RNA-binding domain of nucleocapsid phosphoprotein from SARS CoV-2, monoclinic crystal form
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Nucleoprotein, ZINC ION
Authors:Chang, C, Michalska, K, Jedrzejczak, R, Maltseva, N, Endres, M, Godzik, A, Kim, Y, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-04-16
Release date:2020-04-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Epitopes recognition of SARS-CoV-2 nucleocapsid RNA binding domain by human monoclonal antibodies.
Iscience, 27, 2024
6WLC
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BU of 6wlc by Molmil
Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with Uridine-5'-Monophosphate
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ACETATE ION, ...
Authors:Kim, Y, Maltseva, N, Jedrzejczak, R, Endres, M, Chang, C, Godzik, A, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-04-19
Release date:2020-04-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Commun Biol, 4, 2021
6YHU
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BU of 6yhu by Molmil
Crystal structure of the nsp7-nsp8 complex of SARS-CoV-2
Descriptor: Replicase polyprotein 1a
Authors:Konkolova, E, Klima, M, Boura, E.
Deposit date:2020-03-31
Release date:2020-04-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of the putative SARS-CoV-2 primase complex.
J.Struct.Biol., 211, 2020
6YM0
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BU of 6ym0 by Molmil
Crystal structure of the SARS-CoV-2 receptor binding domain in complex with CR3022 Fab (crystal form 1)
Descriptor: Spike glycoprotein, heavy chain, light chain
Authors:Huo, J, Zhao, Y, Ren, J, Zhou, D, Ginn, H.M, Fry, E.E, Owens, R, Stuart, D.I.
Deposit date:2020-04-07
Release date:2020-04-29
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (4.36 Å)
Cite:Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.
Cell Host Microbe, 28, 2020
6YOR
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BU of 6yor by Molmil
Structure of the SARS-CoV-2 spike S1 protein in complex with CR3022 Fab
Descriptor: IgG H chain, IgG L chain, Spike glycoprotein
Authors:Huo, J, Zhao, Y, Ren, J, Zhou, D, Duyvesteyn, H.M.E, Carrique, L, Malinauskas, T, Ruza, R.R, Shah, P.N.M, Fry, E.E, Owens, R, Stuart, D.I.
Deposit date:2020-04-15
Release date:2020-04-29
Last modified:2022-04-06
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Neutralization of SARS-CoV-2 by Destruction of the Prefusion Spike.
Cell Host Microbe, 28, 2020
6WKS
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BU of 6wks by Molmil
Structure of SARS-CoV-2 nsp16/nsp10 in complex with RNA cap analogue (m7GpppA) and S-adenosylmethionine
Descriptor: 1,2-ETHANEDIOL, 2'-O-methyltransferase, ADENOSINE, ...
Authors:Gupta, Y.K, Viswanathan, T, Arya, S, Qi, S, Misra, A, Chan, S.-H.
Deposit date:2020-04-16
Release date:2020-05-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis of RNA cap modification by SARS-CoV-2.
Nat Commun, 11, 2020
6WOJ
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BU of 6woj by Molmil
Structure of the SARS-CoV-2 macrodomain (NSP3) in complex with ADP-ribose
Descriptor: ADENOSINE-5-DIPHOSPHORIBOSE, Non-structural protein 3
Authors:Lovell, S, Kashipathy, M.M, Battaile, K.P, Gao, F.P, Fehr, A.R.
Deposit date:2020-04-24
Release date:2020-05-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase.
J.Virol., 95, 2021
6WRH
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The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant
Descriptor: CHLORIDE ION, GLYCEROL, Non-structural protein 3, ...
Authors:Osipiuk, J, Tesar, C, Jedrzejczak, R, Endres, M, Welk, L, Babnigg, G, Kim, Y, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-04-29
Release date:2020-05-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors.
Nat Commun, 12, 2021
6YVA
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BU of 6yva by Molmil
PLpro-C111S with mISG15
Descriptor: Replicase polyprotein 1a, Ubiquitin-like protein ISG15, ZINC ION
Authors:Shin, D, Dikic, I.
Deposit date:2020-04-28
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Papain-like protease regulates SARS-CoV-2 viral spread and innate immunity.
Nature, 587, 2020
6YYT
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BU of 6yyt by Molmil
Structure of replicating SARS-CoV-2 polymerase
Descriptor: RNA product, ZINC ION, nsp12, ...
Authors:Hillen, H.S, Kokic, G, Farnung, L, Dienemann, C, Tegunov, D, Cramer, P.
Deposit date:2020-05-06
Release date:2020-05-13
Last modified:2020-08-19
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structure of replicating SARS-CoV-2 polymerase.
Nature, 584, 2020
6YZ1
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BU of 6yz1 by Molmil
The crystal structure of SARS-CoV-2 nsp10-nsp16 methyltransferase complex with Sinefungin
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SINEFUNGIN, ZINC ION, ...
Authors:Krafcikova, P, Silhan, J, Nencka, R, Boura, E.
Deposit date:2020-05-06
Release date:2020-05-13
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural analysis of the SARS-CoV-2 methyltransferase complex involved in RNA cap creation bound to sinefungin.
Nat Commun, 11, 2020
7BZ5
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BU of 7bz5 by Molmil
Structure of COVID-19 virus spike receptor-binding domain complexed with a neutralizing antibody
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of B38, Light chain of B38, ...
Authors:Wu, Y, Qi, J, Gao, F.
Deposit date:2020-04-26
Release date:2020-05-13
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2.
Science, 368, 2020
6WTT
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BU of 6wtt by Molmil
Crystals Structure of the SARS-CoV-2 (COVID-19) main protease with inhibitor GC-376
Descriptor: (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, ...
Authors:Sacco, M, Ma, C, Chen, Y, Wang, J.
Deposit date:2020-05-03
Release date:2020-05-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Boceprevir, GC-376, and calpain inhibitors II, XII inhibit SARS-CoV-2 viral replication by targeting the viral main protease.
Cell Res., 30, 2020
6WUU
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BU of 6wuu by Molmil
Crystal structure of the SARS CoV-2 Papain-like protease in complex with peptide inhibitor VIR250
Descriptor: MAGNESIUM ION, Non-structural protein 3, VIR250, ...
Authors:Lv, Z, Olsen, S.K.
Deposit date:2020-05-05
Release date:2020-05-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.
Sci Adv, 6, 2020
6WX4
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BU of 6wx4 by Molmil
Crystal structure of the SARS CoV-2 Papain-like protease in complex with peptide inhibitor VIR251
Descriptor: Non-structural protein 3, VIR251, ZINC ION
Authors:Lv, Z, Olsen, S.K.
Deposit date:2020-05-09
Release date:2020-05-20
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.655 Å)
Cite:Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.
Sci Adv, 6, 2020
6WXD
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BU of 6wxd by Molmil
SARS-CoV-2 Nsp9 RNA-replicase
Descriptor: Non-structural protein 9, SULFATE ION
Authors:Littler, D.R, Gully, B.S, Riboldi-Tunnicliffe, A, Rossjohn, J.
Deposit date:2020-05-10
Release date:2020-05-20
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9.
Iscience, 23, 2020
7C22
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BU of 7c22 by Molmil
Crystal structure of the C-terminal domain of SARS-CoV-2 nucleocapsid protein
Descriptor: ACETATE ION, DI(HYDROXYETHYL)ETHER, Nucleoprotein
Authors:Zhou, R.J, Zeng, R, Lei, J.
Deposit date:2020-05-07
Release date:2020-05-20
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural characterization of the C-terminal domain of SARS-CoV-2 nucleocapsid protein.
Mol Biomed, 1, 2020
6WPS
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BU of 6wps by Molmil
Structure of the SARS-CoV-2 spike glycoprotein in complex with the S309 neutralizing antibody Fab fragment
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, S309 neutralizing antibody heavy chain, ...
Authors:Pinto, D, Park, Y.J, Beltramello, M, Walls, A.C, Tortorici, M.A, Bianchi, S, Jaconi, S, Culap, K, Zatta, F, De Marco, A, Peter, A, Guarino, B, Spreafico, R, Cameroni, E, Case, J.B, Chen, R.E, Havenar-Daughton, C, Snell, G, Virgin, H.W, Lanzavecchia, A, Diamond, M.S, Fink, K, Veesler, D, Corti, D, Seattle Structural Genomics Center for Infectious Disease (SSGCID)
Deposit date:2020-04-27
Release date:2020-05-27
Last modified:2021-05-19
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody.
Nature, 583, 2020
6WZO
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BU of 6wzo by Molmil
Structure of SARS-CoV-2 Nucleocapsid dimerization domain, P1 form
Descriptor: Nucleoprotein
Authors:Ye, Q, Corbett, K.D.
Deposit date:2020-05-14
Release date:2020-05-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein.
Protein Sci., 29, 2020
6WZQ
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BU of 6wzq by Molmil
Structure of SARS-CoV-2 Nucleocapsid dimerization domain, P21 form
Descriptor: Nucleoprotein, SULFATE ION
Authors:Ye, Q, Corbett, K.D.
Deposit date:2020-05-14
Release date:2020-05-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein.
Protein Sci., 29, 2020
6WZU
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BU of 6wzu by Molmil
The crystal structure of Papain-Like Protease of SARS CoV-2 , P3221 space group
Descriptor: CHLORIDE ION, GLYCEROL, Non-structural protein 3, ...
Authors:Osipiuk, J, Tesar, C, Endres, M, Jedrzejczak, R, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-05-14
Release date:2020-05-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors.
Nat Commun, 12, 2021
6X1B
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BU of 6x1b by Molmil
Crystal Structure of NSP15 Endoribonuclease from SARS CoV-2 in the Complex with the Product Nucleotide GpU.
Descriptor: 1,2-ETHANEDIOL, DNA (5'-R(*GP*U)-3'), PHOSPHATE ION, ...
Authors:Kim, Y, Maltseva, N, Jedrzejczak, R, Welk, L, Endres, M, Chang, C, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2020-05-18
Release date:2020-05-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Tipiracil binds to uridine site and inhibits Nsp15 endoribonuclease NendoU from SARS-CoV-2.
Commun Biol, 4, 2021
6X29
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BU of 6x29 by Molmil
SARS-CoV-2 rS2d Down State Spike Protein Trimer
Descriptor: Spike glycoprotein
Authors:Henderson, R, Acharya, P.
Deposit date:2020-05-20
Release date:2020-05-27
Last modified:2020-10-21
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Controlling the SARS-CoV-2 spike glycoprotein conformation.
Nat.Struct.Mol.Biol., 27, 2020
6X2C
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BU of 6x2c by Molmil
SARS-CoV-2 u1S2q All Down RBD State Spike Protein Trimer
Descriptor: Spike glycoprotein
Authors:Henderson, R, Acharya, P.
Deposit date:2020-05-20
Release date:2020-05-27
Last modified:2021-07-07
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Controlling the SARS-CoV-2 spike glycoprotein conformation.
Nat.Struct.Mol.Biol., 27, 2020

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