PDB-6hhq: Crystal structure of compound C45 bound to the yeast 80S ribosome

Basic information

• Entry: Database: PDB / ID: 6hhq
• Title: Crystal structure of compound C45 bound to the yeast 80S ribosome

Components

• (18S ribosomal ...) x 2
• (40S ribosomal protein ...) x 31
• (60S ribosomal protein ...) x 40
• 25S ribosomal RNA
• 5.8S ribosomal RNA
• 5S ribosomal RNA
• 60S acidic ribosomal protein P0
• Guanine nucleotide-binding protein subunit beta-like protein
• Suppressor protein STM1
• Ubiquitin-40S ribosomal protein S31
• Ubiquitin-60S ribosomal protein L40

• Keywords: RIBOSOME / 80S ribosome / inhibitor / anti-cancer

Function / homology

Function:

ribosome hibernation / triplex DNA binding / translation elongation factor binding / regulation of translational initiation in response to stress / Platelet degranulation / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) / negative regulation of glucose mediated signaling pathway / negative regulation of translational frameshifting / Protein methylation / RMTs methylate histone arginines / positive regulation of translational fidelity / mTORC1-mediated signalling / ribosome-associated ubiquitin-dependent protein catabolic process / Protein hydroxylation / GDP-dissociation inhibitor activity / : / pre-mRNA 5'-splice site binding / positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay / Formation of the ternary complex, and subsequently, the 43S complex / Translation initiation complex formation / cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / Ribosomal scanning and start codon recognition / preribosome, small subunit precursor / translational elongation / response to cycloheximide / telomeric DNA binding / mRNA destabilization / TOR signaling / Major pathway of rRNA processing in the nucleolus and cytosol / SRP-dependent cotranslational protein targeting to membrane / 90S preribosome / GTP hydrolysis and joining of the 60S ribosomal subunit / Formation of a pool of free 40S subunits / endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) / Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) / negative regulation of mRNA splicing, via spliceosome / protein-RNA complex assembly / ribosomal small subunit export from nucleus / preribosome, large subunit precursor / L13a-mediated translational silencing of Ceruloplasmin expression / translation regulator activity / ribosomal large subunit export from nucleus / G-protein alpha-subunit binding / endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / regulation of translational fidelity / positive regulation of protein kinase activity / rescue of stalled ribosome / translational termination / maturation of SSU-rRNA / translation repressor activity / maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / maturation of LSU-rRNA / ribosomal large subunit biogenesis / DNA-(apurinic or apyrimidinic site) endonuclease activity / maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) / cellular response to amino acid starvation / ribosome assembly / telomere maintenance / small-subunit processome / protein kinase C binding / maintenance of translational fidelity / macroautophagy / modification-dependent protein catabolic process / ribosomal small subunit biogenesis / small ribosomal subunit rRNA binding / protein tag activity / rRNA processing / ribosomal small subunit assembly / cytoplasmic stress granule / ribosomal large subunit assembly / cytosolic small ribosomal subunit / large ribosomal subunit rRNA binding / ribosome binding / ribosome biogenesis / small ribosomal subunit / 5S rRNA binding / cytoplasmic translation / cytosolic large ribosomal subunit / negative regulation of translation / rRNA binding / protein ubiquitination / ribosome / structural constituent of ribosome / positive regulation of protein phosphorylation / translation / G protein-coupled receptor signaling pathway / response to antibiotic / negative regulation of gene expression / mRNA binding / ubiquitin protein ligase binding / nucleolus / negative regulation of apoptotic process / perinuclear region of cytoplasm / mitochondrion / DNA binding / RNA binding / zinc ion binding / nucleoplasm / metal ion binding

Domain/homology:

Stm1-like, N-terminal / Stm1 / Hyaluronan/mRNA-binding protein / Hyaluronan / mRNA binding family / 60s Acidic ribosomal protein / 60S acidic ribosomal protein P0 / : / : / Ribosomal protein S12e / 50S ribosomal protein L10, insertion domain superfamily / 60S ribosomal protein L10P, insertion domain / Insertion domain in 60S ribosomal protein L10P / Small (40S) ribosomal subunit Asc1/RACK1 / Ribosomal protein S19e, conserved site / : / S27a-like superfamily / Ribosomal protein S10, eukaryotic/archaeal / Ribosomal protein S25 / Ribosomal protein S26e signature. / Ribosomal protein S17e, conserved site / : / Ribosomal protein S30 / 40S ribosomal protein S29/30S ribosomal protein S14 type Z / Ribosomal protein S27a / Ribosomal protein S27a / Ribosomal protein L29e / Ribosomal protein S3, eukaryotic/archaeal / Ribosomal protein S8e subdomain, eukaryotes / S25 ribosomal protein / Ribosomal protein L10e, conserved site / Ribosomal protein L41 / Ribosomal protein L41 / Ribosomal protein S26e / Ribosomal protein S26e superfamily / Ribosomal protein S26e / Ribosomal protein L10e / Ribosomal protein L27e, conserved site / Ribosomal protein S19A/S15e / Ribosomal protein S21e, conserved site / Ribosomal protein S21e signature. / Ribosomal L29e protein family / Ribosomal protein S30 / Ribosomal protein S3Ae, conserved site / Ribosomal protein S12e signature. / Ribosomal protein S17e / Ribosomal protein S17e-like superfamily / Ribosomal protein S27a / Ribosomal protein S19e / Ribosomal_S19e / Ribosomal protein S8e, conserved site / Ribosomal protein S5, eukaryotic/archaeal / 40S ribosomal protein S11, N-terminal / 40S ribosomal protein S1/3, eukaryotes / Ribosomal protein S6, eukaryotic / Ribosomal protein S2, eukaryotic / Ribosomal protein L24e, conserved site / Ribosomal protein S7e / 40S ribosomal protein S4, C-terminal domain / Ribosomal protein L34e, conserved site / Eukaryotic Ribosomal Protein L27, KOW domain / Ribosomal protein S4e, N-terminal, conserved site / Ribosomal S17 / Ribosomal protein S19e signature. / Ribosomal protein L44e / Ribosomal protein L38e / Ribosomal protein L38e superfamily / Ribosomal protein L27e / Ribosomal protein S21e / Ribosomal protein S21e superfamily / Ribosomal protein L27e superfamily / Ribosomal protein S21e / Ribosomal protein S19e / Ribosomal protein S27, zinc-binding domain superfamily / Ribosomal L38e protein family / Ribosomal protein L23/L25, N-terminal / 40S Ribosomal protein S10 / 60S ribosomal protein L35 / Ribosomal protein S17, archaeal/eukaryotic / Ribosomal protein S27 / Ribosomal protein S28e conserved site / Ribosomal protein S6/S6e/A/B/2, conserved site / Ribosomal protein S28e / Ribosomal protein L35Ae, conserved site / Ribosomal protein L30e, conserved site / 40S ribosomal protein S4 C-terminus / Ribosomal protein S4e, N-terminal / Ribosomal protein S23, eukaryotic/archaeal / Ribosomal_S17 N-terminal / Plectin/S10, N-terminal / Ribosomal protein S3Ae / Ribosomal S3Ae family / Ribosomal protein L44 / Ribosomal protein L34Ae / Ribosomal protein S7e / Ribosomal protein L23, N-terminal domain / Ribosomal protein L13e, conserved site / Ribosomal protein L13e signature. / Plectin/S10 domain / Ribosomal protein S2, eukaryotic/archaeal / Ribosomal protein S8e

Component:

Chem-G5B / osmium (III) hexammine / : / : / : / : / RNA / RNA (> 10) / RNA (> 100) / RNA (> 1000) / Small ribosomal subunit protein uS4A / Large ribosomal subunit protein uL15 / Small ribosomal subunit protein eS17A / Large ribosomal subunit protein eL24A / Large ribosomal subunit protein uL23 / Large ribosomal subunit protein eL39 / Large ribosomal subunit protein uL10 / Large ribosomal subunit protein uL30A / Large ribosomal subunit protein uL6A / Large ribosomal subunit protein uL22A / Large ribosomal subunit protein uL24A / Large ribosomal subunit protein eL33A / Large ribosomal subunit protein eL36A / Large ribosomal subunit protein eL29 / Large ribosomal subunit protein eL15A / Large ribosomal subunit protein eL22A / Small ribosomal subunit protein uS3 / Small ribosomal subunit protein uS15 / Ubiquitin-ribosomal protein eS31 fusion protein / Small ribosomal subunit protein eS19A / Small ribosomal subunit protein eS21A / Small ribosomal subunit protein uS8A / Large ribosomal subunit protein eL27A / Large ribosomal subunit protein eL31A / Ubiquitin-ribosomal protein eL40A fusion protein / Large ribosomal subunit protein eL20A / Large ribosomal subunit protein eL43A / Large ribosomal subunit protein eL42A / Small ribosomal subunit protein uS12A / Small ribosomal subunit protein eS24A / Small ribosomal subunit protein eS30A / Small ribosomal subunit protein eS4A / Small ribosomal subunit protein eS6A / Small ribosomal subunit protein eS8A / Large ribosomal subunit protein uL14A / Large ribosomal subunit protein uL2A / Small ribosomal subunit protein uS17A / Large ribosomal subunit protein eL18A / Small ribosomal subunit protein uS9A / Small ribosomal subunit protein uS13A / Large ribosomal subunit protein eL19A / Large ribosomal subunit protein uL29A / Small ribosomal subunit protein eS32B / Large ribosomal subunit protein uL4A / Large ribosomal subunit protein eL30 / Large ribosomal subunit protein uL3 / Large ribosomal subunit protein eL8A / Small ribosomal subunit protein uS5 / Large ribosomal subunit protein uL18 / Small ribosomal subunit protein uS7 / Large ribosomal subunit protein uL13A / Small ribosomal subunit protein eS7A / Small ribosomal subunit protein uS2A / Small ribosomal subunit protein eS1A / Small ribosomal subunit protein eS27A / Large ribosomal subunit protein eL14A / Small ribosomal subunit protein RACK1 / Large ribosomal subunit protein eL32 / Small ribosomal subunit protein uS10 / Suppressor protein STM1 / Small ribosomal subunit protein uS11B / Small ribosomal subunit protein eS26B / Small ribosomal subunit protein uS14A / Large ribosomal subunit protein uL16 / Small ribosomal subunit protein eS12 / Large ribosomal subunit protein eL37A / Large ribosomal subunit protein eL38 / Large ribosomal subunit protein eL34A / Small ribosomal subunit protein uS19 / Large ribosomal subunit protein eL6A / Large ribosomal subunit protein eL21A / Small ribosomal subunit protein eS10A / Large ribosomal subunit protein eL13A / Large ribosomal subunit protein uL5B / Small ribosomal subunit protein eS25A / Small ribosomal subunit protein eS28A

• Biological species: Saccharomyces cerevisiae (brewer's yeast)
• Method: X-RAY DIFFRACTION / SYNCHROTRON / Resolution: 3.10000049683 Å
• Authors: Pellegrino, S. / Vanderwal, C.D. / Yusupov, M.

Funding support

France, United States, 5items

Organization	Grant number	Country
French National Research Agency	ANR-15-CE11-0021-01	France
	FRM - DBF20160635745	France
European Research Council	294312
	NIH - GM079238	United States
	NIH - GM129264	United States

• Citation: Journal: Nucleic Acids Res. / Year: 2019; Title: Understanding the role of intermolecular interactions between lissoclimides and the eukaryotic ribosome.; Authors: Pellegrino, S. / Meyer, M. / Konst, Z.A. / Holm, M. / Voora, V.K. / Kashinskaya, D. / Zanette, C. / Mobley, D.L. / Yusupova, G. / Vanderwal, C.D. / Blanchard, S.C. / Yusupov, M.

History

Deposition	Aug 28, 2018	Deposition site: PDBE / Processing site: PDBE
Revision 1.0	Feb 20, 2019	Provider: repository / Type: Initial release
Revision 1.1	Feb 27, 2019	Group: Data collection / Database references Category: citation / citation_author / database_PDB_rev / database_PDB_rev_record / pdbx_database_proc Item: _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year
Revision 1.2	Apr 17, 2019	Group: Data collection / Database references / Category: citation / pdbx_database_proc Item: _citation.journal_volume / _citation.page_first / _citation.page_last

Assembly

Deposited unit

1: 25S ribosomal RNA

3: 5S ribosomal RNA

4: 5.8S ribosomal RNA

j: 60S ribosomal protein L2-A

k: 60S ribosomal protein L3

l: 60S ribosomal protein L4-A

m: 60S ribosomal protein L5

n: 60S ribosomal protein L6-A

o: 60S ribosomal protein L7-A

p: 60S ribosomal protein L8-A

q: 60S ribosomal protein L9-A

r: 60S ribosomal protein L10

s: 60S ribosomal protein L11-B

t: 60S ribosomal protein L13-A

u: 60S ribosomal protein L14-A

v: 60S ribosomal protein L15-A

w: 60S ribosomal protein L16-A

x: 60S ribosomal protein L17-A

y: 60S ribosomal protein L18-A

z: 60S ribosomal protein L19-A

0: 60S ribosomal protein L20-A

2: 60S ribosomal protein L21-A

5: 60S ribosomal protein L22-A

6: 60S ribosomal protein L23-A

7: 60S ribosomal protein L24-A

8: 60S ribosomal protein L25

9: 60S ribosomal protein L26-A

AA: 60S ribosomal protein L27-A

AB: 60S ribosomal protein L28

AC: 60S ribosomal protein L29

AD: 60S ribosomal protein L30

AE: 60S ribosomal protein L31-A

AF: 60S ribosomal protein L32

AG: 60S ribosomal protein L33-A

AH: 60S ribosomal protein L34-A

AI: 60S ribosomal protein L35-A

AJ: 60S ribosomal protein L36-A

AK: 60S ribosomal protein L37-A

AL: 60S ribosomal protein L38

AM: 60S ribosomal protein L39

AN: Ubiquitin-60S ribosomal protein L40

AO: 60S ribosomal protein L41-B

AP: 60S ribosomal protein L42-A

AQ: 60S ribosomal protein L43-A

i: Suppressor protein STM1

AR: 25S ribosomal RNA

AS: 5S ribosomal RNA

AT: 5.8S ribosomal RNA

CD: 60S ribosomal protein L2-A

CE: 60S ribosomal protein L3

CF: 60S ribosomal protein L4-A

CG: 60S ribosomal protein L5

CH: 60S ribosomal protein L6-A

CI: 60S ribosomal protein L7-A

CJ: 60S ribosomal protein L8-A

CK: 60S ribosomal protein L9-A

CL: 60S ribosomal protein L10

CM: 60S ribosomal protein L11-B

CN: 60S ribosomal protein L13-A

CO: 60S ribosomal protein L14-A

CP: 60S ribosomal protein L15-A

CQ: 60S ribosomal protein L16-A

CR: 60S ribosomal protein L17-A

CS: 60S ribosomal protein L18-A

CT: 60S ribosomal protein L19-A

CU: 60S ribosomal protein L20-A

CV: 60S ribosomal protein L21-A

CW: 60S ribosomal protein L22-A

CX: 60S ribosomal protein L23-A

CY: 60S ribosomal protein L24-A

CZ: 60S ribosomal protein L25

DA: 60S ribosomal protein L26-A

DB: 60S ribosomal protein L27-A

DC: 60S ribosomal protein L28

DD: 60S ribosomal protein L29

DE: 60S ribosomal protein L30

DF: 60S ribosomal protein L31-A

DG: 60S ribosomal protein L32

DH: 60S ribosomal protein L33-A

DI: 60S ribosomal protein L34-A

DJ: 60S ribosomal protein L35-A

DK: 60S ribosomal protein L36-A

DL: 60S ribosomal protein L37-A

DM: 60S ribosomal protein L38

DN: 60S ribosomal protein L39

DO: Ubiquitin-60S ribosomal protein L40

DP: 60S ribosomal protein L41-B

DQ: 60S ribosomal protein L42-A

DR: 60S ribosomal protein L43-A

p0: 60S acidic ribosomal protein P0

sM: Suppressor protein STM1

A: 18S ribosomal RNA

B: 40S ribosomal protein S0-A

C: 40S ribosomal protein S1-A

D: 40S ribosomal protein S2

E: 40S ribosomal protein S3

F: 40S ribosomal protein S4-A

G: 40S ribosomal protein S5

H: 40S ribosomal protein S6-A

I: 40S ribosomal protein S7-A

J: 40S ribosomal protein S8-A

K: 40S ribosomal protein S9-A

L: 40S ribosomal protein S10-A

M: 40S ribosomal protein S11-A

N: 40S ribosomal protein S12

O: 40S ribosomal protein S13

P: 40S ribosomal protein S14-B

Q: 40S ribosomal protein S15

R: 40S ribosomal protein S16-A

S: 40S ribosomal protein S17-A

T: 40S ribosomal protein S18-A

U: 40S ribosomal protein S19-A

V: 40S ribosomal protein S20

W: 40S ribosomal protein S21-A

X: 40S ribosomal protein S22-A

Y: 40S ribosomal protein S23-A

Z: 40S ribosomal protein S24-A

a: 40S ribosomal protein S25-A

b: 40S ribosomal protein S26-B

c: 40S ribosomal protein S27-A

d: 40S ribosomal protein S28-A

e: 40S ribosomal protein S29-A

f: 40S ribosomal protein S30-A

g: Ubiquitin-40S ribosomal protein S31

h: Guanine nucleotide-binding protein subunit beta-like protein

sR: 18S ribosomal RNA

Rb: Guanine nucleotide-binding protein subunit beta-like protein

s0: 40S ribosomal protein S0-A

s1: 40S ribosomal protein S1-A

s2: 40S ribosomal protein S2

s3: 40S ribosomal protein S3

s4: 40S ribosomal protein S4-A

s5: 40S ribosomal protein S5

s6: 40S ribosomal protein S6-A

s7: 40S ribosomal protein S7-A

s8: 40S ribosomal protein S8-A

s9: 40S ribosomal protein S9-A

c0: 40S ribosomal protein S10-A

c1: 40S ribosomal protein S11-A

c2: 40S ribosomal protein S12

c3: 40S ribosomal protein S13

c4: 40S ribosomal protein S14-B

c5: 40S ribosomal protein S15

c6: 40S ribosomal protein S16-A

c7: 40S ribosomal protein S17-A

c8: 40S ribosomal protein S18-A

c9: 40S ribosomal protein S19-A

d0: 40S ribosomal protein S20

d1: 40S ribosomal protein S21-A

d2: 40S ribosomal protein S22-A

d3: 40S ribosomal protein S23-A

d4: 40S ribosomal protein S24-A

d5: 40S ribosomal protein S25-A

d6: 40S ribosomal protein S26-B

d7: 40S ribosomal protein S27-A

d8: 40S ribosomal protein S28-A

d9: 40S ribosomal protein S29-A

e0: 40S ribosomal protein S30-A

e1: Ubiquitin-40S ribosomal protein S31

hetero molecules

Summary:

• 6.65 MDa, 159 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	6,646,165	2745
Polymers	6,304,765	159
Non-polymers	341,399	2586
Water	0

1

1: 25S ribosomal RNA

3: 5S ribosomal RNA

4: 5.8S ribosomal RNA

j: 60S ribosomal protein L2-A

k: 60S ribosomal protein L3

l: 60S ribosomal protein L4-A

m: 60S ribosomal protein L5

n: 60S ribosomal protein L6-A

o: 60S ribosomal protein L7-A

p: 60S ribosomal protein L8-A

q: 60S ribosomal protein L9-A

r: 60S ribosomal protein L10

s: 60S ribosomal protein L11-B

t: 60S ribosomal protein L13-A

u: 60S ribosomal protein L14-A

v: 60S ribosomal protein L15-A

w: 60S ribosomal protein L16-A

x: 60S ribosomal protein L17-A

y: 60S ribosomal protein L18-A

z: 60S ribosomal protein L19-A

0: 60S ribosomal protein L20-A

2: 60S ribosomal protein L21-A

5: 60S ribosomal protein L22-A

6: 60S ribosomal protein L23-A

7: 60S ribosomal protein L24-A

8: 60S ribosomal protein L25

9: 60S ribosomal protein L26-A

AA: 60S ribosomal protein L27-A

AB: 60S ribosomal protein L28

AC: 60S ribosomal protein L29

AD: 60S ribosomal protein L30

AE: 60S ribosomal protein L31-A

AF: 60S ribosomal protein L32

AG: 60S ribosomal protein L33-A

AH: 60S ribosomal protein L34-A

AI: 60S ribosomal protein L35-A

AJ: 60S ribosomal protein L36-A

AK: 60S ribosomal protein L37-A

AL: 60S ribosomal protein L38

AM: 60S ribosomal protein L39

AN: Ubiquitin-60S ribosomal protein L40

AO: 60S ribosomal protein L41-B

AP: 60S ribosomal protein L42-A

AQ: 60S ribosomal protein L43-A

i: Suppressor protein STM1

A: 18S ribosomal RNA

B: 40S ribosomal protein S0-A

C: 40S ribosomal protein S1-A

D: 40S ribosomal protein S2

E: 40S ribosomal protein S3

F: 40S ribosomal protein S4-A

G: 40S ribosomal protein S5

H: 40S ribosomal protein S6-A

I: 40S ribosomal protein S7-A

J: 40S ribosomal protein S8-A

K: 40S ribosomal protein S9-A

L: 40S ribosomal protein S10-A

M: 40S ribosomal protein S11-A

N: 40S ribosomal protein S12

O: 40S ribosomal protein S13

P: 40S ribosomal protein S14-B

Q: 40S ribosomal protein S15

R: 40S ribosomal protein S16-A

S: 40S ribosomal protein S17-A

T: 40S ribosomal protein S18-A

U: 40S ribosomal protein S19-A

V: 40S ribosomal protein S20

W: 40S ribosomal protein S21-A

X: 40S ribosomal protein S22-A

Y: 40S ribosomal protein S23-A

Z: 40S ribosomal protein S24-A

a: 40S ribosomal protein S25-A

b: 40S ribosomal protein S26-B

c: 40S ribosomal protein S27-A

d: 40S ribosomal protein S28-A

e: 40S ribosomal protein S29-A

f: 40S ribosomal protein S30-A

g: Ubiquitin-40S ribosomal protein S31

h: Guanine nucleotide-binding protein subunit beta-like protein

hetero molecules

Summary:

• defined by author
• 3.3 MDa, 79 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	3,300,295	1318
Polymers	3,135,037	79
Non-polymers	165,258	1239
Water	0

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

2

AR: 25S ribosomal RNA

AS: 5S ribosomal RNA

AT: 5.8S ribosomal RNA

CD: 60S ribosomal protein L2-A

CE: 60S ribosomal protein L3

CF: 60S ribosomal protein L4-A

CG: 60S ribosomal protein L5

CH: 60S ribosomal protein L6-A

CI: 60S ribosomal protein L7-A

CJ: 60S ribosomal protein L8-A

CK: 60S ribosomal protein L9-A

CL: 60S ribosomal protein L10

CM: 60S ribosomal protein L11-B

CN: 60S ribosomal protein L13-A

CO: 60S ribosomal protein L14-A

CP: 60S ribosomal protein L15-A

CQ: 60S ribosomal protein L16-A

CR: 60S ribosomal protein L17-A

CS: 60S ribosomal protein L18-A

CT: 60S ribosomal protein L19-A

CU: 60S ribosomal protein L20-A

CV: 60S ribosomal protein L21-A

CW: 60S ribosomal protein L22-A

CX: 60S ribosomal protein L23-A

CY: 60S ribosomal protein L24-A

CZ: 60S ribosomal protein L25

DA: 60S ribosomal protein L26-A

DB: 60S ribosomal protein L27-A

DC: 60S ribosomal protein L28

DD: 60S ribosomal protein L29

DE: 60S ribosomal protein L30

DF: 60S ribosomal protein L31-A

DG: 60S ribosomal protein L32

DH: 60S ribosomal protein L33-A

DI: 60S ribosomal protein L34-A

DJ: 60S ribosomal protein L35-A

DK: 60S ribosomal protein L36-A

DL: 60S ribosomal protein L37-A

DM: 60S ribosomal protein L38

DN: 60S ribosomal protein L39

DO: Ubiquitin-60S ribosomal protein L40

DP: 60S ribosomal protein L41-B

DQ: 60S ribosomal protein L42-A

DR: 60S ribosomal protein L43-A

p0: 60S acidic ribosomal protein P0

sM: Suppressor protein STM1

sR: 18S ribosomal RNA

Rb: Guanine nucleotide-binding protein subunit beta-like protein

s0: 40S ribosomal protein S0-A

s1: 40S ribosomal protein S1-A

s2: 40S ribosomal protein S2

s3: 40S ribosomal protein S3

s4: 40S ribosomal protein S4-A

s5: 40S ribosomal protein S5

s6: 40S ribosomal protein S6-A

s7: 40S ribosomal protein S7-A

s8: 40S ribosomal protein S8-A

s9: 40S ribosomal protein S9-A

c0: 40S ribosomal protein S10-A

c1: 40S ribosomal protein S11-A

c2: 40S ribosomal protein S12

c3: 40S ribosomal protein S13

c4: 40S ribosomal protein S14-B

c5: 40S ribosomal protein S15

c6: 40S ribosomal protein S16-A

c7: 40S ribosomal protein S17-A

c8: 40S ribosomal protein S18-A

c9: 40S ribosomal protein S19-A

d0: 40S ribosomal protein S20

d1: 40S ribosomal protein S21-A

d2: 40S ribosomal protein S22-A

d3: 40S ribosomal protein S23-A

d4: 40S ribosomal protein S24-A

d5: 40S ribosomal protein S25-A

d6: 40S ribosomal protein S26-B

d7: 40S ribosomal protein S27-A

d8: 40S ribosomal protein S28-A

d9: 40S ribosomal protein S29-A

e0: 40S ribosomal protein S30-A

e1: Ubiquitin-40S ribosomal protein S31

hetero molecules

Summary:

• defined by author
• 3.35 MDa, 80 polymers

Component details:

	Theoretical mass	Number of molelcules
Total (without water)	3,345,870	1427
Polymers	3,169,728	80
Non-polymers	176,142	1347
Water	0

Symmetry operations:

Type	Name	Symmetry operation	Number
identity operation	1_555	x,y,z	1

Unit cell

Length a, b, c (Å)	303.770, 287.950, 435.450
Angle α, β, γ (deg.)	90.000, 98.958, 90.000
Int Tables number	4
Space group name H-M	P1211
Space group name Hall	P2yb
Symmetry operation	#1: x,y,z #2: -x,y+1/2,-z

Components

RNA chain , 3 types, 6 molecules 1 AR 3 AS 4 AT

#1: RNA chain

1 AR 25S ribosomal RNA /

Details:

Mass: 1097493.875 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: GenBank: 834774822

#2: RNA chain

3 AS 5S ribosomal RNA /

Details:

Mass: 38951.105 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: GenBank: 1329886537

#3: RNA chain

4 AT 5.8S ribosomal RNA /

Details:

Mass: 50682.922 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: GenBank: 1398978137

60S ribosomal protein ... , 40 types, 80 molecules j CD k CE l CF m CG n CH o CI p CJ q CK r CL s CM t CN u CO v CP w CQ x CR ...

#4: Protein

j CD 60S ribosomal protein L2-A / Ribosome / L5 / Large ribosomal subunit protein uL2-A / RP8 / YL6

Details:

Mass: 27463.574 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX45

#5: Protein

k CE 60S ribosomal protein L3 / / Large ribosomal subunit protein uL3 / Maintenance of killer protein 8 / RP1 / Trichodermin resistance protein / YL1

Details:

Mass: 43850.793 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P14126

#6: Protein

l CF 60S ribosomal protein L4-A / Ribosome / L2 / Large ribosomal subunit protein uL4-A / RP2 / YL2

Details:

Mass: 39159.125 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P10664

#7: Protein

m CG 60S ribosomal protein L5 / / L1 / L1a / Large ribosomal subunit protein uL18 / Ribosomal 5S RNA-binding protein / YL3

Details:

Mass: 33764.828 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P26321

#8: Protein

n CH 60S ribosomal protein L6-A / Ribosome / L17 / Large ribosomal subunit protein eL6-A / RP18 / YL16

Details:

Mass: 20000.564 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: Q02326

#9: Protein

o CI 60S ribosomal protein L7-A / Ribosome / L6 / Large ribosomal subunit protein uL30-A / RP11 / YL8

Details:

Mass: 27686.281 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05737

#10: Protein

p CJ 60S ribosomal protein L8-A / Ribosome / L4 / L4-2 / L7a-1 / Large ribosomal subunit protein eL8-A / Maintenance of killer protein 7 / RP6 / YL5

Details:

Mass: 28175.820 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P17076

#11: Protein

q CK 60S ribosomal protein L9-A / Ribosome / L8 / Large ribosomal subunit protein uL6-A / RP24 / YL11

Details:

Mass: 21605.061 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05738

#12: Protein

r CL 60S ribosomal protein L10 / / L9 / Large ribosomal subunit protein uL16 / Ubiquinol-cytochrome C reductase complex subunit VI-requiring protein

Details:

Mass: 25410.465 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P41805

#13: Protein

s CM 60S ribosomal protein L11-B / Ribosome / L16 / Large ribosomal subunit protein uL5-B / RP39 / YL22

Details:

Mass: 19785.719 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: Q3E757

#14: Protein

t CN 60S ribosomal protein L13-A / Ribosome / Large ribosomal subunit protein eL13-A

Details:

Mass: 22604.164 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: Q12690

#15: Protein

u CO 60S ribosomal protein L14-A / Ribosome / Large ribosomal subunit protein eL14-A

Details:

Mass: 15195.066 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P36105

#16: Protein

v CP 60S ribosomal protein L15-A / Ribosome / L13 / Large ribosomal subunit protein eL15-A / RP15R / YL10 / YP18

Details:

Mass: 24482.357 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05748

#17: Protein

w CQ 60S ribosomal protein L16-A / Ribosome / L13a / L21 / Large ribosomal subunit protein uL13-A / RP22 / YL15

Details:

Mass: 22247.227 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P26784

#18: Protein

x CR 60S ribosomal protein L17-A / Ribosome / L20A / Large ribosomal subunit protein uL22-A / YL17

Details:

Mass: 20589.518 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05740

#19: Protein

y CS 60S ribosomal protein L18-A / Ribosome / Large ribosomal subunit protein eL18-A / RP28

Details:

Mass: 20609.252 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX49

#20: Protein

z CT 60S ribosomal protein L19-A / Ribosome / L23 / Large ribosomal subunit protein eL19-A / RP15L / RP33 / YL14

Details:

Mass: 21762.316 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX82

#21: Protein

0 CU 60S ribosomal protein L20-A / Ribosome / L18a / Large ribosomal subunit protein eL20-A

Details:

Mass: 20478.852 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX23

#22: Protein

2 CV 60S ribosomal protein L21-A / Ribosome / Large ribosomal subunit protein eL21-A

Details:

Mass: 18279.266 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: Q02753

#23: Protein

5 CW 60S ribosomal protein L22-A / Ribosome / L1c / Large ribosomal subunit protein eL22-A / RP4 / YL31

Details:

Mass: 13711.359 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05749

#24: Protein

6 CX 60S ribosomal protein L23-A / Ribosome / L17a / Large ribosomal subunit protein uL14-A / YL32

Details:

Mass: 14493.950 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX41

#25: Protein

7 CY 60S ribosomal protein L24-A / Ribosome / L30 / Large ribosomal subunit protein eL24-A / RP29 / YL21

Details:

Mass: 17661.717 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P04449

#26: Protein

8 CZ 60S ribosomal protein L25 / / Large ribosomal subunit protein uL23 / RP16L / YL25 / YP42'

Details:

Mass: 15787.612 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P04456

#27: Protein

9 DA 60S ribosomal protein L26-A / Ribosome / L33 / Large ribosomal subunit protein uL24-A / YL33

Details:

Mass: 14265.784 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05743

#28: Protein

AA DB 60S ribosomal protein L27-A / Ribosome / Large ribosomal subunit protein eL27-A

Details:

Mass: 15568.360 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0C2H6

#29: Protein

AB DC 60S ribosomal protein L28 / / L27a / L29 / Large ribosomal subunit protein uL15 / RP44 / RP62 / YL24

Details:

Mass: 16761.666 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P02406

#30: Protein

AC DD 60S ribosomal protein L29 / / Large ribosomal subunit protein eL29 / YL43

Details:

Mass: 6691.884 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05747

#31: Protein

AD DE 60S ribosomal protein L30 / / L32 / Large ribosomal subunit protein eL30 / RP73 / YL38

Details:

Mass: 11430.364 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P14120

#32: Protein

AE DF 60S ribosomal protein L31-A / Ribosome / L34 / Large ribosomal subunit protein eL31-A / YL28

Details:

Mass: 12980.158 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0C2H8

#33: Protein

AF DG 60S ribosomal protein L32 / / Large ribosomal subunit protein eL32

Details:

Mass: 14809.441 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P38061

#34: Protein

AG DH 60S ribosomal protein L33-A / Ribosome / L37 / Large ribosomal subunit protein eL33-A / RP47 / YL37

Details:

Mass: 12177.130 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05744

#35: Protein

AH DI 60S ribosomal protein L34-A / Ribosome / Large ribosomal subunit protein eL34-A

Details:

Mass: 13673.196 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P87262

#36: Protein

AI DJ 60S ribosomal protein L35-A / Ribosome / Large ribosomal subunit protein uL29-A

Details:

Mass: 13942.640 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX84

#37: Protein

AJ DK 60S ribosomal protein L36-A / Ribosome / L39 / Large ribosomal subunit protein eL36-A / YL39

Details:

Mass: 11151.259 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05745

#38: Protein

AK DL 60S ribosomal protein L37-A / Ribosome / L43 / Large ribosomal subunit protein eL37-A / YL35 / YP55

Details:

Mass: 9877.395 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P49166

#39: Protein

AL DM 60S ribosomal protein L38 / / Large ribosomal subunit protein eL38

Details:

Mass: 8845.561 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P49167

#40: Protein

AM DN 60S ribosomal protein L39 / / L46 / Large ribosomal subunit protein eL39 / YL40

Details:

Mass: 6358.640 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P04650

#42: Protein/peptide

AO DP 60S ribosomal protein L41-B / Ribosome / L47 / Large ribosomal subunit protein eL41-B / YL41

Details:

Mass: 3354.243 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX87

#43: Protein

AP DQ 60S ribosomal protein L42-A / Ribosome / L41 / Large ribosomal subunit protein eL42-A / YL27 / YP44

Details:

Mass: 12246.658 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX27

#44: Protein

AQ DR 60S ribosomal protein L43-A / Ribosome / L37a / Large ribosomal subunit protein eL43-A / YL35

Details:

Mass: 10112.952 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX25

Protein , 5 types, 9 molecules AN DO i sM p0 g e1 h Rb

#41: Protein

AN DO Ubiquitin-60S ribosomal protein L40

Details:

Mass: 14583.077 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CH08

#45: Protein

i sM Suppressor protein STM1 / 3BP1 / GU4 nucleic-binding protein 2 / G4p2 protein / POP2 multicopy suppressor protein 4 / Ribosomal subunits association factor / AF / TOM1 suppressor protein 1 / Triplex-binding protein 1

Details:

Mass: 30048.010 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P39015

#46: Protein

p0 60S acidic ribosomal protein P0 / / A0 / L10e / Large ribosomal subunit protein uL10

Details:

Mass: 33749.121 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05317

#79: Protein

g e1 Ubiquitin-40S ribosomal protein S31

Details:

Mass: 17254.227 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05759

#80: Protein

h Rb Guanine nucleotide-binding protein subunit beta-like protein / Receptor for activated C kinase / Receptor of activated protein kinase C 1 / RACK1 / Small ribosomal subunit protein RACK1

Details:

Mass: 34841.219 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P38011

18S ribosomal ... , 2 types, 2 molecules A sR

#47: RNA chain

A 18S ribosomal RNA /

Details:

Mass: 578820.375 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: GenBank: 1329886537

#81: RNA chain

sR 18S ribosomal RNA /

Details:

Mass: 579761.938 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: GenBank: 874346701

40S ribosomal protein ... , 31 types, 62 molecules B s0 C s1 D s2 E s3 F s4 G s5 H s6 I s7 J s8 K s9 L c0 M c1 N c2 O c3 P c4 ...

#48: Protein

B s0 40S ribosomal protein S0-A / Ribosome / Nucleic acid-binding protein NAB1A / Small ribosomal subunit protein uS2-A

Details:

Mass: 28051.330 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P32905

#49: Protein

C s1 40S ribosomal protein S1-A / Ribosome / RP10A / Small ribosomal subunit protein eS1-A

Details:

Mass: 28798.467 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P33442

#50: Protein

D s2 40S ribosomal protein S2 / / Omnipotent suppressor protein SUP44 / RP12 / S4 / Small ribosomal subunit protein uS5 / YS5

Details:

Mass: 27490.826 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P25443

#51: Protein

E s3 40S ribosomal protein S3 / / RP13 / Small ribosomal subunit protein uS3 / YS3

Details:

Mass: 26542.789 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05750

#52: Protein

F s4 40S ribosomal protein S4-A / Ribosome / RP5 / S7 / Small ribosomal subunit protein eS4-A / YS6

Details:

Mass: 29469.330 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX35

#53: Protein

G s5 40S ribosomal protein S5 / / RP14 / S2 / Small ribosomal subunit protein uS7 / YS8

Details:

Mass: 25072.600 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P26783

#54: Protein

H s6 40S ribosomal protein S6-A / Ribosome / RP9 / S10 / Small ribosomal subunit protein eS6-A / YS4

Details:

Mass: 27054.486 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX37

#55: Protein

I s7 40S ribosomal protein S7-A / Ribosome / RP30 / RP40 / Small ribosomal subunit protein eS7-A

Details:

Mass: 21658.209 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P26786

#56: Protein

J s8 40S ribosomal protein S8-A / Ribosome / RP19 / S14 / Small ribosomal subunit protein eS8-A / YS9

Details:

Mass: 22537.803 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX39

#57: Protein

K s9 40S ribosomal protein S9-A / Ribosome / RP21 / S13 / Small ribosomal subunit protein uS4-A / YP28 / YS11

Details:

Mass: 22487.893 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: O13516

#58: Protein

L c0 40S ribosomal protein S10-A / Ribosome / Small ribosomal subunit protein eS10-A

Details:

Mass: 12757.445 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: Q08745

#59: Protein

M c1 40S ribosomal protein S11-A / Ribosome / RP41 / S18 / Small ribosomal subunit protein uS17-A / YS12

Details:

Mass: 17785.934 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX47

#60: Protein

N c2 40S ribosomal protein S12 / / Small ribosomal subunit protein eS12

Details:

Mass: 15488.631 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P48589

#61: Protein

O c3 40S ribosomal protein S13 / / S27a / Small ribosomal subunit protein uS15 / YS15

Details:

Mass: 17059.945 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P05756

#62: Protein

P c4 40S ribosomal protein S14-B / Ribosome / RP59B / Small ribosomal subunit protein uS11-B

Details:

Mass: 14675.771 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P39516

#63: Protein

Q c5 40S ribosomal protein S15 / / RIG protein / RP52 / S21 / Small ribosomal subunit protein uS19 / YS21

Details:

Mass: 16031.907 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: Q01855

#64: Protein

R c6 40S ribosomal protein S16-A / Ribosome / RP61R / Small ribosomal subunit protein uS9-A

Details:

Mass: 15877.490 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX51

#65: Protein

S c7 40S ribosomal protein S17-A / Ribosome / RP51A / Small ribosomal subunit protein eS17-A

Details:

Mass: 15820.413 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P02407

#66: Protein

T c8 40S ribosomal protein S18-A / Ribosome / Small ribosomal subunit protein uS13-A

Details:

Mass: 17071.641 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX55

#67: Protein

U c9 40S ribosomal protein S19-A / Ribosome / RP55A / S16a / Small ribosomal subunit protein eS19-A / YP45 / YS16A

Details:

Mass: 15942.125 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P07280

#68: Protein

V d0 40S ribosomal protein S20 / / Small ribosomal subunit protein uS10

Details:

Mass: 13929.044 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P38701

#69: Protein

W d1 40S ribosomal protein S21-A / Ribosome / S26 / Small ribosomal subunit protein eS21-A / YS25

Details:

Mass: 9758.829 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0C0V8

#70: Protein

X d2 40S ribosomal protein S22-A / Ribosome / RP50 / S24 / Small ribosomal subunit protein uS8-A / YP58 / YS22

Details:

Mass: 14650.062 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0C0W1

#71: Protein

Y d3 40S ribosomal protein S23-A / Ribosome / RP37 / S28 / Small ribosomal subunit protein uS12-A / YS14

Details:

Mass: 16073.896 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX29

#72: Protein

Z d4 40S ribosomal protein S24-A / Ribosome / RP50 / Small ribosomal subunit protein eS24-A

Details:

Mass: 15362.848 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX31

#73: Protein

a d5 40S ribosomal protein S25-A / Ribosome / RP45 / S31 / Small ribosomal subunit protein eS25-A / YS23

Details:

Mass: 12067.272 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: Q3E792

#74: Protein

b d6 40S ribosomal protein S26-B / Ribosome / Small ribosomal subunit protein eS26-B

Details:

Mass: 13480.886 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P39939

#75: Protein

c d7 40S ribosomal protein S27-A / Ribosome / RP61 / Small ribosomal subunit protein eS27-A / YS20

Details:

Mass: 8893.391 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P35997

#76: Protein

d d8 40S ribosomal protein S28-A / Ribosome / S33 / Small ribosomal subunit protein eS28-A / YS27

Details:

Mass: 7605.847 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: Q3E7X9

#77: Protein

e d9 40S ribosomal protein S29-A / Ribosome / S36 / Small ribosomal subunit protein uS14-A / YS29

Details:

Mass: 6675.723 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P41057

#78: Protein

f e0 40S ribosomal protein S30-A / Ribosome / Small ribosomal subunit protein eS30-A

Details:

Mass: 7137.541 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Saccharomyces cerevisiae (brewer's yeast) / References: UniProt: P0CX33

Non-polymers , 5 types, 2586 molecules

#82: Chemical

1-3401 1-3402 1-3403 1-3404 1-3405 1-3406 1-3407 1-3408 1-3409 1-3410 1-3411 1-3412 1-3413 1-3414 1-3415 1-3416 1-3417 1-3418 1-3419 1-3420 ...
ChemComp-OHX / osmium (III) hexammine / osmium(6+) hexaazanide

Details:

Mass: 286.365 Da / Num. of mol.: 1057 / Source method: obtained synthetically / Formula: H₁₂N₆Os

#83: Chemical

1-3725 1-3726 1-3727 1-3728 1-3729 1-3730 1-3731 1-3732 1-3733 1-3734 1-3735 1-3736 1-3737 1-3738 1-3739 1-3740 1-3741 1-3742 1-3743 1-3744 ...
ChemComp-MG / MAGNESIUM ION

Details:

Mass: 24.305 Da / Num. of mol.: 1509 / Source method: obtained synthetically / Formula: Mg

#84: Chemical

1-4224 AR-4264 ChemComp-G5B / (3~{R})-3-[(1~{S})-2-[(1~{S},4~{a}~{R},6~{S},7~{S},8~{a}~{R})-6,7-bis(chloranyl)-5,5,8~{a}-trimethyl-2-methylidene-3,4,4~{a},6,7,8-hexahydro-1~{H}-naphthalen-1-yl]-1-oxidanyl-ethyl]pyrrolidine-2,5-dione

Details:

Mass: 402.355 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₂₀H₂₉Cl₂NO₃

#85: Chemical

AK-101 AN-500 AP-501 AQ-501 DL-101 DO-201 DQ-501 DR-501 b-201 c-101 e-101 g-501 d6-201 d7-101 d9-101 e1-501
ChemComp-ZN / ZINC ION

Details:

Mass: 65.409 Da / Num. of mol.: 16 / Source method: obtained synthetically / Formula: Zn

#86: Chemical

AR-4262 AR-4263 ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL / Glycerol

Details:

Mass: 92.094 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C₃H₈O₃

Experimental details

Experiment

• Experiment: Method: X-RAY DIFFRACTION / Number of used crystals: 1

Sample preparation

• Crystal: Density Matthews: 3.19 ų/Da / Density % sol: 61.38 %
• Crystal grow: Temperature: 277 K / Method: vapor diffusion, hanging drop / pH: 7 ; Details: PEG 20K, KSCN, Mg Acetate, Tris-Acetate, Glycerol, Spermidine

Data collection

• Diffraction: Mean temperature: 100 K
• Diffraction source: Source: SYNCHROTRON / Site: SOLEIL / Beamline: PROXIMA 1 / Wavelength: 1 Å
• Detector: Type: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Jun 20, 2017
• Radiation: Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
• Radiation wavelength: Wavelength: 1 Å / Relative weight: 1
• Reflection: Resolution: 3.1→55 Å / Num. obs: 1332963 / % possible obs: 100 % / Redundancy: 16.4 % / B_iso Wilson estimate: 67.044172739 Ų / CC_1/2: 0.992 / R_rim(I) all: 0.422 / Net I/σ(I): 7.65
• Reflection shell: Resolution: 3.1→3.2 Å / Mean I/σ(I) obs: 1.2 / CC_1/2: 0.504 / % possible all: 100

Processing

Software

Name	Version	Classification
PHENIX	dev_2450	refinement
PHENIX	dev_2450	refinement
XDS		data reduction
XSCALE		data scaling
PHENIX		phasing

Refinement

Resolution: 3.10000049683→54.7079019237 Å / SU ML: 0.417106379909 / Cross valid method: FREE R-VALUE / σ(F): 1.35503715987 / Phase error: 26.3598230588

	Rfactor	Num. reflection	% reflection
Rfree	0.26447041554	26492	1.98796654405 %
Rwork	0.216710978651	-	-
obs	0.217667239898	1332618	99.9821436074 %

• Solvent computation: Shrinkage radii: 0.8 Å / VDW probe radii: 1.1 Å
• Displacement parameters: B_iso mean: 60.3351349935 Ų

Refinement step

Cycle: LAST / Resolution: 3.10000049683→54.7079019237 Å

	Protein	Nucleic acid	Ligand	Solvent	Total
Num. atoms	178049	222470	8976	0	409495

Refine LS restraints

Refine-ID	Type	Dev ideal	Number
X-RAY DIFFRACTION	f_bond_d	0.0096981057589	436900
X-RAY DIFFRACTION	f_angle_d	1.35396564812	647650
X-RAY DIFFRACTION	f_chiral_restr	0.0586573145343	79249
X-RAY DIFFRACTION	f_plane_restr	0.00702264793968	41542
X-RAY DIFFRACTION	f_dihedral_angle_d	18.4789913846	236626

LS refinement shell

Resolution (Å)	Rfactor Rfree	Num. reflection Rfree	Rfactor Rwork	Num. reflection Rwork	Refine-ID	% reflection obs (%)
3.1-3.1352	0.349900646957	856	0.321745283791	43259	X-RAY DIFFRACTION	99.9705402466
3.1352-3.1721	0.339738513848	888	0.294347249009	43525	X-RAY DIFFRACTION	99.9864922668
3.1721-3.2108	0.326293375468	878	0.278208086061	43386	X-RAY DIFFRACTION	99.9909641276
3.2108-3.2514	0.326947533498	878	0.27183746205	43496	X-RAY DIFFRACTION	99.9887334099
3.2514-3.2942	0.305060219702	886	0.258214260655	43403	X-RAY DIFFRACTION	99.9841972187
3.2942-3.3393	0.305513441131	867	0.257477149212	43477	X-RAY DIFFRACTION	99.9977449543
3.3393-3.387	0.293534905501	905	0.2518099269	43437	X-RAY DIFFRACTION	99.995489807
3.387-3.4376	0.293452339226	847	0.249788284434	43436	X-RAY DIFFRACTION	99.9954837981
3.4376-3.4913	0.283195357288	875	0.234715455136	43473	X-RAY DIFFRACTION	99.9954904171
3.4913-3.5485	0.295097185509	891	0.226458269402	43449	X-RAY DIFFRACTION	100
3.5485-3.6097	0.273965391715	865	0.218109588442	43559	X-RAY DIFFRACTION	99.9909966688
3.6097-3.6753	0.261462949297	943	0.210582036536	43331	X-RAY DIFFRACTION	99.9954828801
3.6753-3.746	0.266808156341	933	0.213361616257	43548	X-RAY DIFFRACTION	99.9977518996
3.746-3.8224	0.262918032671	858	0.208708122397	43399	X-RAY DIFFRACTION	100
3.8224-3.9055	0.257612706711	911	0.201131623957	43484	X-RAY DIFFRACTION	99.9954951911
3.9055-3.9963	0.257105617666	871	0.198699573043	43541	X-RAY DIFFRACTION	100
3.9963-4.0962	0.25361733804	849	0.194976486179	43466	X-RAY DIFFRACTION	99.9977434787
4.0962-4.207	0.251309952513	908	0.193861019507	43487	X-RAY DIFFRACTION	100
4.207-4.3307	0.24692633583	849	0.194718800805	43562	X-RAY DIFFRACTION	99.9977483563
4.3307-4.4704	0.248347663889	893	0.190600727544	43506	X-RAY DIFFRACTION	100
4.4704-4.6301	0.248118913324	836	0.193908396381	43625	X-RAY DIFFRACTION	99.9977508884
4.6301-4.8154	0.241297146029	895	0.190954967084	43578	X-RAY DIFFRACTION	100
4.8154-5.0344	0.257651008904	886	0.197419705267	43548	X-RAY DIFFRACTION	100
5.0344-5.2996	0.24277386643	873	0.195385546332	43574	X-RAY DIFFRACTION	100
5.2996-5.6314	0.250359042818	882	0.19772826469	43636	X-RAY DIFFRACTION	100
5.6314-6.0657	0.241719198159	898	0.202072393008	43658	X-RAY DIFFRACTION	99.9977556837
6.0657-6.6751	0.25448491045	894	0.210957342723	43626	X-RAY DIFFRACTION	99.997753869
6.6751-7.6388	0.262528371699	894	0.220111222908	43744	X-RAY DIFFRACTION	99.9977598064
7.6388-9.6155	0.269598566614	873	0.230423239273	43853	X-RAY DIFFRACTION	99.997764214
9.6155-54.7164	0.247752751463	910	0.235276239041	44060	X-RAY DIFFRACTION	99.603534962

Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

ID	L11 (°2)	L12 (°2)	L13 (°2)	L22 (°2)	L23 (°2)	L33 (°2)	S11 (Å °)	S12 (Å °)	S13 (Å °)	S21 (Å °)	S22 (Å °)	S23 (Å °)	S31 (Å °)	S32 (Å °)	S33 (Å °)	T11 (Å2)	T12 (Å2)	T13 (Å2)	T22 (Å2)	T23 (Å2)	T33 (Å2)	Origin x (Å)	Origin y (Å)	Origin z (Å)
1	0.167246266891	0.0232542765463	-0.0578645604407	0.112740989405	0.0124190029508	0.188191587417	-0.00735865456674	0.0285327570741	-0.0280856404255	0.00682198633932	-0.0329444192822	-0.0255731486791	0.0248373523741	-0.0157819974907	0.0215759395472	0.144568994857	-0.00537103831481	-0.0103524662329	0.140950440857	0.0484234815086	0.180359311353	68.3133070021	-1.58221816961	47.8292812118
2	0.0734180871419	0.0436951282538	0.0970300827775	0.245478606887	-0.11997277491	0.1918546852	-0.0374722054907	0.0859713309195	0.179836662683	-0.0411215427559	0.0581179231303	0.216619959653	-0.219972700018	-0.265489868279	-0.0704589858159	0.384471116594	0.23057438809	-0.0378831762495	0.543651575973	0.158930186551	0.445002415747	12.7876386991	67.1049871416	26.0491514575
3	0.206293758058	0.0497720153423	-0.0481444363074	0.0940744981796	0.00910143340232	0.158044957953	-0.0130092733338	-0.124980322047	-0.0681404284077	0.062854981463	-0.0144278045046	-0.160838304141	0.0378182826942	0.172206431575	0.0272941389293	0.249989690932	0.0348138868568	-0.0588451739783	0.389250257696	0.105381192482	0.409749087973	114.965002268	-7.29287620981	82.2979584555
4	0.165739645888	0.0464029569498	-0.0935671689439	0.114288643303	0.0750457760233	0.14654260226	0.0164900529765	0.0681521917817	0.129185490972	-0.0999381556479	-0.0443226641632	-0.119984142666	-0.0499161720257	0.132132453188	0.00482799792911	0.19408938942	-0.0121486883997	0.0757740102917	0.267597241279	0.111570149096	0.358710771903	123.164590097	4.3133802338	16.5949383945
5	0.141408858836	0.0745610956264	0.0537245288715	0.12160762073	-0.01115147161	0.0373239406573	-0.0403583165751	0.0542390977797	-0.142381050378	0.036386772481	-0.0341652313992	-0.0503448174175	0.155872323284	-0.103311203896	-0.041548868602	0.343894107489	-0.19926324778	0.128537494829	0.241685466288	-0.132026290727	0.313409563692	33.4439479164	-61.1129460779	37.640178513
6	0.261401412948	0.00997421003712	-0.0585669543179	0.243868703972	-0.0182100229452	0.10491076716	0.0563383447878	-0.114134079275	-0.012786604511	0.175737948442	-0.0573503220591	-0.0540935948957	-0.030058715319	-0.0241295324723	-0.0102188985841	0.225034769483	-0.0379237697639	0.00397445771564	0.227242157022	0.000700117072304	0.111343414031	57.9419972349	24.897224821	102.680315147
7	0.00861174395947	0.0220990285352	-0.0298711873735	0.234929640886	-0.0154646991079	0.103540867497	-0.082130773597	0.0884982791266	0.24537306546	-0.0763784865323	-0.00720869000141	0.120107656474	-0.170709019937	-0.0816694325443	-0.0260830490336	0.533233197229	0.228875476034	-0.0745928384541	0.323929814839	0.169924329004	0.556753806016	25.9999113966	93.4286088964	28.6849843621
8	0.108981070142	-0.00767778098981	0.0271238744603	0.266384376654	-0.110103407654	0.0496075389571	0.04563790324	-0.0771897509541	-0.00606421581791	0.219914154595	-0.0707373267596	0.0327532098916	-0.139498316834	0.0604438246189	0.0160086461572	0.255375492755	-0.0978362397561	0.0863735172106	0.323081831703	-0.048268094332	0.194048439148	-4.21276219204	-12.1139204825	106.185779296
9	0.209786665275	-0.0432946022168	0.0384973625464	0.555463827595	-0.00192212805547	0.0903392729762	0.0370971232448	-0.0102170242038	0.130285842974	0.0933690011817	0.0222245012857	0.0232975970624	-0.0217209445822	-0.0896105089389	-0.0177290499586	0.106018272856	0.0617865240474	-0.00675582902357	0.29410075547	-0.00716107013876	0.210139461163	4.76835335818	31.4133431211	77.1960143675
10	0.324976635291	-0.0720919257075	0.0168692653326	0.527165411057	0.158325938265	0.267095685518	0.0896935563529	-0.0221752384118	0.0465776400409	-0.0615902520727	0.0321940715655	-0.338533590878	-0.121359891251	0.246938909727	-0.104539755248	0.214743552703	-0.167003078655	0.00945359793651	0.513019205311	0.0853283542271	0.528272223215	154.499284552	40.213510404	53.4050270051
11	0.00908591700167	-0.0291949573353	0.00932489788056	0.0850161476817	-0.0203398382251	0.00599048893747	-0.0298747023721	0.111992329843	-0.151991930923	-0.0645204300973	-0.0048836755435	0.0973068807426	0.118094515761	-0.131658466513	0.0504089408495	0.324694966686	-0.215216811082	0.0221249128334	0.664357202642	-0.205061300045	0.332325794934	-11.7354661389	-33.0784135763	18.6597465753
12	0.275396794386	0.101556961816	0.0122227422111	0.232576965506	0.0395730195937	0.579008494225	0.0421166846963	0.172278387268	0.0775135572606	-0.115537198303	0.0193415115982	0.080923875079	-0.107976837259	-0.109798322694	0.0299586361904	0.23173766675	0.0419314662266	-0.0830155212155	0.474920941605	0.0927473738665	0.181307362395	10.4656748628	27.2101392891	13.1214469247
13	0.137513875516	0.113085542906	-0.112502679937	0.225721876116	0.019639522225	0.189203144722	-0.140044724221	0.210733170141	0.118949949502	-0.267623444873	0.0415467794603	0.0595494526823	-0.122593062283	0.047126365178	0.0184932264337	0.748651511005	0.145314418959	-0.047528292173	0.731106329453	0.281524856	0.404039092565	31.2525366086	78.9819467268	-7.80328932735
14	0.130526548366	0.0810193913003	0.0324831631395	0.148708275508	0.0537991001477	0.019606090411	0.0280288914272	-0.0485471056867	0.089325921608	0.0455390862722	0.00761834063116	-0.0888035193536	-0.0913234139602	0.0735082724872	0.0830865075626	0.243198801427	-0.177611728464	-0.0673735395932	0.278931627289	0.00291495972271	0.281777734594	98.8962836765	55.3104722042	87.6829119411
15	0.161204458658	0.116578078934	0.0468332934864	0.0964646911979	-0.0669533401251	0.592287025209	-0.0199651885047	0.0398318774696	-0.0159885134367	-0.022221456621	-0.020622310772	0.0824455389624	0.131683684591	-0.181656439389	0.0433548740479	0.154877363244	-0.0707970898952	0.0163704547909	0.435203925226	-0.0104671804342	0.286270910912	-26.1689136059	-14.2293903331	64.8619485069
16	0.140992393599	-0.0200592603582	-0.0193502147359	0.0443780875194	0.0558705256626	0.0666677200141	0.00481347015461	-0.0141530014964	0.0634255752168	-0.0131039722139	0.0271753450916	-0.0994791370061	-0.0755766691375	0.0873799980755	-0.0684388624598	0.176363454002	-0.13918518345	-0.0346367168605	0.323038864845	0.088637697792	0.355329279198	119.292551888	32.4487545423	61.6358720772
17	0.0617639290953	-0.0358001693329	0.00622232627226	0.14991107651	0.0460609437963	0.0363523284473	-0.0644758959124	0.0979206130644	0.0209983636092	0.0414477209298	0.0147538085907	0.00239561330605	0.0957095763577	-0.126994376092	0.0278747393571	0.224076466049	-0.153145350003	0.0504382640159	0.353344635155	-0.104991565571	0.247454192013	3.50391748145	-30.043402646	56.9815908728
18	0.294178121407	0.060292549377	0.310837452833	0.454840888696	-0.0363263060729	0.352766180585	-0.0461163458653	-0.092280335805	0.0920232159825	0.166742329997	-0.0153807931925	0.107500953754	-0.00244253958162	-0.178013802992	-0.0455721800657	0.293366051016	4.87978444566E-5	0.0509164776281	0.183270526628	0.0771397088623	0.293756252639	55.6318672605	-40.2904260788	82.7117980229
19	0.151975290411	-0.0414470715815	0.000850640621861	0.19747052805	-0.0484509551599	0.250372216771	0.0552013810571	-0.0372838157017	0.0520353463949	0.0653922520586	-0.0483247216346	-0.0497642071225	-0.0914120752354	0.0159079324958	-0.0154540099751	0.283382212144	-0.0343853433349	0.0464987822731	0.182707944546	-0.0244652097042	0.242170451996	51.9661116214	50.0449569334	89.8837512202
20	0.233026933984	-0.0265622896127	0.03862133058	0.210200825895	0.0533487427595	0.0231131697273	-0.0766839531014	0.139576561337	-0.13049462937	-0.0539355868081	-0.0300296797666	-0.107774764266	0.176198912042	0.0568173265067	0.0671424692127	0.361423910439	0.148921080173	0.139561336512	0.364732874719	0.0109377720251	0.499643009299	121.771257528	-57.6181321836	10.68305918
21	0.222040155816	0.0457662120957	-0.16040458033	0.349928495856	-0.24939590375	0.246753873209	-0.0264502355003	0.151806670555	0.0451054153345	-0.110423523194	-0.000919656196654	0.0858443347494	0.0565394987915	-0.195795257911	0.0181872179229	0.136932026885	0.0280908663043	-0.0431484520746	0.459155411695	-0.0125364960671	0.252334666434	-12.3487429184	14.2510414674	47.1868940863
22	0.242270333041	0.156506586716	0.0225361428836	0.15647951195	-0.089491721939	0.188217643647	-0.00147327114151	0.0265058150168	0.198229128904	-0.0209588256558	0.0079808277376	0.138896713529	-0.0666439228122	-0.145452282315	0.026076156222	0.232033885239	0.151238702797	-0.0257328643063	0.271162343813	0.0377776707498	0.302293014936	21.779341786	55.1010221746	50.0627297797
23	0.328807432549	-0.0121377239615	0.169006711129	0.298562715688	0.0503845125702	0.0974550182695	0.0298602866721	-0.0119308931904	-0.238398453063	0.0644142373689	0.0106570429748	-0.00207267213687	0.104660156131	0.013553972022	-0.0239869674648	0.76524207549	0.263844102472	-0.00357084400264	0.446907979863	-0.0189621186698	1.08036124685	113.653757333	-89.4381423075	42.1290830675
24	0.0679573108977	-0.0576516123051	0.0229324020248	0.395684421538	0.0259520387051	0.123535399671	-0.0158850521581	0.122813351784	-0.120274746067	-0.170732717252	-0.0793858803377	0.185494274823	0.0628984430508	-0.183505842386	0.105431473548	0.324089712779	-0.0504372870043	0.0740225415086	0.336223989452	-0.138978577415	0.267025830209	49.1012646963	-45.3291096693	-0.238010932668
25	0.149347256596	0.00598945455849	0.14633689394	0.442828421142	0.0581286607802	0.149101921427	0.0430477339216	0.34578887043	-0.524462618887	-0.140916248122	0.0166828728867	0.1575571506	0.5769173962	-0.159830578925	-0.161673728782	0.725287085341	-0.116838197399	0.134898729537	0.410242748181	-0.17239848424	0.598658560922	57.3127180019	-81.0461571389	3.67779465731
26	0.127149338699	-0.0773791573159	0.0671728073867	0.316219817748	0.133872017888	0.147771594017	-0.00492922561907	-0.00412990852398	0.0306003321767	0.020509903782	-0.0130223605396	-0.235342833496	0.0130193507232	0.0971805428936	0.0341295335109	0.278856275862	0.121130484183	-0.0262941741367	0.442556876192	0.156055165462	0.446974739381	133.421175092	-24.5672663016	74.0236984286
27	0.134223372168	-0.117353585157	-0.0107457164166	0.123067836003	-0.0281293766096	0.204885180469	-0.1127999827	-0.178039439035	-0.00421331095542	0.170895703982	0.031399650734	-0.137902675456	0.0461956372888	0.141313992138	0.0272007359687	0.3434330219	-0.0161775618199	-0.11193344812	0.490095701791	0.12817856409	0.264060429744	96.8796189217	-11.3726596805	117.280087559
28	0.28543860533	0.0477259160053	0.100017949786	0.0154535727818	0.00798807310499	0.0444429288324	-0.0298459533842	0.0195729951309	-0.0261753489167	0.0115208114984	0.103736584247	-0.15482543176	0.0423217897855	0.176730359141	-0.0495463838861	0.281448581819	0.151909835783	0.15415074907	0.698383297393	-0.0235395154289	0.710296489534	172.826690407	-27.0190075926	19.4608862007
29	0.248783874447	0.0682621025839	-0.0343956712862	0.108356434535	-0.083961518227	0.080375855798	0.0395938020853	-0.119329611904	0.0861490814054	0.0590120140423	-0.0402138389573	-0.00857162519974	-0.137340484975	-0.0187177815476	-0.00253161347216	0.278167305068	-0.0775247990691	-0.0113751263105	0.226161212126	0.00932561653249	0.186521440875	72.3043779143	54.364278431	78.6424675803
30	0.323134112454	0.114747054166	-0.006312299847	0.624741911532	-0.105715681487	0.0548256471892	0.0337606682968	-0.00521758543983	0.0635527076609	0.231716574273	-0.0326260833288	0.0581392876352	-0.156612058098	-0.0537415567251	0.00382063529653	0.356554581317	0.0542868767434	-0.0382736042597	0.297226705869	0.100881325927	0.290938012389	41.7577030892	56.4401355653	63.2039551249
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140	0.344879215426	-0.138237525955	-0.133403565222	0.386417257482	-0.0315895715707	0.0727575735687	-0.0504054217383	-0.126632513466	0.289909282426	0.195064549526	0.162032241855	0.211692660544	-0.0530992061021	0.0143887583927	-0.034260074549	0.75703360091	-0.0789199944123	0.171743356954	0.359746473761	-0.190332066613	0.862274758058	206.115850044	71.0113800942	309.183495381
141	0.120849183261	0.0486296322987	-0.00487427781391	0.145925509958	-0.0619851344788	0.0547609401468	-0.0462949306793	-0.0964542356251	-0.055771846979	0.230707854989	-0.142536408497	0.271056339845	-0.0830038233187	-0.158955555404	0.159646630591	0.889762915755	-0.170912828424	0.234271956977	0.64368512294	-0.277279949716	0.606284801393	181.843524825	25.5231700134	325.863738683
142	0.180257247123	0.23263451994	0.00827188495508	0.298875664526	0.020112697022	0.259686182903	-0.107026907327	0.308752717755	0.294712451344	-0.180744142567	0.113412592743	0.239618922422	-0.00827227266877	-0.159930931159	-0.0342160840307	0.613827763659	-0.320596846663	0.0375419358904	0.645667902466	0.192667267591	0.802832534711	230.879951505	80.9064561082	259.998719003
143	0.208973927473	0.097774096483	0.010012816244	0.286521709056	-0.0774835148956	0.235316974771	0.0104097044821	-0.0677513911987	0.420087710458	0.0675771328309	0.069377708924	0.0712869358277	-0.21849230403	-0.0391803464147	-0.05170498758	0.643447206893	-0.0862149379051	0.0599480781252	0.362285864006	-0.113043663331	1.00263414194	227.97115571	87.7137818014	293.182491642
144	0.479454967494	-0.119485201114	0.133741119793	0.263279442105	-0.12268766659	0.0713639341808	-0.0466505564521	-0.11545648606	-0.015570988926	0.0885361836794	-0.106277751219	-0.212430014416	0.127792244276	0.228328348502	0.0775502846802	0.90691616313	0.313367481752	0.142657437913	0.989247528165	0.250943811165	1.22361365294	264.818006652	27.066436671	301.257559953
145	0.573553317794	-0.0865685205678	-0.0529191220209	0.490592940669	-0.0621537006976	0.314625139364	-0.11523680104	-0.302677941121	0.0103267973429	0.292559563488	-0.00112027821964	-0.228291608587	-0.133446450101	0.203027182116	0.120478850066	0.809742747439	-0.0384212684228	-0.055727165966	0.64975971317	-0.0496879147126	0.685543855269	236.490569495	50.2697889953	320.667241982
146	0.291489641726	0.0384997313965	0.0558621861176	0.0525632078084	0.0901722115919	0.224668771201	0.0968411389766	-0.262108071585	0.0803497938603	0.224125195666	0.0402089217387	0.0608781740031	-0.0427806850065	-0.113454958534	-0.0787933926953	0.892779788996	-0.218038855687	0.161806222778	0.503405168139	-0.0519863361434	0.30344458639	177.184555972	-18.9423010016	323.235797762
147	0.188569755579	0.075836233467	0.0216424888367	0.132972937294	-0.0540402865552	0.229605988078	-0.000142240903777	-0.174352991888	-0.0736254345957	0.250501941364	-0.0658623915002	0.0102356423142	-0.0263364298602	0.0165224609998	0.0278045932834	0.583130623281	-0.147668074402	0.119110803209	0.299791970692	0.0431519872669	0.268039259303	174.838931991	-38.9451523825	301.419248173
148	0.296187147266	0.126557323823	0.0118451541154	0.18827440554	-0.00355994880085	0.14089857255	0.1094805345	-0.00157465403589	-0.0553106604984	0.191216447078	-0.0506896123937	-0.0492669678906	-0.0393476409169	0.0088780820592	-0.0444549090391	0.311582912301	-0.0898796662405	-0.031161858372	0.177551040493	0.0410672432343	0.35715844184	218.708023803	-27.6235251548	263.968921107
149	0.176066185718	-0.0896203688056	0.141065568489	0.146204873002	-0.0844295488116	0.174254354613	0.0183491007569	-0.0202586348439	-0.0291669168604	0.141754076042	-0.0583044892843	-0.13138581106	0.0163846720596	0.121138920853	0.104469407951	0.650004386727	0.104080303983	-0.269533058105	0.354777179379	0.115020877173	0.608782981355	239.301619526	-85.3613074117	279.563559975
150	0.100083754463	-0.0454877296638	0.0651276661762	0.0889213105679	-0.0509109040757	0.0488619267844	0.0325775027242	0.0977795629314	0.128438303734	-0.114509177019	-0.0798552128236	0.0247265363945	-0.20222220118	-0.067678878836	0.0344234287222	0.776793679895	-0.00329729821735	0.0837986778493	0.589318306106	0.238140482776	1.31453122353	198.921636926	94.1004478666	273.556405942
151	0.244930381839	0.0376950026489	0.0202602152758	0.00580977631294	0.00467250173159	0.172643039292	0.0210266706925	-0.212621669052	0.163381197794	0.231063105862	0.063774898771	0.0129938886408	-0.232238747396	-0.141248236752	-0.0568304523577	0.728463726029	0.0287522975157	0.12740792997	0.438406281232	-0.103930600708	0.393684801277	168.07504514	18.6333452404	275.646768998
152	0.0215523203452	-0.109095865521	-0.00641261053691	0.557435602282	0.0972215047984	0.389344534848	0.0378498082116	0.0063025292203	-0.085366471102	0.0998656888786	-0.0498654073768	0.276078507395	-0.0573236568896	-0.38279207823	0.012760416879	0.508881816316	-0.0317553019205	0.309261809743	0.70445902926	-0.0356925241639	0.483449029678	135.577322355	-21.1173022851	295.053462293
153	0.278156534963	0.0563426445155	0.0139276049442	0.0116204461434	-0.00346036933335	0.145690873956	0.0174811861465	0.0175482512606	0.0144027484824	-0.0794443177815	-0.00236318294393	0.182904681044	-0.0160240161093	-0.180665842005	-0.00323121825459	0.659841011493	-0.239342785097	0.132329904545	0.95011960821	0.145441639366	1.20131545079	172.095098696	50.0791941775	288.164114655
154	0.20709230988	0.187262121034	-0.0439763978896	0.484943343328	-0.139815757249	0.470264472059	-0.000539234659021	-0.0115176552423	0.0155152868501	-0.0236638896107	-0.066604525437	-0.130222541144	0.129109787125	0.174968186416	0.0720336682011	0.559932368093	-0.0318246134193	0.00733964810937	0.439680885954	-0.0668362248371	0.826016260413	242.505849625	40.2454703519	292.842598064
155	0.0640124108943	-0.00212480300092	-0.0640550384157	0.192172113114	-0.20854739252	0.419627102015	0.106862458004	-0.0783357483601	0.0628359110805	0.225917864524	0.116991708179	-0.126811074439	-0.0907690441036	0.0935928146524	-0.174049438183	0.595564484902	-0.1807060375	-0.163700304419	0.457205854658	0.0210445969595	0.599220869258	239.248592479	-20.8680134566	289.409466072
156	0.0399765209283	0.0229094290283	0.0351223339174	0.0426976782697	-0.0339406516678	0.128733384284	-0.00965711663904	-0.0784718470166	-0.0882416662138	0.10759604789	-0.000264685417946	-0.0633834375461	0.0823742074802	0.0605950736807	0.00365951995104	1.28319561123	0.16388576492	0.138912473214	1.69779486381	0.267506647421	1.64512619342	294.833359833	39.3921894565	278.930823943
157	0.163805063906	0.00719903244682	0.0178156442849	0.260514430528	0.110095514906	0.160452690094	0.0725473442854	-0.0794081246993	-0.0257981796813	0.154816461915	-0.0572358454298	-0.029464864906	0.0559093510871	-0.0142854042528	-0.0185259017336	0.385999692986	-0.0999421446864	0.0104746961757	0.221215955208	0.0529472460217	0.257366585683	201.85091516	-25.5446972338	274.289270282
158	0.363511853312	0.21637182993	0.0599455098155	0.456186086258	-0.167850690603	0.705000139176	0.0872734034248	0.0192351392971	-0.0830995188816	0.0884319323572	0.0705819876497	-0.270293614235	0.251235050623	0.308724112084	-0.156324069783	0.614740598054	0.00659595948534	-0.132753043396	0.657285578877	0.158437930894	1.12167561695	324.774913079	-15.3282311976	187.095508614

Refinement TLS group

ID	Refine-ID	Refine TLS-ID	Selection details
1	X-RAY DIFFRACTION	1	chain 1
2	X-RAY DIFFRACTION	2	chain 3
3	X-RAY DIFFRACTION	3	chain 4
4	X-RAY DIFFRACTION	4	chain j
5	X-RAY DIFFRACTION	5	chain k
6	X-RAY DIFFRACTION	6	chain l
7	X-RAY DIFFRACTION	7	chain m
8	X-RAY DIFFRACTION	8	chain n
9	X-RAY DIFFRACTION	9	chain o
10	X-RAY DIFFRACTION	10	chain p
11	X-RAY DIFFRACTION	11	chain q
12	X-RAY DIFFRACTION	12	chain r
13	X-RAY DIFFRACTION	13	chain s
14	X-RAY DIFFRACTION	14	chain t
15	X-RAY DIFFRACTION	15	chain u
16	X-RAY DIFFRACTION	16	chain v
17	X-RAY DIFFRACTION	17	chain w
18	X-RAY DIFFRACTION	18	chain x
19	X-RAY DIFFRACTION	19	chain y
20	X-RAY DIFFRACTION	20	chain z
21	X-RAY DIFFRACTION	21	chain 0
22	X-RAY DIFFRACTION	22	chain 2
23	X-RAY DIFFRACTION	23	chain 5
24	X-RAY DIFFRACTION	24	chain 6
25	X-RAY DIFFRACTION	25	chain 7
26	X-RAY DIFFRACTION	26	chain 8
27	X-RAY DIFFRACTION	27	chain 9
28	X-RAY DIFFRACTION	28	chain AA
29	X-RAY DIFFRACTION	29	chain AB
30	X-RAY DIFFRACTION	30	chain AC
31	X-RAY DIFFRACTION	31	chain AD
32	X-RAY DIFFRACTION	32	chain AE
33	X-RAY DIFFRACTION	33	chain AF
34	X-RAY DIFFRACTION	34	chain AG
35	X-RAY DIFFRACTION	35	chain AH
36	X-RAY DIFFRACTION	36	chain AI
37	X-RAY DIFFRACTION	37	chain AJ
38	X-RAY DIFFRACTION	38	chain AK
39	X-RAY DIFFRACTION	39	chain AL
40	X-RAY DIFFRACTION	40	chain AM
41	X-RAY DIFFRACTION	41	chain AN
42	X-RAY DIFFRACTION	42	chain AO
43	X-RAY DIFFRACTION	43	chain AP
44	X-RAY DIFFRACTION	44	chain AQ
45	X-RAY DIFFRACTION	45	chain i
46	X-RAY DIFFRACTION	46	chain AR
47	X-RAY DIFFRACTION	47	chain AS
48	X-RAY DIFFRACTION	48	chain AT
49	X-RAY DIFFRACTION	49	chain CD
50	X-RAY DIFFRACTION	50	chain CE
51	X-RAY DIFFRACTION	51	chain CF
52	X-RAY DIFFRACTION	52	chain CG
53	X-RAY DIFFRACTION	53	chain CH
54	X-RAY DIFFRACTION	54	chain CI
55	X-RAY DIFFRACTION	55	chain CJ
56	X-RAY DIFFRACTION	56	chain CK
57	X-RAY DIFFRACTION	57	chain CL
58	X-RAY DIFFRACTION	58	chain CM
59	X-RAY DIFFRACTION	59	chain CN
60	X-RAY DIFFRACTION	60	chain CO
61	X-RAY DIFFRACTION	61	chain CP
62	X-RAY DIFFRACTION	62	chain CQ
63	X-RAY DIFFRACTION	63	chain CR
64	X-RAY DIFFRACTION	64	chain CS
65	X-RAY DIFFRACTION	65	chain CT
66	X-RAY DIFFRACTION	66	chain CU
67	X-RAY DIFFRACTION	67	chain CV
68	X-RAY DIFFRACTION	68	chain CW
69	X-RAY DIFFRACTION	69	chain CX
70	X-RAY DIFFRACTION	70	chain CY
71	X-RAY DIFFRACTION	71	chain CZ
72	X-RAY DIFFRACTION	72	chain DA
73	X-RAY DIFFRACTION	73	chain DB
74	X-RAY DIFFRACTION	74	chain DC
75	X-RAY DIFFRACTION	75	chain DD
76	X-RAY DIFFRACTION	76	chain DE
77	X-RAY DIFFRACTION	77	chain DF
78	X-RAY DIFFRACTION	78	chain DG
79	X-RAY DIFFRACTION	79	chain DH
80	X-RAY DIFFRACTION	80	chain DI
81	X-RAY DIFFRACTION	81	chain DJ
82	X-RAY DIFFRACTION	82	chain DK
83	X-RAY DIFFRACTION	83	chain DL
84	X-RAY DIFFRACTION	84	chain DM
85	X-RAY DIFFRACTION	85	chain DN
86	X-RAY DIFFRACTION	86	chain DO
87	X-RAY DIFFRACTION	87	chain DP
88	X-RAY DIFFRACTION	88	chain DQ
89	X-RAY DIFFRACTION	89	chain DR
90	X-RAY DIFFRACTION	90	chain sM
91	X-RAY DIFFRACTION	91	chain A
92	X-RAY DIFFRACTION	92	chain B
93	X-RAY DIFFRACTION	93	chain C
94	X-RAY DIFFRACTION	94	chain D
95	X-RAY DIFFRACTION	95	chain E
96	X-RAY DIFFRACTION	96	chain F
97	X-RAY DIFFRACTION	97	chain G
98	X-RAY DIFFRACTION	98	chain H
99	X-RAY DIFFRACTION	99	chain I
100	X-RAY DIFFRACTION	100	chain J
101	X-RAY DIFFRACTION	101	chain K
102	X-RAY DIFFRACTION	102	chain L
103	X-RAY DIFFRACTION	103	chain M
104	X-RAY DIFFRACTION	104	chain N
105	X-RAY DIFFRACTION	105	chain O
106	X-RAY DIFFRACTION	106	chain P
107	X-RAY DIFFRACTION	107	chain Q
108	X-RAY DIFFRACTION	108	chain R
109	X-RAY DIFFRACTION	109	chain S
110	X-RAY DIFFRACTION	110	chain T
111	X-RAY DIFFRACTION	111	chain U
112	X-RAY DIFFRACTION	112	chain V
113	X-RAY DIFFRACTION	113	chain W
114	X-RAY DIFFRACTION	114	chain X
115	X-RAY DIFFRACTION	115	chain Y
116	X-RAY DIFFRACTION	116	chain Z
117	X-RAY DIFFRACTION	117	chain a
118	X-RAY DIFFRACTION	118	chain b
119	X-RAY DIFFRACTION	119	chain c
120	X-RAY DIFFRACTION	120	chain d
121	X-RAY DIFFRACTION	121	chain e
122	X-RAY DIFFRACTION	122	chain f
123	X-RAY DIFFRACTION	123	chain g
124	X-RAY DIFFRACTION	124	chain h
125	X-RAY DIFFRACTION	125	chain s0
126	X-RAY DIFFRACTION	126	chain s1
127	X-RAY DIFFRACTION	127	chain s2
128	X-RAY DIFFRACTION	128	chain s3
129	X-RAY DIFFRACTION	129	chain s4
130	X-RAY DIFFRACTION	130	chain s5
131	X-RAY DIFFRACTION	131	chain s6
132	X-RAY DIFFRACTION	132	chain s7
133	X-RAY DIFFRACTION	133	chain s8
134	X-RAY DIFFRACTION	134	chain s9
135	X-RAY DIFFRACTION	135	chain c1
136	X-RAY DIFFRACTION	136	chain c2
137	X-RAY DIFFRACTION	137	chain c3
138	X-RAY DIFFRACTION	138	chain c4
139	X-RAY DIFFRACTION	139	chain c5
140	X-RAY DIFFRACTION	140	chain c6
141	X-RAY DIFFRACTION	141	chain c7
142	X-RAY DIFFRACTION	142	chain c8
143	X-RAY DIFFRACTION	143	chain c9
144	X-RAY DIFFRACTION	144	chain c0
145	X-RAY DIFFRACTION	145	chain d0
146	X-RAY DIFFRACTION	146	chain d1
147	X-RAY DIFFRACTION	147	chain d2
148	X-RAY DIFFRACTION	148	chain d3
149	X-RAY DIFFRACTION	149	chain d4
150	X-RAY DIFFRACTION	150	chain d5
151	X-RAY DIFFRACTION	151	chain d6
152	X-RAY DIFFRACTION	152	chain d7
153	X-RAY DIFFRACTION	153	chain d8
154	X-RAY DIFFRACTION	154	chain d9
155	X-RAY DIFFRACTION	155	chain e0
156	X-RAY DIFFRACTION	156	chain e1
157	X-RAY DIFFRACTION	157	chain sR
158	X-RAY DIFFRACTION	158	chain p0