+Open data
-Basic information
Entry | Database: PDB / ID: 6ecj | |||||||||
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Title | Human cytochrome c G41T | |||||||||
Components | Cytochrome c | |||||||||
Keywords | APOPTOSIS / cytochrome c / heme / glycine to threonine substitution | |||||||||
Function / homology | Function and homology information Formation of apoptosome / apoptosome / activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / Release of apoptotic factors from the mitochondria / Respiratory electron transport / cellular respiration / Regulation of the apoptosome activity / Activation of caspases through apoptosome-mediated cleavage / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes ...Formation of apoptosome / apoptosome / activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c / Release of apoptotic factors from the mitochondria / Respiratory electron transport / cellular respiration / Regulation of the apoptosome activity / Activation of caspases through apoptosome-mediated cleavage / SMAC (DIABLO) binds to IAPs / SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes / mitochondrial electron transport, cytochrome c to oxygen / mitochondrial electron transport, ubiquinol to cytochrome c / Detoxification of Reactive Oxygen Species / Pyroptosis / respirasome / intrinsic apoptotic signaling pathway / TP53 Regulates Metabolic Genes / Transcriptional activation of mitochondrial biogenesis / mitochondrial intermembrane space / Cytoprotection by HMOX1 / mitochondrial inner membrane / electron transfer activity / heme binding / mitochondrion / metal ion binding / nucleus / cytosol Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.7 Å | |||||||||
Model details | G41T variant | |||||||||
Authors | Fellner, M. / Jameson, G.N.L. / Ledgerwood, E.C. / Wilbanks, S.M. | |||||||||
Citation | Journal: Biochem.J. / Year: 2021 Title: Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity. Authors: Fellner, M. / Parakra, R. / McDonald, K.O. / Kass, I. / Jameson, G.N.L. / Wilbanks, S.M. / Ledgerwood, E.C. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6ecj.cif.gz | 182.7 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6ecj.ent.gz | 144.8 KB | Display | PDB format |
PDBx/mmJSON format | 6ecj.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ec/6ecj ftp://data.pdbj.org/pub/pdb/validation_reports/ec/6ecj | HTTPS FTP |
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-Related structure data
Related structure data | 5exqC 3nwvS S: Starting model for refinement C: citing same article (ref.) |
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Similar structure data |
-Links
-Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments:
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