Entry Database : PDB / ID : 5ufu Structure visualization Downloads & linksTitle Structure of AMPK bound to activator Components(5'-AMP-activated protein kinase subunit ...) x 2 5'-AMP-activated protein kinase catalytic subunit alpha-1 DetailsKeywords TRANSFERASE/ACTIVATOR / Kinase / AMPK / activator / allostery / TRANSFERASE-ACTIVATOR complexFunction / homology Function and homology informationFunction Domain/homology Component
[acetyl-CoA carboxylase] kinase / response to camptothecin / : / : / Energy dependent regulation of mTOR by LKB1-AMPK / eukaryotic elongation factor-2 kinase activator activity / Macroautophagy / cellular response to xenobiotic stimulus => GO:0071466 / Energy dependent regulation of mTOR by LKB1-AMPK / positive regulation of mitochondrial transcription ... [acetyl-CoA carboxylase] kinase / response to camptothecin / : / : / Energy dependent regulation of mTOR by LKB1-AMPK / eukaryotic elongation factor-2 kinase activator activity / Macroautophagy / cellular response to xenobiotic stimulus => GO:0071466 / Energy dependent regulation of mTOR by LKB1-AMPK / positive regulation of mitochondrial transcription / Regulation of TP53 Activity through Phosphorylation / Macroautophagy / TP53 Regulates Metabolic Genes / nail development / [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase / [hydroxymethylglutaryl-CoA reductase (NADPH)] kinase activity / : / regulation of stress granule assembly / histone H2BS36 kinase activity / TP53 Regulates Metabolic Genes / regulation of peptidyl-serine phosphorylation / cold acclimation / positive regulation of peptidyl-lysine acetylation / lipid droplet disassembly / regulation of bile acid secretion / : / import into nucleus / positive regulation of fatty acid oxidation / positive regulation of skeletal muscle tissue development / CAMKK-AMPK signaling cascade / regulation of vesicle-mediated transport / Regulation of TP53 Activity through Phosphorylation / cellular response to organonitrogen compound / protein kinase regulator activity / negative regulation of TOR signaling / negative regulation of hepatocyte apoptotic process / tau-protein kinase / bile acid and bile salt transport / nucleotide-activated protein kinase complex / cellular response to ethanol / protein localization to lipid droplet / bile acid signaling pathway / response to caffeine / motor behavior / positive regulation of protein targeting to mitochondrion / lipid biosynthetic process / negative regulation of tubulin deacetylation / AMP-activated protein kinase activity / positive regulation of protein localization / tau-protein kinase activity / cholesterol biosynthetic process / AMP binding / fatty acid oxidation / cellular response to nutrient levels / fatty acid homeostasis / cellular response to glucose starvation / negative regulation of lipid catabolic process / regulation of microtubule cytoskeleton organization / positive regulation of autophagy / energy homeostasis / response to UV / positive regulation of gluconeogenesis / negative regulation of insulin receptor signaling pathway / negative regulation of TORC1 signaling / positive regulation of adipose tissue development / cellular response to calcium ion / positive regulation of glycolytic process / response to activity / ADP binding / cellular response to glucose stimulus / response to gamma radiation / positive regulation of glucose import / response to hydrogen peroxide / regulation of circadian rhythm / cellular response to hydrogen peroxide / Wnt signaling pathway / autophagy / kinase binding / neuron cellular homeostasis / cellular response to prostaglandin E stimulus / response to estrogen / fatty acid biosynthetic process / glucose metabolic process / rhythmic process / cellular response to xenobiotic stimulus / glucose homeostasis / cellular response to oxidative stress / positive regulation of cold-induced thermogenesis / cellular response to hypoxia / negative regulation of translation / non-specific serine/threonine protein kinase / protein kinase activity / intracellular signal transduction / nuclear speck / response to xenobiotic stimulus / apical plasma membrane / axon / negative regulation of gene expression / protein phosphorylation / protein serine kinase activity Similarity search - Function PRKAA1, UBA-like autoinhibitory domain / 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal / : / AMP-activated protein kinase, alpha subunit, autoinhibitory domain / Association with the SNF1 complex (ASC) domain / ASC domain superfamily / 5'-AMP-activated protein kinase beta subunit, interaction domain / 5'-AMP-activated protein kinase beta subunit, interation domain / AMPK, C-terminal adenylate sensor domain / Adenylate sensor of SNF1-like protein kinase ... PRKAA1, UBA-like autoinhibitory domain / 5'-AMP-activated protein kinase alpha 1 catalytic subunit, C-terminal / : / AMP-activated protein kinase, alpha subunit, autoinhibitory domain / Association with the SNF1 complex (ASC) domain / ASC domain superfamily / 5'-AMP-activated protein kinase beta subunit, interaction domain / 5'-AMP-activated protein kinase beta subunit, interation domain / AMPK, C-terminal adenylate sensor domain / Adenylate sensor of SNF1-like protein kinase / AMP-activated protein kinase, glycogen-binding domain / Glycogen recognition site of AMP-activated protein kinase / KA1 domain/Ssp2, C-terminal / CBS domain superfamily / Domain in cystathionine beta-synthase and other proteins. / CBS domain / CBS domain / CBS domain profile. / Immunoglobulin E-set / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Immunoglobulins / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta Similarity search - Domain/homology Chem-85V / ADENOSINE-5'-DIPHOSPHATE / ADENOSINE MONOPHOSPHATE / STAUROSPORINE / 5'-AMP-activated protein kinase catalytic subunit alpha-1 / 5'-AMP-activated protein kinase subunit gamma-1 / 5'-AMP-activated protein kinase subunit beta-1 / 5'-AMP-activated protein kinase catalytic subunit alpha-1 Similarity search - ComponentBiological species Rattus norvegicus (Norway rat)Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 3.45 Å DetailsAuthors Calabrese, M.F. / Kurumbail, R.G. CitationJournal : Cell Metab. / Year : 2017Title : Activation of Skeletal Muscle AMPK Promotes Glucose Disposal and Glucose Lowering in Non-human Primates and Mice.Authors: Cokorinos, E.C. / Delmore, J. / Reyes, A.R. / Albuquerque, B. / Kjbsted, R. / Jrgensen, N.O. / Tran, J.L. / Jatkar, A. / Cialdea, K. / Esquejo, R.M. / Meissen, J. / Calabrese, M.F. / Cordes, ... Authors : Cokorinos, E.C. / Delmore, J. / Reyes, A.R. / Albuquerque, B. / Kjbsted, R. / Jrgensen, N.O. / Tran, J.L. / Jatkar, A. / Cialdea, K. / Esquejo, R.M. / Meissen, J. / Calabrese, M.F. / Cordes, J. / Moccia, R. / Tess, D. / Salatto, C.T. / Coskran, T.M. / Opsahl, A.C. / Flynn, D. / Blatnik, M. / Li, W. / Kindt, E. / Foretz, M. / Viollet, B. / Ward, J. / Kurumbail, R.G. / Kalgutkar, A.S. / Wojtaszewski, J.F.P. / Cameron, K.O. / Miller, R.A. History Deposition Jan 5, 2017 Deposition site : RCSB / Processing site : RCSBRevision 1.0 May 17, 2017 Provider : repository / Type : Initial release