Entry Database : PDB / ID : 3bxk Structure visualization Downloads & linksTitle Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complex ComponentsCalmodulin Voltage-dependent P/Q-type calcium channel subunit alpha-1A peptide DetailsKeywords MEMBRANE PROTEIN / SIGNALING PROTEIN / ION CHANNEL / CALMODULIN / CALCIUM CHANNEL / IQ DOMAIN / FACILLITATION / INACTIVATION / CALCIUM-DEPENDENT / VOLTAGE-GATED / ROBETTA / SIMULATIONS / Acetylation / Methylation / Phosphoprotein / Calcium transport / Glycoprotein / Ion transport / Ionic channel / Membrane / Transmembrane / Transport / Voltage-gated channelFunction / homology Function and homology informationFunction Domain/homology Component
regulation of store-operated calcium channel activity / regulation of high voltage-gated calcium channel activity / Presynaptic depolarization and calcium channel opening / : / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / : / establishment of protein localization to mitochondrial membrane / type 3 metabotropic glutamate receptor binding ... regulation of store-operated calcium channel activity / regulation of high voltage-gated calcium channel activity / Presynaptic depolarization and calcium channel opening / : / regulation of response to tumor cell / positive regulation of autophagic cell death / DAPK1-calmodulin complex / : / establishment of protein localization to mitochondrial membrane / type 3 metabotropic glutamate receptor binding / high voltage-gated calcium channel activity / establishment of protein localization to membrane / syntaxin binding / regulation of synaptic vesicle endocytosis / negative regulation of high voltage-gated calcium channel activity / regulation of synaptic vesicle exocytosis / negative regulation of calcium ion export across plasma membrane / organelle localization by membrane tethering / regulation of cardiac muscle cell action potential / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / positive regulation of ryanodine-sensitive calcium-release channel activity / voltage-gated calcium channel complex / nitric-oxide synthase binding / protein phosphatase activator activity / calcium ion import across plasma membrane / calcium channel regulator activity / positive regulation of cyclic-nucleotide phosphodiesterase activity / response to amyloid-beta / positive regulation of phosphoprotein phosphatase activity / adenylate cyclase binding / catalytic complex / detection of calcium ion / negative regulation of ryanodine-sensitive calcium-release channel activity / voltage-gated calcium channel activity / regulation of cardiac muscle contraction / calcium channel inhibitor activity / cellular response to interferon-beta / positive regulation of DNA binding / enzyme regulator activity / voltage-gated potassium channel complex / phosphatidylinositol 3-kinase binding / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / regulation of calcium-mediated signaling / positive regulation of protein dephosphorylation / titin binding / regulation of ryanodine-sensitive calcium-release channel activity / potassium ion transmembrane transport / sperm midpiece / response to amphetamine / calcium channel complex / activation of adenylate cyclase activity / adenylate cyclase activator activity / regulation of heart rate / nitric-oxide synthase regulator activity / protein serine/threonine kinase activator activity / sarcomere / regulation of cytokinesis / cell projection / Regulation of insulin secretion / positive regulation of nitric-oxide synthase activity / calcium-mediated signaling / spindle microtubule / calcium ion transmembrane transport / positive regulation of receptor signaling pathway via JAK-STAT / modulation of chemical synaptic transmission / spindle pole / cellular response to type II interferon / response to calcium ion / calcium-dependent protein binding / cellular response to amyloid-beta / disordered domain specific binding / G2/M transition of mitotic cell cycle / myelin sheath / amyloid-beta binding / positive regulation of cytosolic calcium ion concentration / growth cone / chemical synaptic transmission / vesicle / transmembrane transporter binding / protein autophosphorylation / neuron projection / positive regulation of apoptotic process / protein domain specific binding / centrosome / neuronal cell body / synapse / calcium ion binding / protein kinase binding / protein-containing complex / mitochondrion / nucleoplasm / membrane / metal ion binding / nucleus / plasma membrane / cytosol / cytoplasm Similarity search - Function Voltage-dependent calcium channel, P/Q-type, alpha-1 A / Voltage-dependent calcium channel, alpha-1 subunit, IQ domain / Voltage gated calcium channel IQ domain / Voltage gated calcium channel IQ domain / Voltage-dependent calcium channel, alpha-1 subunit / Voltage-dependent L-type calcium channel, IQ-associated domain / Voltage-dependent L-type calcium channel, IQ-associated / Voltage-dependent channel domain superfamily / EF-hand / Recoverin; domain 1 ... Voltage-dependent calcium channel, P/Q-type, alpha-1 A / Voltage-dependent calcium channel, alpha-1 subunit, IQ domain / Voltage gated calcium channel IQ domain / Voltage gated calcium channel IQ domain / Voltage-dependent calcium channel, alpha-1 subunit / Voltage-dependent L-type calcium channel, IQ-associated domain / Voltage-dependent L-type calcium channel, IQ-associated / Voltage-dependent channel domain superfamily / EF-hand / Recoverin; domain 1 / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / Ion transport domain / Ion transport protein / EF-hand domain / EF-hand domain pair / Orthogonal Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Rattus norvegicus (Norway rat)Method X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution : 2.55 Å DetailsAuthors Mori, M.X. / Vander Kooi, C.W. / Leahy, D.J. / Yue, D.T. CitationJournal : To be Published Title : Crystal structure of the P/Q-type calcium channel (CaV2.1) IQ domain and CA2+calmodulin complexAuthors : Mori, M.X. / Vander Kooi, C.W. / Leahy, D.J. / Yue, D.T. History Deposition Jan 14, 2008 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 25, 2008 Provider : repository / Type : Initial releaseRevision 1.1 Jul 13, 2011 Group : Advisory / Version format complianceRevision 1.2 Feb 21, 2024 Group : Data collection / Database references / Derived calculationsCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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