Entry Database : PDB / ID : 2v40 Structure visualization Downloads & linksTitle Human Adenylosuccinate synthetase isozyme 2 in complex with GDP ComponentsADENYLOSUCCINATE SYNTHETASE ISOZYME 2 Details Keywords LIGASE / PURINE BIOSYNTHESIS / ADENYLOSUCCINATE SYNTHETASE / METAL- BINDING / PURINE METABOLISM / NUCLEOTIDE-BINDING / GDP / ADSS2 / MAGNESIUM / GTP-BINDINGFunction / homology Function and homology informationFunction Domain/homology Component
AMP biosynthetic process / adenylosuccinate synthase / adenylosuccinate synthase activity / purine ribonucleoside monophosphate biosynthetic process / aspartate metabolic process / response to ammonium ion / cellular response to electrical stimulus / IMP metabolic process / Purine ribonucleoside monophosphate biosynthesis / 'de novo' AMP biosynthetic process ... AMP biosynthetic process / adenylosuccinate synthase / adenylosuccinate synthase activity / purine ribonucleoside monophosphate biosynthetic process / aspartate metabolic process / response to ammonium ion / cellular response to electrical stimulus / IMP metabolic process / Purine ribonucleoside monophosphate biosynthesis / 'de novo' AMP biosynthetic process / response to purine-containing compound / immune system process / phosphate ion binding / GTP binding / magnesium ion binding / mitochondrion / extracellular exosome / plasma membrane / cytosol / cytoplasm Similarity search - Function Adenylosuccinate synthetase isozyme 2, chordates / Adenylosuccinate Synthetase, subunit A; domain 2 / Adenylosuccinate Synthetase, subunit A, domain 2 / Adenylosuccinate Synthetase; Chain A, domain 1 / Adenylosuccinate Synthetase, subunit A, domain 1 / Adenylosuccinate Synthetase; Chain A, domain 3 / Adenylosuccinate Synthetase, subunit A, domain 3 / Adenylosuccinate synthase, active site / Adenylosuccinate synthetase active site. / Adenylosuccinate synthase, GTP-binding site ... Adenylosuccinate synthetase isozyme 2, chordates / Adenylosuccinate Synthetase, subunit A; domain 2 / Adenylosuccinate Synthetase, subunit A, domain 2 / Adenylosuccinate Synthetase; Chain A, domain 1 / Adenylosuccinate Synthetase, subunit A, domain 1 / Adenylosuccinate Synthetase; Chain A, domain 3 / Adenylosuccinate Synthetase, subunit A, domain 3 / Adenylosuccinate synthase, active site / Adenylosuccinate synthetase active site. / Adenylosuccinate synthase, GTP-binding site / Adenylosuccinate synthetase, domain 2 / Adenylosuccinate synthetase, domain 3 / Adenylosuccinate synthetase GTP-binding site. / Adenylosuccinate synthetase / Adenylosuccinate synthetase, domain 1 / Adenylosuccinate synthetase / Adenylosuccinate synthetase / Alpha-Beta Complex / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homologyBiological species HOMO SAPIENS (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.9 Å DetailsAuthors Welin, M. / Moche, M. / Arrowsmith, C. / Berglund, H. / Busam, R. / Collins, R. / Dahlgren, L.G. / Edwards, A. / Flodin, S. / Flores, A. ...Welin, M. / Moche, M. / Arrowsmith, C. / Berglund, H. / Busam, R. / Collins, R. / Dahlgren, L.G. / Edwards, A. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. / Hallberg, B.M. / Holmberg-Schiavone, L. / Johansson, I. / Kallas, A. / Karlberg, T. / Kotenyova, T. / Lehtio, L. / Nyman, T. / Ogg, D. / Persson, C. / Sagemark, J. / Stenmark, P. / Sundstrom, M. / Thorsell, A.G. / Tresaugues, L. / van den Berg, S. / Weigelt, J. / Nordlund, P. / Structural Genomics Consortium (SGC) CitationJournal : To be Published Title : Human Adenylosuccinate Synthetase Isozyme 2 in Complex with GdpAuthors: Welin, M. / Moche, M. / Arrowsmith, C. / Berglund, H. / Busam, R. / Collins, R. / Dahlgren, L.G. / Edwards, A. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. / Hallberg, B.M. / ... Authors : Welin, M. / Moche, M. / Arrowsmith, C. / Berglund, H. / Busam, R. / Collins, R. / Dahlgren, L.G. / Edwards, A. / Flodin, S. / Flores, A. / Graslund, S. / Hammarstrom, M. / Hallberg, B.M. / Holmberg-Schiavone, L. / Johansson, I. / Kallas, A. / Karlberg, T. / Kotenyova, T. / Lehtio, L. / Nyman, T. / Ogg, D. / Persson, C. / Sagemark, J. / Stenmark, P. / Sundstrom, M. / Thorsell, A.G. / van den Berg, S. / Weigelt, J. / Nordlund, P. History Deposition Jun 27, 2007 Deposition site : PDBE / Processing site : PDBERevision 1.0 Jul 10, 2007 Provider : repository / Type : Initial releaseRevision 1.1 Dec 13, 2017 Group : Database references / Category : citation_author / Item : _citation_author.nameRevision 1.2 Dec 13, 2023 Group : Data collection / Database references ... Data collection / Database references / Other / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_database_status / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_database_status.status_code_sf
Show all Show less Remark 650 HELIX DETERMINATION METHOD: AUTHOR PROVIDED. Remark 700 SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN ... SHEET THE SHEET STRUCTURE OF THIS MOLECULE IS BIFURCATED. IN ORDER TO REPRESENT THIS FEATURE IN THE SHEET RECORDS BELOW, TWO SHEETS ARE DEFINED.