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- PDB-2ckn: NMR Structure of the First Ig Module of mouse FGFR1 -

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Basic information

Entry
Database: PDB / ID: 2ckn
TitleNMR Structure of the First Ig Module of mouse FGFR1
ComponentsBASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1
KeywordsTRANSFERASE / KINASE / HEPARIN-BINDING / NUCLEOTIDE-BINDING / IMMUNOGLOBULIN DOMAIN / ALTERNATICE SPLICING / ATP-BINDING / GLYCOPROTEIN / RECEPTOR / TYROSINE-PROTEIN KINASE
Function / homology
Function and homology information


motogenic signaling involved in postnatal olfactory bulb interneuron migration / FGFR1c and Klotho ligand binding and activation / Phospholipase C-mediated cascade: FGFR1 / regulation of phosphorus metabolic process / FGFR1b ligand binding and activation / FGFR1c ligand binding and activation / Downstream signaling of activated FGFR1 / SHC-mediated cascade:FGFR1 / Signal transduction by L1 / PI-3K cascade:FGFR1 ...motogenic signaling involved in postnatal olfactory bulb interneuron migration / FGFR1c and Klotho ligand binding and activation / Phospholipase C-mediated cascade: FGFR1 / regulation of phosphorus metabolic process / FGFR1b ligand binding and activation / FGFR1c ligand binding and activation / Downstream signaling of activated FGFR1 / SHC-mediated cascade:FGFR1 / Signal transduction by L1 / PI-3K cascade:FGFR1 / FRS-mediated FGFR1 signaling / PI3K Cascade / Negative regulation of FGFR1 signaling / vasculogenesis involved in coronary vascular morphogenesis / orbitofrontal cortex development / negative regulation of fibroblast growth factor production / positive regulation of mitotic cell cycle DNA replication / regulation of extrinsic apoptotic signaling pathway in absence of ligand / RAF/MAP kinase cascade / vitamin D3 metabolic process / positive regulation of hepatic stellate cell activation / regulation of phosphate transport / regulation of lateral mesodermal cell fate specification / positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway / positive regulation of endothelial cell chemotaxis to fibroblast growth factor / receptor-receptor interaction / PIP3 activates AKT signaling / regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling / fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development / regulation of sensory perception of pain / auditory receptor cell development / ventricular zone neuroblast division / multicellular organism development / mesenchymal cell differentiation / positive regulation of parathyroid hormone secretion / ear development / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / paraxial mesoderm development / regulation of stem cell proliferation / fibroblast growth factor receptor activity / branching involved in salivary gland morphogenesis / organ induction / lung-associated mesenchyme development / positive regulation of kinase activity / positive regulation of fibroblast migration / outer ear morphogenesis / middle ear morphogenesis / embryonic limb morphogenesis / blood vessel morphogenesis / ureteric bud development / positive regulation of vascular endothelial cell proliferation / positive regulation of mesenchymal cell proliferation / inner ear morphogenesis / generation of neurons / midbrain development / stem cell population maintenance / central nervous system neuron development / fibroblast growth factor binding / plasma membrane => GO:0005886 / epithelial to mesenchymal transition / negative regulation of osteoblast differentiation / positive regulation of blood vessel endothelial cell migration / fibroblast growth factor receptor signaling pathway / chondrocyte differentiation / positive regulation of phospholipase C activity / salivary gland morphogenesis / positive regulation of cell cycle / cell maturation / positive regulation of cardiac muscle cell proliferation / positive regulation of neuron differentiation / cell adhesion molecule binding / SH2 domain binding / transmembrane receptor protein tyrosine kinase activity / positive regulation of cell differentiation / sensory perception of sound / lung development / brain development / positive regulation of MAP kinase activity / positive regulation of neuron projection development / receptor protein-tyrosine kinase / positive regulation of inflammatory response / peptidyl-tyrosine phosphorylation / neuron projection development / cell surface receptor protein tyrosine kinase signaling pathway / heparin binding / regulation of cell population proliferation / cytoplasmic vesicle / regulation of gene expression / angiogenesis / protein tyrosine kinase activity / in utero embryonic development / positive regulation of MAPK cascade / protein autophosphorylation / positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction / receptor complex / negative regulation of gene expression / signaling receptor binding / positive regulation of cell population proliferation / protein-containing complex binding / perinuclear region of cytoplasm
Similarity search - Function
: / : / Fibroblast growth factor receptor 1, catalytic domain / Fibroblast growth factor receptor family / Immunoglobulin / Immunoglobulin domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type ...: / : / Fibroblast growth factor receptor 1, catalytic domain / Fibroblast growth factor receptor family / Immunoglobulin / Immunoglobulin domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta
Similarity search - Domain/homology
Fibroblast growth factor receptor 1
Similarity search - Component
Biological speciesMUS MUSCULUS (house mouse)
MethodSOLUTION NMR
AuthorsKiselyov, V.V. / Bock, E. / Berezin, V. / Poulsen, F.M.
CitationJournal: Protein Sci. / Year: 2006
Title: NMR Structure of the First Ig Module of Mouse Fgfr1.
Authors: Kiselyov, V.V. / Bock, E. / Berezin, V. / Poulsen, F.M.
History
DepositionApr 20, 2006Deposition site: PDBE / Processing site: PDBE
Revision 1.0May 31, 2006Provider: repository / Type: Initial release
Revision 1.1Apr 19, 2017Group: Other
Revision 1.2Jan 15, 2020Group: Other / Category: pdbx_database_status / Item: _pdbx_database_status.status_code_cs

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

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Assembly

Deposited unit
A: BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1


Theoretical massNumber of molelcules
Total (without water)10,4621
Polymers10,4621
Non-polymers00
Water0
1


  • Idetical with deposited unit
  • defined by author
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
NMR ensembles
DataCriteria
Number of conformers (submitted / calculated)20 / -
Representative

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Components

#1: Protein BASIC FIBROBLAST GROWTH FACTOR RECEPTOR 1 / FGFR-1 / BFGF-R / MFR


Mass: 10461.557 Da / Num. of mol.: 1 / Fragment: IG1 MODULE OF MOUSE FGFR1, RESIDUES 25-119 / Source method: obtained synthetically / Source: (synth.) MUS MUSCULUS (house mouse)
References: UniProt: P16092, receptor protein-tyrosine kinase

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Experimental details

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Experiment

ExperimentMethod: SOLUTION NMR
NMR detailsText: NONE

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Sample preparation

Sample conditionsTemperature: 298.0 K

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NMR measurement

NMR spectrometer
TypeManufacturerModelField strength (MHz)Spectrometer-ID
Varian INOVAVarianINOVA7501
Varian INOVAVarianINOVA8002

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Processing

NMR softwareName: X-PLOR / Developer: BRUNGER / Classification: refinement
NMR ensembleConformers submitted total number: 20

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