Entry Database : PDB / ID : 1r8u Structure visualization Downloads & linksTitle NMR structure of CBP TAZ1/CITED2 complex ComponentsCREB-binding protein Cbp/p300-interacting transactivator 2 DetailsKeywords TRANSCRIPTION/TRANSCRIPTION ACTIVATOR / zinc-binding motifs / protein-protein complex / TAZ zinc finger / TRANSCRIPTION-TRANSCRIPTION ACTIVATOR COMPLEXFunction / homology Function and homology informationFunction Domain/homology Component
cranial nerve morphogenesis / TFAP2 (AP-2) family regulates transcription of other transcription factors / embryonic process involved in female pregnancy / left/right pattern formation / pulmonary artery morphogenesis / embryonic heart tube left/right pattern formation / Activation of the TFAP2 (AP-2) family of transcription factors / Regulation of FOXO transcriptional activity by acetylation / regulation of animal organ formation / adrenal cortex formation ... cranial nerve morphogenesis / TFAP2 (AP-2) family regulates transcription of other transcription factors / embryonic process involved in female pregnancy / left/right pattern formation / pulmonary artery morphogenesis / embryonic heart tube left/right pattern formation / Activation of the TFAP2 (AP-2) family of transcription factors / Regulation of FOXO transcriptional activity by acetylation / regulation of animal organ formation / adrenal cortex formation / TRAF6 mediated IRF7 activation / Nuclear events mediated by NFE2L2 / nodal signaling pathway / Attenuation phase / embryonic camera-type eye morphogenesis / Regulation of gene expression by Hypoxia-inducible Factor / LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production / RUNX1 regulates transcription of genes involved in differentiation of myeloid cells / cAMP response element binding protein binding / Formation of the beta-catenin:TCF transactivating complex / NOTCH1 Intracellular Domain Regulates Transcription / RUNX3 regulates NOTCH signaling / sex determination / Notch-HLH transcription pathway / positive regulation of male gonad development / endocardial cushion development / determination of left/right asymmetry in lateral mesoderm / positive regulation of peroxisome proliferator activated receptor signaling pathway / granulocyte differentiation / lens morphogenesis in camera-type eye / positive regulation of cell adhesion molecule production / germ-line stem cell population maintenance / left/right axis specification / positive regulation of cell-cell adhesion / negative regulation of cardiac muscle cell proliferation / Regulation of lipid metabolism by PPARalpha / negative regulation of viral process / Cytoprotection by HMOX1 / response to fluid shear stress / trophectodermal cell differentiation / CD209 (DC-SIGN) signaling / Estrogen-dependent gene expression / outer kinetochore / peripheral nervous system development / negative regulation of interferon-beta production / cardiac neural crest cell development involved in heart development / Activation of the TFAP2 (AP-2) family of transcription factors / histone H3K27 acetyltransferase activity / histone H3K18 acetyltransferase activity / N-terminal peptidyl-lysine acetylation / MRF binding / bone morphogenesis / peroxisome proliferator activated receptor binding / determination of left/right symmetry / face morphogenesis / negative regulation of transcription by RNA polymerase I / positive regulation of dendritic spine development / Regulation of gene expression by Hypoxia-inducible Factor / histone acetyltransferase binding / peptide-lysine-N-acetyltransferase activity / erythrocyte development / FOXO-mediated transcription of cell death genes / cellular response to hepatocyte growth factor stimulus / ventricular septum morphogenesis / heart looping / LBD domain binding / outflow tract morphogenesis / positive regulation of transforming growth factor beta receptor signaling pathway / SMAD binding / skeletal muscle cell differentiation / non-canonical NF-kappaB signal transduction / behavioral response to cocaine / acetyltransferase activity / uterus development / cellular response to nutrient levels / TFIIB-class transcription factor binding / decidualization / histone acetyltransferase complex / positive regulation of G1/S transition of mitotic cell cycle / long-term memory / embryonic placenta development / vasculogenesis / hematopoietic progenitor cell differentiation / positive regulation of cell cycle / response to mechanical stimulus / histone acetyltransferase activity / histone acetyltransferase / Transferases; Acyltransferases; Transferring groups other than aminoacyl groups / spleen development / transforming growth factor beta receptor signaling pathway / negative regulation of cell migration / thymus development / liver development / central nervous system development / molecular function activator activity / neural tube closure / RNA polymerase II transcription regulatory region sequence-specific DNA binding / protein destabilization / protein modification process / transcription coactivator binding Similarity search - Function Helix Hairpins - #2200 / CITED / CITED / CREB-binding Protein; Chain A / TAZ domain / Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily ... Helix Hairpins - #2200 / CITED / CITED / CREB-binding Protein; Chain A / TAZ domain / Nuclear receptor coactivator, CREB-bp-like, interlocking / Nuclear receptor coactivator, CREB-bp-like, interlocking domain superfamily / Creb binding / Zinc finger, TAZ-type / TAZ domain superfamily / TAZ zinc finger / Zinc finger TAZ-type profile. / TAZ zinc finger, present in p300 and CBP / Coactivator CBP, KIX domain / CREB-binding protein/p300, atypical RING domain / CBP/p300-type histone acetyltransferase domain / CBP/p300, atypical RING domain superfamily / KIX domain / CREB-binding protein/p300, atypical RING domain / KIX domain profile. / CBP/p300-type histone acetyltransferase (HAT) domain profile. / Histone acetyltransferase Rtt109/CBP / Histone acetylation protein / Histone acetylation protein / Coactivator CBP, KIX domain superfamily / Zinc finger ZZ-type signature. / Zinc-binding domain, present in Dystrophin, CREB-binding protein. / Zinc finger, ZZ type / Zinc finger, ZZ-type / Zinc finger, ZZ-type superfamily / Zinc finger ZZ-type profile. / Helix Hairpins / Nuclear receptor coactivator, interlocking / Helix non-globular / Special / Bromodomain, conserved site / Bromodomain signature. / Bromodomain / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Zinc finger, RING/FYVE/PHD-type / Up-down Bundle / Mainly Alpha Similarity search - Domain/homologyBiological species Homo sapiens (human)Mus musculus (house mouse)Method SOLUTION NMR / AMBER simulated annealing , minimization DetailsAuthors De Guzman, R.N. / Martinez-Yamout, M. / Dyson, H.J. / Wright, P.E. CitationJournal : J.Biol.Chem. / Year : 2004Title : Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites.Authors : De Guzman, R.N. / Martinez-Yamout, M.A. / Dyson, H.J. / Wright, P.E. History Deposition Oct 28, 2003 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 23, 2004 Provider : repository / Type : Initial releaseRevision 1.1 Apr 29, 2008 Group : Version format complianceRevision 1.2 Jul 13, 2011 Group : Version format complianceRevision 1.3 Mar 2, 2022 Group : Data collection / Database references / Derived calculationsCategory : database_2 / pdbx_nmr_software ... database_2 / pdbx_nmr_software / pdbx_nmr_spectrometer / pdbx_struct_assembly / pdbx_struct_conn_angle / pdbx_struct_oper_list / struct_conn / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_nmr_software.name / _pdbx_nmr_spectrometer.model / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
Show all Show less