+Open data
-Basic information
Entry | Database: PDB / ID: 1pls | ||||||
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Title | SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN | ||||||
Components | PLECKSTRIN HOMOLOGY DOMAIN | ||||||
Keywords | PHOSPHORYLATION | ||||||
Function / homology | Function and homology information positive regulation of inositol-polyphosphate 5-phosphatase activity / protein secretion by platelet / phospholipase C-inhibiting G protein-coupled receptor signaling pathway / regulation of cell diameter / thrombin-activated receptor signaling pathway / negative regulation of inositol phosphate biosynthetic process / negative regulation of calcium-mediated signaling / positive regulation of actin filament depolymerization / protein kinase C signaling / platelet degranulation ...positive regulation of inositol-polyphosphate 5-phosphatase activity / protein secretion by platelet / phospholipase C-inhibiting G protein-coupled receptor signaling pathway / regulation of cell diameter / thrombin-activated receptor signaling pathway / negative regulation of inositol phosphate biosynthetic process / negative regulation of calcium-mediated signaling / positive regulation of actin filament depolymerization / protein kinase C signaling / platelet degranulation / negative regulation of G protein-coupled receptor signaling pathway / phosphatidylinositol metabolic process / positive regulation of actin filament bundle assembly / positive regulation of integrin activation / vesicle docking involved in exocytosis / cell projection organization / ruffle organization / positive regulation of platelet activation / phosphatidylinositol-3,4-bisphosphate binding / cortical actin cytoskeleton organization / hematopoietic progenitor cell differentiation / protein kinase C binding / integrin-mediated signaling pathway / platelet aggregation / ruffle membrane / Platelet degranulation / actin cytoskeleton organization / protein homodimerization activity / extracellular region / membrane / plasma membrane / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Yoon, H.S. / Hajduk, P.J. / Petros, A.M. / Olejniczak, E.T. / Meadows, R.P. / Fesik, S.W. | ||||||
Citation | Journal: Nature / Year: 1994 Title: Solution structure of a pleckstrin-homology domain. Authors: Yoon, H.S. / Hajduk, P.J. / Petros, A.M. / Olejniczak, E.T. / Meadows, R.P. / Fesik, S.W. #1: Journal: Nature / Year: 1994 Title: Pleckstrin Homology Domains Bind to Phosphatidylinositol-4,5-Biphosphate Authors: Harlan, J.E. / Hajduk, P.J. / Yoon, H.S. / Fesik, S.W. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1pls.cif.gz | 901.1 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1pls.ent.gz | 781.9 KB | Display | PDB format |
PDBx/mmJSON format | 1pls.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/pl/1pls ftp://data.pdbj.org/pub/pdb/validation_reports/pl/1pls | HTTPS FTP |
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-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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Atom site foot note | 1: CIS PROLINE - PRO 58 | |||||||||
NMR ensembles |
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-Components
#1: Protein | Mass: 13341.479 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Gene: CDNA / References: UniProt: P08567 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Crystal grow | *PLUS Method: other |
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-Processing
Software |
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NMR software | Name: X-PLOR / Developer: BRUNGER / Classification: refinement | ||||||||
NMR ensemble | Conformers submitted total number: 25 |