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Yorodumi- PDB-1lxl: NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, M... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1lxl | ||||||
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Title | NMR STRUCTURE OF BCL-XL, AN INHIBITOR OF PROGRAMMED CELL DEATH, MINIMIZED AVERAGE STRUCTURE | ||||||
Components | BCL-XL | ||||||
Keywords | APOPTOSIS / PROGRAMMED CELL DEATH / BCL-2 FAMILY | ||||||
Function / homology | Function and homology information apoptotic process in bone marrow cell / The NLRP1 inflammasome / SARS-CoV-1-mediated effects on programmed cell death / dendritic cell apoptotic process / dendritic cell proliferation / positive regulation of mononuclear cell proliferation / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / negative regulation of dendritic cell apoptotic process / negative regulation of execution phase of apoptosis ...apoptotic process in bone marrow cell / The NLRP1 inflammasome / SARS-CoV-1-mediated effects on programmed cell death / dendritic cell apoptotic process / dendritic cell proliferation / positive regulation of mononuclear cell proliferation / BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members / negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage / negative regulation of dendritic cell apoptotic process / negative regulation of execution phase of apoptosis / negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway / fertilization / negative regulation of protein localization to plasma membrane / regulation of mitochondrial membrane permeability / regulation of growth / Bcl-2 family protein complex / NFE2L2 regulating tumorigenic genes / response to cycloheximide / cellular response to alkaloid / STAT5 activation downstream of FLT3 ITD mutants / hepatocyte apoptotic process / negative regulation of reproductive process / negative regulation of developmental process / negative regulation of release of cytochrome c from mitochondria / BH3 domain binding / apoptotic mitochondrial changes / germ cell development / negative regulation of anoikis / negative regulation of extrinsic apoptotic signaling pathway in absence of ligand / ectopic germ cell programmed cell death / negative regulation of intrinsic apoptotic signaling pathway / negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway / negative regulation of extrinsic apoptotic signaling pathway via death domain receptors / ovarian follicle development / extrinsic apoptotic signaling pathway in absence of ligand / negative regulation of autophagy / release of cytochrome c from mitochondria / regulation of mitochondrial membrane potential / regulation of cytokinesis / epithelial cell proliferation / response to cytokine / cellular response to amino acid stimulus / cellular response to gamma radiation / synaptic vesicle membrane / endocytosis / RAS processing / male gonad development / intrinsic apoptotic signaling pathway in response to DNA damage / spermatogenesis / defense response to virus / neuron apoptotic process / Interleukin-4 and Interleukin-13 signaling / nuclear membrane / in utero embryonic development / mitochondrial inner membrane / negative regulation of neuron apoptotic process / mitochondrial outer membrane / mitochondrial matrix / protein heterodimerization activity / centrosome / negative regulation of apoptotic process / protein kinase binding / endoplasmic reticulum / protein homodimerization activity / mitochondrion / identical protein binding / cytosol / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | SOLUTION NMR | ||||||
Authors | Muchmore, S.W. / Sattler, M. / Liang, H. / Meadows, R.P. / Harlan, J.E. / Yoon, H.S. / Nettesheim, D. / Chang, B.S. / Thompson, C.B. / Wong, S.L. ...Muchmore, S.W. / Sattler, M. / Liang, H. / Meadows, R.P. / Harlan, J.E. / Yoon, H.S. / Nettesheim, D. / Chang, B.S. / Thompson, C.B. / Wong, S.L. / Ng, S.C. / Fesik, S.W. | ||||||
Citation | Journal: Nature / Year: 1996 Title: X-ray and NMR structure of human Bcl-xL, an inhibitor of programmed cell death. Authors: Muchmore, S.W. / Sattler, M. / Liang, H. / Meadows, R.P. / Harlan, J.E. / Yoon, H.S. / Nettesheim, D. / Chang, B.S. / Thompson, C.B. / Wong, S.L. / Ng, S.L. / Fesik, S.W. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1lxl.cif.gz | 81.9 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1lxl.ent.gz | 67.7 KB | Display | PDB format |
PDBx/mmJSON format | 1lxl.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/lx/1lxl ftp://data.pdbj.org/pub/pdb/validation_reports/lx/1lxl | HTTPS FTP |
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-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 24879.371 Da / Num. of mol.: 1 Fragment: RESIDUES 1-209, LACKING THE C-TERMINAL HYDROPHOBIC REGION Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / Plasmid: PET29B / Production host: Escherichia coli (E. coli) / Strain (production host): HMS174 (DE3) / References: UniProt: Q07817 |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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NMR details | Text: NMR SPECTRA WERE RECORDED ON 1-3 MM SOLUTIONS OF BCL-XL IN 20 MM SODIUM PHOSPHATE BUFFER (PH 7.3), 5 MM DTT AND 1MM EDTA AT 303K. |
-Sample preparation
Sample conditions | pH: 7.3 / Temperature: 303 K |
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Crystal grow | *PLUS Method: other / Details: NMR |
-Processing
Software |
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NMR software | Name: X-PLOR / Version: 3.1 / Developer: BRUNGER / Classification: refinement | ||||||||||||
NMR ensemble | Conformers submitted total number: 1 |