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Yorodumi- PDB-1cdr: STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT... -
+Open data
-Basic information
Entry | Database: PDB / ID: 1cdr | |||||||||
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Title | STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59 | |||||||||
Components | CD59 | |||||||||
Keywords | COMPLEMENT REGULATORY PROTEIN | |||||||||
Function / homology | Function and homology information negative regulation of activation of membrane attack complex / complement binding / regulation of complement-dependent cytotoxicity / regulation of complement activation / Cargo concentration in the ER / COPII-mediated vesicle transport / tertiary granule membrane / specific granule membrane / COPI-mediated anterograde transport / transport vesicle ...negative regulation of activation of membrane attack complex / complement binding / regulation of complement-dependent cytotoxicity / regulation of complement activation / Cargo concentration in the ER / COPII-mediated vesicle transport / tertiary granule membrane / specific granule membrane / COPI-mediated anterograde transport / transport vesicle / endoplasmic reticulum-Golgi intermediate compartment membrane / Regulation of Complement cascade / ER to Golgi transport vesicle membrane / blood coagulation / vesicle / cell surface receptor signaling pathway / external side of plasma membrane / Golgi membrane / focal adhesion / Neutrophil degranulation / endoplasmic reticulum membrane / cell surface / extracellular space / extracellular exosome / membrane / plasma membrane Similarity search - Function | |||||||||
Biological species | Homo sapiens (human) | |||||||||
Method | SOLUTION NMR | |||||||||
Authors | Fletcher, C.M. / Harrison, R.A. / Lachmann, P.J. / Neuhaus, D. | |||||||||
Citation | Journal: Structure / Year: 1994 Title: Structure of a soluble, glycosylated form of the human complement regulatory protein CD59. Authors: Fletcher, C.M. / Harrison, R.A. / Lachmann, P.J. / Neuhaus, D. #1: Journal: Protein Sci. / Year: 1993 Title: Sequence-Specific 1H-NMR Assignments and Folding Topology of Human Cd59 Authors: Fletcher, C.M. / Harrison, R.A. / Lachmann, P.J. / Neuhaus, D. #2: Journal: Immunol.Res. / Year: 1993 Title: Membrane Defence Against Complement Lysis: The Structure and Biological Properties of Cd59 Authors: Davies, A. / Lachmann, P.J. | |||||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1cdr.cif.gz | 250.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1cdr.ent.gz | 208.9 KB | Display | PDB format |
PDBx/mmJSON format | 1cdr.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/cd/1cdr ftp://data.pdbj.org/pub/pdb/validation_reports/cd/1cdr | HTTPS FTP |
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-Related structure data
-Links
-Assembly
Deposited unit |
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1 |
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Atom site foot note | 1: ASN 18 IS COVALENTLY BOUND THROUGH ND2 TO NAG 78 AT C1. | |||||||||
NMR ensembles |
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-Components
#1: Protein | Mass: 8970.106 Da / Num. of mol.: 1 Source method: isolated from a genetically manipulated source Source: (gene. exp.) Homo sapiens (human) / References: UniProt: P13987 |
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#2: Polysaccharide | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta- ...2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose Source method: isolated from a genetically manipulated source |
-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR |
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-Sample preparation
Crystal grow | *PLUS Method: other / Details: NMR |
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-Processing
Software |
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NMR software | Name: X-PLOR / Developer: BRUNGER / Classification: refinement | ||||||||
NMR ensemble | Conformers submitted total number: 10 |