登録情報 | データベース: PDB / ID: 7z3j |
---|
タイトル | Structure of crystallisable rat Phospholipase C gamma 1 in complex with inositol 1,4,5-trisphosphate |
---|
要素 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 |
---|
キーワード | HYDROLASE (加水分解酵素) / HYDROLASE COMPLEX AUTOINHIBITED STATE |
---|
機能・相同性 | 機能・相同性情報
PECAM1 interactions / EGFR interacts with phospholipase C-gamma / Activated NTRK2 signals through PLCG1 / Activated NTRK3 signals through PLCG1 / phosphatidylinositol catabolic process / Phospholipase C-mediated cascade: FGFR1 / Phospholipase C-mediated cascade; FGFR3 / Phospholipase C-mediated cascade; FGFR4 / FCERI mediated Ca+2 mobilization / ISG15 antiviral mechanism ...PECAM1 interactions / EGFR interacts with phospholipase C-gamma / Activated NTRK2 signals through PLCG1 / Activated NTRK3 signals through PLCG1 / phosphatidylinositol catabolic process / Phospholipase C-mediated cascade: FGFR1 / Phospholipase C-mediated cascade; FGFR3 / Phospholipase C-mediated cascade; FGFR4 / FCERI mediated Ca+2 mobilization / ISG15 antiviral mechanism / Generation of second messenger molecules / Phospholipase C-mediated cascade; FGFR2 / Downstream signal transduction / Signaling by ALK / Role of phospholipids in phagocytosis / inositol trisphosphate biosynthetic process / DAP12 signaling / VEGFR2 mediated cell proliferation / calcium-dependent phospholipase C activity / Synthesis of IP3 and IP4 in the cytosol / RET signaling / inositol trisphosphate metabolic process / response to curcumin / phosphoinositide phospholipase C / FCERI mediated MAPK activation / response to gravity / phosphatidylinositol metabolic process / phosphatidylinositol phospholipase C activity / COP9 signalosome / phospholipase C activity / neurotrophin TRKA receptor binding / positive regulation of endothelial cell apoptotic process / phosphatidylinositol-mediated signaling / positive regulation of vascular endothelial cell proliferation / クラスリン / positive regulation of epithelial cell migration / glutamate receptor binding / positive regulation of blood vessel endothelial cell migration / release of sequestered calcium ion into cytosol / cellular response to epidermal growth factor stimulus / response to organonitrogen compound / ruffle / guanyl-nucleotide exchange factor activity / positive regulation of release of sequestered calcium ion into cytosol / cell projection / calcium-mediated signaling / phosphoprotein binding / modulation of chemical synaptic transmission / Schaffer collateral - CA1 synapse / response to hydrogen peroxide / insulin receptor binding / epidermal growth factor receptor signaling pathway / receptor tyrosine kinase binding / ruffle membrane / positive regulation of angiogenesis / calcium ion transport / cell-cell junction / 遊走 / lamellipodium / T cell receptor signaling pathway / in utero embryonic development / glutamatergic synapse / calcium ion binding / protein kinase binding / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase X-box domain profile. ...1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma / PLC-gamma, C-terminal SH2 domain / PLC-gamma, N-terminal SH2 domain / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol-specific phospholipase X-box domain profile. / Phosphatidylinositol-specific phospholipase C, X domain / Phosphatidylinositol-specific phospholipase C, X domain / Phospholipase C, catalytic domain (part); domain X / PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily / C2ドメイン / Protein kinase C conserved region 2 (CalB) / C2ドメイン / C2 domain profile. / PH domain / C2 domain superfamily / PH domain profile. / Pleckstrin homology domain. / Pleckstrin homology domain / SH3ドメイン / SH2ドメイン / Src homology 2 (SH2) domain profile. / Src homology 2 domains / Src homology 3 domains / SH2ドメイン / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / SH2 domain superfamily / EF-hand calcium-binding domain profile. / SH3-like domain superfamily / Src homology 3 (SH3) domain profile. / SH3ドメイン / EF-hand domain / EF-hand domain pair / PH-like domain superfamily類似検索 - ドメイン・相同性 D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1類似検索 - 構成要素 |
---|
生物種 | Rattus norvegicus (ドブネズミ) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2 Å |
---|
データ登録者 | Pinotsis, N. / Bunney, T.D. / Katan, M. |
---|
資金援助 | 英国, 1件 組織 | 認可番号 | 国 |
---|
Other private | 560655 | 英国 |
|
---|
引用 | ジャーナル: Sci Adv / 年: 2022 タイトル: Characterization of the membrane interactions of phospholipase C gamma reveals key features of the active enzyme. 著者: Le Huray, K.I.P. / Bunney, T.D. / Pinotsis, N. / Kalli, A.C. / Katan, M. |
---|
履歴 | 登録 | 2022年3月2日 | 登録サイト: PDBE / 処理サイト: PDBE |
---|
改定 1.0 | 2022年7月20日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2024年1月31日 | Group: Data collection / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model |
---|
|
---|