登録情報 | データベース: PDB / ID: 7l3l |
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タイトル | Structure of TRAF5 and TRAF6 RING Hetero dimer |
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要素 | - TNF receptor-associated factor 5
- TNF receptor-associated factor 6TRAF6
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キーワード | TRANSFERASE (転移酵素) / E3 Ligase (ユビキチンリガーゼ) |
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機能・相同性 | 機能・相同性情報
tumor necrosis factor receptor superfamily binding / protein kinase B binding / interleukin-17A-mediated signaling pathway / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / interleukin-17-mediated signaling pathway / interleukin-33-mediated signaling pathway / toll-like receptor 3 signaling pathway / CD40 receptor complex ...tumor necrosis factor receptor superfamily binding / protein kinase B binding / interleukin-17A-mediated signaling pathway / MyD88 dependent cascade initiated on endosome / TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation / MyD88 cascade initiated on plasma membrane / interleukin-17-mediated signaling pathway / interleukin-33-mediated signaling pathway / toll-like receptor 3 signaling pathway / CD40 receptor complex / positive regulation of lipopolysaccharide-mediated signaling pathway / myeloid dendritic cell differentiation / TRIF-dependent toll-like receptor signaling pathway / signal transduction involved in regulation of gene expression / Regulated proteolysis of p75NTR / activation of NF-kappaB-inducing kinase activity / mRNA stabilization / positive regulation of transcription regulatory region DNA binding / thioesterase binding / positive regulation of osteoclast differentiation / tumor necrosis factor receptor binding / regulation of immunoglobulin production / ubiquitin conjugating enzyme binding / regulation of canonical NF-kappaB signal transduction / interleukin-1-mediated signaling pathway / MyD88-dependent toll-like receptor signaling pathway / ubiquitin-ubiquitin ligase activity / toll-like receptor 4 signaling pathway / positive regulation of leukocyte adhesion to vascular endothelial cell / MyD88:MAL(TIRAP) cascade initiated on plasma membrane / TRAF6 mediated IRF7 activation / T-helper 1 type immune response / cytoplasmic pattern recognition receptor signaling pathway / activation of protein kinase activity / cellular response to cytokine stimulus / odontogenesis of dentin-containing tooth / non-canonical NF-kappaB signal transduction / protein K63-linked ubiquitination / Fc-epsilon receptor signaling pathway / antiviral innate immune response / stimulatory C-type lectin receptor signaling pathway / TRAF6 mediated NF-kB activation / autophagosome assembly / positive regulation of type I interferon production / protein autoubiquitination / canonical NF-kappaB signal transduction / positive regulation of JUN kinase activity / bone resorption / lipopolysaccharide-mediated signaling pathway / IRAK2 mediated activation of TAK1 complex / Alpha-protein kinase 1 signaling pathway / IRAK1 recruits IKK complex / IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation / IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation / positive regulation of T cell proliferation / TICAM1,TRAF6-dependent induction of TAK1 complex / tumor necrosis factor-mediated signaling pathway / p75NTR recruits signalling complexes / TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling / positive regulation of interleukin-2 production / extrinsic component of cytoplasmic side of plasma membrane / TRAF6-mediated induction of TAK1 complex within TLR4 complex / NRIF signals cell death from the nucleus / NF-kB is activated and signals survival / positive regulation of interleukin-12 production / 骨化 / lipid droplet / response to interleukin-1 / TICAM1, RIP1-mediated IKK complex recruitment / osteoclast differentiation / IKK complex recruitment mediated by RIP1 / JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 / positive regulation of protein ubiquitination / Regulation of NF-kappa B signaling / neural tube closure / activated TAK1 mediates p38 MAPK activation / positive regulation of JNK cascade / TAK1-dependent IKK and NF-kappa-B activation / RING-type E3 ubiquitin transferase / NOD1/2 Signaling Pathway / cytoplasmic side of plasma membrane / CLEC7A (Dectin-1) signaling / positive regulation of T cell cytokine production / FCERI mediated NF-kB activation / positive regulation of interleukin-6 production / Interleukin-1 signaling / protein polyubiquitination / histone deacetylase binding / ubiquitin-protein transferase activity / SARS-CoV-1 activates/modulates innate immune responses / antigen processing and presentation of exogenous peptide antigen via MHC class II / ubiquitin protein ligase activity / positive regulation of DNA-binding transcription factor activity / Ovarian tumor domain proteases / Downstream TCR signaling / PIP3 activates AKT signaling / positive regulation of NF-kappaB transcription factor activity / 細胞皮質 / T cell receptor signaling pathway / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling類似検索 - 分子機能 TNF receptor-associated factor 5 / TNF receptor-associated factor TRAF / TNF receptor-associated factor 6, zinc finger 2 / TNF receptor-associated factor 6 zinc finger 2 / TNF receptor-associated factor 6 / TNF receptor-associated factor 6, MATH domain / TRAF-type zinc finger / TNF receptor-associated factor TRAF, metazoa / Zinc finger, TRAF-type / Zinc finger TRAF-type profile. ...TNF receptor-associated factor 5 / TNF receptor-associated factor TRAF / TNF receptor-associated factor 6, zinc finger 2 / TNF receptor-associated factor 6 zinc finger 2 / TNF receptor-associated factor 6 / TNF receptor-associated factor 6, MATH domain / TRAF-type zinc finger / TNF receptor-associated factor TRAF, metazoa / Zinc finger, TRAF-type / Zinc finger TRAF-type profile. / : / TRAF/meprin, MATH domain / Zinc finger, C3HC4 type (RING finger) / MATH/TRAF domain / MATH/TRAF domain profile. / meprin and TRAF homology / TRAF-like / Zinc finger, C3HC4 RING-type / Zinc finger, C3HC4 type (RING finger) / Zinc finger, RING-type, conserved site / Zinc finger RING-type signature. / 薬指 / Zinc finger RING-type profile. / Zinc finger, RING-type / Zinc finger, RING/FYVE/PHD-type類似検索 - ドメイン・相同性 TNF receptor-associated factor 5 / TNF receptor-associated factor 6類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.8 Å |
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データ登録者 | Das, A. / Middleton, A.J. / Padala, P. / Day, C.L. |
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資金援助 | ニュージーランド, 1件 組織 | 認可番号 | 国 |
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Health Research Council (HRC) | | ニュージーランド |
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引用 | ジャーナル: J.Mol.Biol. / 年: 2021 タイトル: The structure and ubiquitin binding properties of TRAF RING heterodimers. 著者: Das, A. / Middleton, A.J. / Padala, P. / Ledgerwood, E.C. / Mace, P.D. / Day, C.L. |
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履歴 | 登録 | 2020年12月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2021年2月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2023年10月18日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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