登録情報 | データベース: PDB / ID: 6mba |
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タイトル | Crystal Structure of Human Nav1.4 CTerminal Domain in Complex with apo Calmodulin |
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要素 | - Calmodulin-1カルモジュリン
- Sodium channel protein type 4 subunit alphaナトリウムチャネル
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キーワード | CALMODULIN-BINDING PROTEIN / SCN4A / voltage gated sodium channel (ナトリウムチャネル) / calmodulin (カルモジュリン) / MEMBRANE PROTEIN (膜タンパク質) |
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機能・相同性 | 機能・相同性情報
regulation of skeletal muscle contraction by action potential / voltage-gated sodium channel complex / establishment of protein localization to mitochondrial membrane / type 3 metabotropic glutamate receptor binding / high voltage-gated calcium channel activity / voltage-gated sodium channel activity / establishment of protein localization to membrane / Interaction between L1 and Ankyrins / regulation of synaptic vesicle endocytosis / regulation of synaptic vesicle exocytosis ...regulation of skeletal muscle contraction by action potential / voltage-gated sodium channel complex / establishment of protein localization to mitochondrial membrane / type 3 metabotropic glutamate receptor binding / high voltage-gated calcium channel activity / voltage-gated sodium channel activity / establishment of protein localization to membrane / Interaction between L1 and Ankyrins / regulation of synaptic vesicle endocytosis / regulation of synaptic vesicle exocytosis / organelle localization by membrane tethering / regulation of cardiac muscle cell action potential / mitochondrion-endoplasmic reticulum membrane tethering / autophagosome membrane docking / sodium ion transport / voltage-gated calcium channel complex / nitric-oxide synthase binding / Phase 0 - rapid depolarisation / protein phosphatase activator activity / calcium ion import across plasma membrane / calcium channel regulator activity / adenylate cyclase binding / catalytic complex / sodium ion transmembrane transport / detection of calcium ion / negative regulation of ryanodine-sensitive calcium-release channel activity / cellular response to interferon-beta / regulation of cardiac muscle contraction / calcium channel inhibitor activity / voltage-gated potassium channel complex / phosphatidylinositol 3-kinase binding / regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum / positive regulation of protein dephosphorylation / titin binding / regulation of ryanodine-sensitive calcium-release channel activity / sperm midpiece / response to amphetamine / calcium channel complex / adenylate cyclase activator activity / regulation of heart rate / protein serine/threonine kinase activator activity / nitric-oxide synthase regulator activity / sarcomere / muscle contraction / regulation of cytokinesis / calcium-mediated signaling / spindle microtubule / positive regulation of receptor signaling pathway via JAK-STAT / 紡錘体 / cellular response to type II interferon / response to calcium ion / calcium-dependent protein binding / G2/M transition of mitotic cell cycle / 髄鞘 / 成長円錐 / transmembrane transporter binding / protein domain specific binding / 中心体 / calcium ion binding / protein kinase binding / protein-containing complex / ミトコンドリア / 核質 / 細胞膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 Voltage gated sodium channel, alpha-4 subunit, mammalian / Voltage-gated sodium channel alpha subunit, inactivation gate / Sodium ion transport-associated / Sodium ion transport-associated / Voltage gated sodium channel, alpha subunit / Voltage-gated cation channel calcium and sodium / IQ motif profile. / IQ motif, EF-hand binding site / Voltage-dependent channel domain superfamily / EF-hand domain pair ...Voltage gated sodium channel, alpha-4 subunit, mammalian / Voltage-gated sodium channel alpha subunit, inactivation gate / Sodium ion transport-associated / Sodium ion transport-associated / Voltage gated sodium channel, alpha subunit / Voltage-gated cation channel calcium and sodium / IQ motif profile. / IQ motif, EF-hand binding site / Voltage-dependent channel domain superfamily / EF-hand domain pair / EF-hand, calcium binding motif / EF-Hand 1, calcium-binding site / EF-hand calcium-binding domain. / EF-hand calcium-binding domain profile. / Ion transport domain / Ion transport protein / EF-hand domain / EF-hand domain pair類似検索 - ドメイン・相同性 炭酸塩 / Calmodulin-1 / Sodium channel protein type 4 subunit alpha類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.799 Å |
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データ登録者 | Yoder, J. / Gabelli, S.B. / Amzel, L.M. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI) | 5R01HL128743 | 米国 |
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引用 | ジャーナル: Nat Commun / 年: 2019 タイトル: Ca2+-dependent regulation of sodium channels NaV1.4 and NaV1.5 is controlled by the post-IQ motif. 著者: Yoder, J.B. / Ben-Johny, M. / Farinelli, F. / Srinivasan, L. / Shoemaker, S.R. / Tomaselli, G.F. / Gabelli, S.B. / Amzel, L.M. |
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履歴 | 登録 | 2018年8月29日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年4月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年4月17日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.page_first / _citation.page_last ..._citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name |
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改定 1.2 | 2019年12月4日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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改定 1.3 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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