登録情報 | データベース: PDB / ID: 6ffy |
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タイトル | Structure of the mouse SorCS2-NGF complex |
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要素 | - Beta-nerve growth factor
- VPS10 domain-containing receptor SorCS2
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キーワード | APOPTOSIS (アポトーシス) / SorCS2 / proNGF / p75NTR / VPS10 / Sortilin / neuroplasticity |
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機能・相同性 | 機能・相同性情報
TRKA activation by NGF / NFG and proNGF binds to p75NTR / NADE modulates death signalling / NGF processing / Axonal growth stimulation / Frs2-mediated activation / negative regulation of type B pancreatic cell apoptotic process / positive regulation of neurotrophin TRK receptor signaling pathway / PI3K/AKT activation / ARMS-mediated activation ...TRKA activation by NGF / NFG and proNGF binds to p75NTR / NADE modulates death signalling / NGF processing / Axonal growth stimulation / Frs2-mediated activation / negative regulation of type B pancreatic cell apoptotic process / positive regulation of neurotrophin TRK receptor signaling pathway / PI3K/AKT activation / ARMS-mediated activation / nerve growth factor receptor binding / NRIF signals cell death from the nucleus / p75NTR recruits signalling complexes / Retrograde neurotrophin signalling / NF-kB is activated and signals survival / positive regulation of neuron maturation / death receptor agonist activity / metalloendopeptidase inhibitor activity / nerve growth factor signaling pathway / regulation of neurotransmitter secretion / nerve development / positive regulation of collateral sprouting / peripheral nervous system development / regulation of release of sequestered calcium ion into cytosol / axon extension / positive regulation of Ras protein signal transduction / long-term synaptic depression / regulation of neuron differentiation / transmembrane receptor protein tyrosine kinase activator activity / positive regulation of stem cell proliferation / extrinsic apoptotic signaling pathway via death domain receptors / positive regulation of axon extension / cysteine-type endopeptidase activator activity involved in apoptotic process / positive regulation of DNA binding / sensory perception of pain / positive regulation of protein autophosphorylation / extrinsic apoptotic signaling pathway in absence of ligand / positive regulation of neuron differentiation / adult locomotory behavior / neuron projection morphogenesis / positive regulation of protein ubiquitination / endosome lumen / postsynaptic density membrane / intracellular protein transport / growth factor activity / modulation of chemical synaptic transmission / 記憶 / positive regulation of neuron projection development / 概日リズム / recycling endosome membrane / neuron projection development / cell surface receptor protein tyrosine kinase signaling pathway / シナプス小胞 / positive regulation of peptidyl-serine phosphorylation / perikaryon / early endosome membrane / positive regulation of cell growth / neuron apoptotic process / negative regulation of neuron apoptotic process / 樹状突起スパイン / postsynaptic density / positive regulation of ERK1 and ERK2 cascade / positive regulation of protein phosphorylation / 神経繊維 / 小胞体 / intracellular membrane-bounded organelle / 樹状突起 / lipid binding / positive regulation of cell population proliferation / positive regulation of gene expression / extracellular space / extracellular region / 生体膜 / 細胞膜 / 細胞質基質類似検索 - 分子機能 Nerve growth factor, beta subunit, mammalian / Nerve growth factor, beta subunit / Nerve growth factor family profile. / Nerve growth factor-related / Nerve growth factor conserved site / Nerve growth factor-like / Nerve growth factor family / Nerve growth factor family signature. / Nerve growth factor (NGF or beta-NGF) / VPS10 ...Nerve growth factor, beta subunit, mammalian / Nerve growth factor, beta subunit / Nerve growth factor family profile. / Nerve growth factor-related / Nerve growth factor conserved site / Nerve growth factor-like / Nerve growth factor family / Nerve growth factor family signature. / Nerve growth factor (NGF or beta-NGF) / VPS10 / Sortilin, C-terminal / Sortilin, N-terminal / Sortilin, neurotensin receptor 3, C-terminal / Sortilin, neurotensin receptor 3, / VPS10 / PKD domain / Polycystic kidney disease (PKD) domain profile. / PKD domain / PKD domain superfamily / Cystine Knot Cytokines, subunit B / Cystine-knot cytokines / Cystine-knot cytokine / リボン / WD40/YVTN repeat-like-containing domain superfamily / Immunoglobulin-like fold / Mainly Beta類似検索 - ドメイン・相同性 Beta-nerve growth factor / VPS10 domain-containing receptor SorCS2類似検索 - 構成要素 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.9 Å |
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データ登録者 | Leloup, N.O.L. / Janssen, B.J.C. |
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資金援助 | オランダ, 1件 組織 | 認可番号 | 国 |
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ManiFold Marie Curie FP7 | 317371 | オランダ |
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引用 | ジャーナル: Nat Commun / 年: 2018 タイトル: Structural insights into SorCS2-Nerve Growth Factor complex formation. 著者: Leloup, N. / Chataigner, L.M.P. / Janssen, B.J.C. |
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履歴 | 登録 | 2018年1月9日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2018年8月1日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年8月15日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name |
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改定 2.0 | 2020年7月29日 | Group: Advisory / Atomic model ...Advisory / Atomic model / Data collection / Derived calculations / Structure summary カテゴリ: atom_site / chem_comp ...atom_site / chem_comp / entity / pdbx_branch_scheme / pdbx_chem_comp_identifier / pdbx_entity_branch / pdbx_entity_branch_descriptor / pdbx_entity_branch_link / pdbx_entity_branch_list / pdbx_entity_nonpoly / pdbx_nonpoly_scheme / pdbx_struct_assembly_gen / pdbx_validate_close_contact / struct_asym / struct_conn / struct_site / struct_site_gen Item: _atom_site.auth_asym_id / _atom_site.auth_seq_id ..._atom_site.auth_asym_id / _atom_site.auth_seq_id / _atom_site.label_asym_id / _atom_site.label_entity_id / _chem_comp.name / _chem_comp.type / _entity.formula_weight / _entity.pdbx_description / _entity.pdbx_number_of_molecules / _entity.type / _pdbx_struct_assembly_gen.asym_id_list / _pdbx_validate_close_contact.auth_asym_id_2 / _pdbx_validate_close_contact.auth_seq_id_2 / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 2.1 | 2024年1月17日 | Group: Data collection / Database references ...Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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