登録情報 | データベース: PDB / ID: 5c46 |
---|
タイトル | Crystal structure of an engineered construct of phosphatidylinositol 4 kinase III beta in complex with GTP gamma S loaded Rab11 |
---|
要素 | - Phosphatidylinositol 4-kinase beta
- Ras-related protein Rab-11A
|
---|
キーワード | Transferase/Signaling Protein / Protein-protein complex / lipid kinase (キナーゼ) / GTPase complex (GTPアーゼ) / Transferase-Signaling Protein complex |
---|
機能・相同性 | 機能・相同性情報
regulation of early endosome to recycling endosome transport / regulation of protein localization to centrosome / regulation of multivesicular body size / 1-phosphatidylinositol 4-kinase / 1-phosphatidylinositol 4-kinase activity / regulation of endocytic recycling / postsynaptic recycling endosome / establishment of protein localization to organelle / plasma membrane to endosome transport / establishment of vesicle localization ...regulation of early endosome to recycling endosome transport / regulation of protein localization to centrosome / regulation of multivesicular body size / 1-phosphatidylinositol 4-kinase / 1-phosphatidylinositol 4-kinase activity / regulation of endocytic recycling / postsynaptic recycling endosome / establishment of protein localization to organelle / plasma membrane to endosome transport / establishment of vesicle localization / regulation of cilium assembly / exosomal secretion / amyloid-beta clearance by transcytosis / rough endoplasmic reticulum membrane / melanosome transport / astral microtubule organization / VxPx cargo-targeting to cilium / neurotransmitter receptor transport, endosome to postsynaptic membrane / Synthesis of PIPs at the Golgi membrane / regulation of vesicle-mediated transport / RAB geranylgeranylation / myosin V binding / protein localization to cilium / multivesicular body assembly / phosphatidylinositol biosynthetic process / dynein light intermediate chain binding / establishment of protein localization to membrane / protein localization to cell surface / TBC/RABGAPs / syntaxin binding / mitotic metaphase chromosome alignment / lysosome organization / positive regulation of epithelial cell migration / エキソサイトーシス / inner ear development / phosphatidylinositol-mediated signaling / 分裂溝 / phosphatidylinositol phosphate biosynthetic process / mitotic spindle assembly / centriolar satellite / phagocytic vesicle / vesicle-mediated transport / 小胞 / positive regulation of G2/M transition of mitotic cell cycle / Anchoring of the basal body to the plasma membrane / receptor-mediated endocytosis / 中心小体 / エンドソーム / 低分子量GTPアーゼ / G protein activity / trans-Golgi network membrane / 14-3-3 protein binding / regulation of cytokinesis / Translocation of SLC2A4 (GLUT4) to the plasma membrane / protein localization to plasma membrane / ゴルジ体 / cytoplasmic vesicle membrane / recycling endosome / Vasopressin regulates renal water homeostasis via Aquaporins / 紡錘体 / recycling endosome membrane / neuron projection development / endocytic vesicle membrane / cytoplasmic vesicle / microtubule binding / vesicle / mitochondrial outer membrane / エンドソーム / リン酸化 / ゴルジ体 / intracellular membrane-bounded organelle / GTPase activity / 中心体 / glutamatergic synapse / GTP binding / perinuclear region of cytoplasm / ゴルジ体 / シグナル伝達 / protein-containing complex / extracellular exosome / ATP binding / 生体膜 / 細胞質基質 / 細胞質類似検索 - 分子機能 : / PI4KB/PIK1, accessory (PIK) domain / small GTPase Rab1 family profile. / Phosphoinositide 3-kinase, accessory (PIK) domain / Phosphatidylinositol kinase / PIK helical domain profile. / Phosphatidylinositol 3- and 4-kinases signature 1. / Phosphatidylinositol 3/4-kinase, conserved site / Phosphatidylinositol 3- and 4-kinases signature 2. / Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily ...: / PI4KB/PIK1, accessory (PIK) domain / small GTPase Rab1 family profile. / Phosphoinositide 3-kinase, accessory (PIK) domain / Phosphatidylinositol kinase / PIK helical domain profile. / Phosphatidylinositol 3- and 4-kinases signature 1. / Phosphatidylinositol 3/4-kinase, conserved site / Phosphatidylinositol 3- and 4-kinases signature 2. / Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily / Phosphoinositide 3-kinase, catalytic domain / Phosphatidylinositol 3- and 4-kinase / Phosphatidylinositol 3- and 4-kinases catalytic domain profile. / Phosphatidylinositol 3-/4-kinase, catalytic domain / Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / 低分子量GTPアーゼ / 低分子量GTPアーゼ / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / Protein kinase-like domain superfamily / P-loop containing nucleoside triphosphate hydrolase / ロスマンフォールド / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE / Ras-related protein Rab-11A / Phosphatidylinositol 4-kinase beta類似検索 - 構成要素 |
---|
生物種 | Homo sapiens (ヒト) |
---|
手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.65 Å |
---|
データ登録者 | Burke, J.E. / Fowler, M.L. |
---|
資金援助 | カナダ, 1件 組織 | 認可番号 | 国 |
---|
Natural Sciences and Engineering Research Council (NSERC, Canada) | NSERC-2014-05218 | カナダ |
|
---|
引用 | ジャーナル: Protein Sci. / 年: 2016 タイトル: Using hydrogen deuterium exchange mass spectrometry to engineer optimized constructs for crystallization of protein complexes: Case study of PI4KIII beta with Rab11. 著者: Fowler, M.L. / McPhail, J.A. / Jenkins, M.L. / Masson, G.R. / Rutaganira, F.U. / Shokat, K.M. / Williams, R.L. / Burke, J.E. |
---|
履歴 | 登録 | 2015年6月17日 | 登録サイト: RCSB / 処理サイト: RCSB |
---|
改定 1.0 | 2016年1月20日 | Provider: repository / タイプ: Initial release |
---|
改定 1.1 | 2016年4月6日 | Group: Database references |
---|
改定 1.2 | 2017年9月20日 | Group: Author supporting evidence / Database references / Derived calculations カテゴリ: citation / pdbx_audit_support / pdbx_struct_oper_list Item: _citation.journal_id_CSD / _pdbx_audit_support.funding_organization / _pdbx_struct_oper_list.symmetry_operation |
---|
改定 1.3 | 2020年1月8日 | Group: Author supporting evidence / カテゴリ: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
---|
改定 1.4 | 2023年9月27日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|