登録情報 データベース : PDB / ID : 4qj5 構造の表示 ダウンロードとリンクタイトル Structure of a fragment of human phospholipase C-beta3 delta472-581, bound to IP3 and in complex with Galphaq 要素1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 Guanine nucleotide-binding protein G(q) subunit alpha 詳細キーワード SIGNALING PROTEIN/HYDROLASE / GTP-BINDING PROTEIN ALPHA SUBUNITS (Gタンパク質) / PHOSPHOLIPASE C BETA / PH DOMAIN / EF HAND (EFハンド) / C2 DOMAIN (C2ドメイン) / TIM BARREL DOMAIN (TIMバレル) / GTP HYDROLYSIS / G-PROTEIN SIGNALING (Gタンパク質) / LIPASE (リパーゼ) / CALCIUM BINDING (カルシウム) / GTP BINDING / PHOSPHOLIPIDS (リン脂質) / membrane (生体膜) / SIGNALING PROTEIN-HYDROLASE complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion / Acetylcholine regulates insulin secretion / PLC beta mediated events / forebrain neuron development / regulation of melanocyte differentiation / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / Thromboxane signalling through TP receptor / Thrombin signalling through proteinase activated receptors (PARs) / G-protein activation / phosphoinositide phospholipase C ... Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion / Acetylcholine regulates insulin secretion / PLC beta mediated events / forebrain neuron development / regulation of melanocyte differentiation / Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding / Thromboxane signalling through TP receptor / Thrombin signalling through proteinase activated receptors (PARs) / G-protein activation / phosphoinositide phospholipase C / Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion / Acetylcholine regulates insulin secretion / G alpha (q) signalling events / endothelin receptor signaling pathway / ion channel modulating, G protein-coupled receptor signaling pathway / phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway / developmental pigmentation / phosphatidylinositol metabolic process / PLC beta mediated events / phospholipase C-activating dopamine receptor signaling pathway / cranial skeletal system development / regulation of platelet activation / ADP signalling through P2Y purinoceptor 1 / regulation of systemic arterial blood pressure / maternal behavior / phosphatidylinositol phospholipase C activity / phospholipase C activity / glutamate receptor signaling pathway / phosphatidylinositol-mediated signaling / regulation of canonical Wnt signaling pathway / alkylglycerophosphoethanolamine phosphodiesterase activity / postsynaptic cytosol / 活動電位 / neuron remodeling / embryonic digit morphogenesis / Synthesis of IP3 and IP4 in the cytosol / ligand-gated ion channel signaling pathway / negative regulation of potassium ion transport / enzyme regulator activity / lipid catabolic process / release of sequestered calcium ion into cytosol / GTPase activator activity / post-embryonic development / G protein activity / skeletal system development / molecular function activator activity / G protein-coupled receptor binding / カベオラ / positive regulation of smooth muscle cell proliferation / G-protein beta/gamma-subunit complex binding / G beta:gamma signalling through PLC beta / Presynaptic function of Kainate receptors / adenylate cyclase-activating G protein-coupled receptor signaling pathway / positive regulation of insulin secretion / 血圧 / heterotrimeric G-protein complex / cell body / Ca2+ pathway / phospholipase C-activating G protein-coupled receptor signaling pathway / heart development / G alpha (q) signalling events / 核膜 / protein stabilization / molecular adaptor activity / calmodulin binding / cadherin binding / G protein-coupled receptor signaling pathway / GTPase activity / 樹状突起 / シナプス / calcium ion binding / protein-containing complex binding / GTP binding / negative regulation of apoptotic process / ゴルジ体 / protein-containing complex / 生体膜 / metal ion binding / 細胞核 / 細胞膜 / 細胞質基質 類似検索 - 分子機能 PH-domain like - #240 / Phospholipase C-beta, C-terminal domain / PLC-beta C terminal / PLC-beta, PH domain / Phospholipase C-beta, C-terminal domain superfamily / PH domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta / Phosphoinositide-specific phospholipase C, EF-hand-like domain / Phosphoinositide-specific phospholipase C, efhand-like / G-protein alpha subunit, group Q ... PH-domain like - #240 / Phospholipase C-beta, C-terminal domain / PLC-beta C terminal / PLC-beta, PH domain / Phospholipase C-beta, C-terminal domain superfamily / PH domain / Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta / Phosphoinositide-specific phospholipase C, EF-hand-like domain / Phosphoinositide-specific phospholipase C, efhand-like / G-protein alpha subunit, group Q / Phosphoinositide phospholipase C family / Phospholipase C, phosphatidylinositol-specific, Y domain / Phosphatidylinositol-specific phospholipase C, Y domain / Phosphatidylinositol-specific phospholipase Y-box domain profile. / Phospholipase C, catalytic domain (part); domain Y / Phosphatidylinositol (PI) phosphodiesterase / Phosphatidylinositol-specific phospholipase X-box domain profile. / Phosphatidylinositol-specific phospholipase C, X domain / Phosphatidylinositol-specific phospholipase C, X domain / Phospholipase C, catalytic domain (part); domain X / GI Alpha 1, domain 2-like / GI Alpha 1, domain 2-like / PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily / C2ドメイン / C2ドメイン / Protein kinase C conserved region 2 (CalB) / C2ドメイン / C2 domain profile. / PH-domain like / EFハンド / Recoverin; domain 1 / C2 domain superfamily / G-alpha domain profile. / Guanine nucleotide binding protein (G-protein), alpha subunit / G protein alpha subunit, helical insertion / G-protein alpha subunit / G protein alpha subunit / EF-hand domain pair / P-loop containing nucleotide triphosphate hydrolases / Roll / TIMバレル / Alpha-Beta Barrel / Immunoglobulin-like / サンドイッチ / P-loop containing nucleoside triphosphate hydrolase / ロスマンフォールド / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Beta / Mainly Alpha / Alpha Beta 類似検索 - ドメイン・相同性 TETRAFLUOROALUMINATE ION / GUANOSINE-5'-DIPHOSPHATE / D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE / Guanine nucleotide-binding protein G(q) subunit alpha / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 類似検索 - 構成要素生物種 Mus musculus (ハツカネズミ)Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.41 Å 詳細データ登録者 Lyon, A.M. / Tesmer, J.J.G. 引用ジャーナル : Structure / 年 : 2014タイトル : Molecular mechanisms of phospholipase C beta 3 autoinhibition.著者 : Lyon, A.M. / Begley, J.A. / Manett, T.D. / Tesmer, J.J. 履歴 登録 2014年6月3日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2014年10月22日 Provider : repository / タイプ : Initial release改定 1.1 2014年12月24日 Group : Database references改定 1.2 2015年2月11日 Group : Database references改定 1.3 2017年8月2日 Group : Data collection / Refinement description / Source and taxonomyカテゴリ : diffrn_detector / entity_src_gen / software / Item : _diffrn_detector.detector改定 1.4 2023年9月20日 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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