登録情報 データベース : PDB / ID : 3n57 構造の表示 ダウンロードとリンクタイトル Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP) 要素Atrial natriuretic factor Insulin-degrading enzyme インスリン分解酵素 詳細キーワード HYDROLASE/HORMONE / INSULYSIN (インスリシン) / INSULINASE / A-BETA DEGRADING ENZYME / CRYPTIDASE / HYDROLASE (加水分解酵素) / HORMONE (ホルモン) / DISEASE MUTATION / DIABETES MELLITUS (糖尿病) / INSULIN (インスリン) / CARDIAC (心臓) / SECRETED (分泌) / PROTEASE (プロテアーゼ) / DISULFIDE BOND (ジスルフィド) / METALLOPROTEASE (金属プロテアーゼ) / HUMAN INSULIN-DEGRADNG ENZYME / METAL-BINDING / NATRIURETIC PEPTIDE / NATRIURETIC FACTOR / CARDIOVASCULAR REGULATION / HYDROLASE-HORMONE complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of delayed rectifier potassium channel activity / receptor guanylyl cyclase signaling pathway / neuropeptide receptor binding / regulation of high voltage-gated calcium channel activity / positive regulation of potassium ion export across plasma membrane / cGMP biosynthetic process / regulation of atrial cardiac muscle cell membrane repolarization / インスリシン / Physiological factors / ubiquitin recycling ... positive regulation of delayed rectifier potassium channel activity / receptor guanylyl cyclase signaling pathway / neuropeptide receptor binding / regulation of high voltage-gated calcium channel activity / positive regulation of potassium ion export across plasma membrane / cGMP biosynthetic process / regulation of atrial cardiac muscle cell membrane repolarization / インスリシン / Physiological factors / ubiquitin recycling / insulin catabolic process / insulin metabolic process / cardiac conduction system development / YAP1- and WWTR1 (TAZ)-stimulated gene expression / sodium ion export across plasma membrane / amyloid-beta clearance by cellular catabolic process / hormone catabolic process / negative regulation of JUN kinase activity / bradykinin catabolic process / neuropeptide hormone activity / negative regulation of systemic arterial blood pressure / cardiac muscle hypertrophy in response to stress / hormone receptor binding / aortic valve morphogenesis / ubiquitin-modified protein reader activity / regulation of calcium ion transmembrane transport via high voltage-gated calcium channel / insulin binding / regulation of aerobic respiration / positive regulation of heart rate / peptide catabolic process / cGMP-mediated signaling / amyloid-beta clearance / peroxisomal matrix / neuropeptide signaling pathway / amyloid-beta metabolic process / positive regulation of cardiac muscle contraction / Insulin receptor recycling / response to muscle stretch / proteolysis involved in protein catabolic process / cell projection / female pregnancy / Peroxisomal protein import / peptide binding / protein catabolic process / hormone activity / metalloendopeptidase activity / antigen processing and presentation of endogenous peptide antigen via MHC class I / 血圧 / ペルオキシソーム / vasodilation / positive regulation of protein catabolic process / フォールディング / virus receptor activity / insulin receptor signaling pathway / positive regulation of protein binding / perikaryon / basolateral plasma membrane / collagen-containing extracellular matrix / endopeptidase activity / Ub-specific processing proteases / Amyloid fiber formation / external side of plasma membrane / signaling receptor binding / 細胞膜 / protein homodimerization activity / protein-containing complex / ミトコンドリア / タンパク質分解 / extracellular space / extracellular exosome / zinc ion binding / extracellular region / ATP binding / identical protein binding / 細胞核 / 細胞質基質 / 細胞質 類似検索 - 分子機能 Natriuretic peptide, atrial type / Natriuretic peptide, conserved site / 心房性ナトリウム利尿ペプチド / Natriuretic peptides signature. / Natriuretic peptide / Natriuretic peptide / Peptidase M16, middle/third domain / Middle or third domain of peptidase_M16 / Cytochrome Bc1 Complex; Chain A, domain 1 / Metalloenzyme, LuxS/M16 peptidase-like ... Natriuretic peptide, atrial type / Natriuretic peptide, conserved site / 心房性ナトリウム利尿ペプチド / Natriuretic peptides signature. / Natriuretic peptide / Natriuretic peptide / Peptidase M16, middle/third domain / Middle or third domain of peptidase_M16 / Cytochrome Bc1 Complex; Chain A, domain 1 / Metalloenzyme, LuxS/M16 peptidase-like / Peptidase M16, zinc-binding site / Insulinase family, zinc-binding region signature. / Peptidase M16, C-terminal / Peptidase M16 inactive domain / Peptidase M16, N-terminal / Insulinase (Peptidase family M16) / Metalloenzyme, LuxS/M16 peptidase-like / 2-Layer Sandwich / Alpha Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.03 Å 詳細データ登録者 Funke, T. / Guo, Q. / Tang, W.-J. 引用ジャーナル : To be Published タイトル : Crystal Structure of human Insulin-degrading enzyme (IDE) in complex with human atrial natriuretic peptide (ANP)著者 : Ralat, L.A. / Funke, T. / Ren, M. / Guo, Q. / Dickey, D.M. / Potter, L.R. / Tang, W.-J. 履歴 登録 2010年5月24日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2010年11月17日 Provider : repository / タイプ : Initial release改定 1.1 2011年7月13日 Group : Version format compliance改定 1.2 2017年11月8日 Group : Database references / Refinement description / Source and taxonomyカテゴリ : citation_author / entity_src_gen / softwareItem : _citation_author.name / _entity_src_gen.pdbx_host_org_ncbi_taxonomy_id / _entity_src_gen.pdbx_host_org_scientific_name改定 1.3 2024年2月21日 Group : Data collection / Database references / Derived calculationsカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_struct_conn_angle / struct_conn / struct_ref_seq_dif / struct_site Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_asym_id / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr2_auth_asym_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_asym_id / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.value / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_ref_seq_dif.details / _struct_site.pdbx_auth_asym_id / _struct_site.pdbx_auth_comp_id / _struct_site.pdbx_auth_seq_id
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